A5101648882- Immune Cell Function and Interaction
- Gastrointestinal motility and disorders
- Acupuncture Treatment Research Studies
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Gut microbiota and health
- Plant Pathogens and Fungal Diseases
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Studies
- Geophysical and Geoelectrical Methods
- Melanoma and MAPK Pathways
- Lipid metabolism and biosynthesis
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral gastroenteritis research and epidemiology
- Infant Health and Development
- Tea Polyphenols and Effects
- Prenatal Screening and Diagnostics
- Virus-based gene therapy research
- Heart Rate Variability and Autonomic Control
- Plant-Microbe Interactions and Immunity
- Neurogenetic and Muscular Disorders Research
- Crystallization and Solubility Studies
- Fetal and Pediatric Neurological Disorders
Sichuan University
2022-2025
West China Hospital of Sichuan University
2022-2025
Wenzhou Medical University
2025
Yantai University
2024
Soochow University
2017-2024
Southern Medical University
2024
Anhui University of Traditional Chinese Medicine
2020-2024
Zhejiang Normal University
2024
Henan Provincial People's Hospital
2019-2024
Zhengzhou University
2023-2024
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T through an 'inside out' signalling process whereby structurally diverse phosphoantigen (pAg) molecules sensed by the intracellular domain of butyrophilin BTN3A11-4. Here we show how-in humans alpaca-multiple pAgs function as 'molecular glues' promote heteromeric association between domains BTN3A1 similar BTN2A1. X-ray crystallography studies visualized that engagement with forms a composite interface for direct...
Entrepreneurial activity measures a country's economic vitality. Studies have examined the psychological cognitive conditions that influence women's entrepreneurial by considering effects of individual in isolation while ignoring their interdependence. Based on necessary condition analysis and fuzzy-set qualitative comparative analysis, this study utilized data from 2021 Global Entrepreneurship Monitor report for 42 countries explored complex causal mechanisms driving activity. We observed...
In the present study, biosynthesis of silver nanoparticles (AgNPs) and their antibacterial activity against gram-positive gram-negative bacteria were investigated. Glycyrrhizin (GL) was used as a reducing agent stabilizer to rapidly prepare AgNPs. The distinctive absorption peak at 419 nm confirmed formation GL-reduced TEM particle size analysis shows that prepared AgNPs mostly circular with good dispersion relatively uniform 35 on average. Fourier transform infrared spectroscopy performed...
Rising studies have consistently reported gut bacteriome alterations in schizophrenia (SCZ). However, little is known about the role of virome on shaping SCZ. Here in, we sequenced fecal virome, bacteriome, and host peripheral metabolome 49 SCZ patients health controls (HCs). We compared bacterial community composition specific abundant bacteria HCs. Specific viruses metabolites co-occurring with differential were identified using Multiple Co-inertia Analysis (MCIA). Additionally, construct...
This study explores the relationship between digital entrepreneurial ecosystem and female activity in 45 countries using Fuzzy Set Qualitative Comparative Analysis (fsQCA). It highlights importance of entrepreneurship for economic social development examines how Digital Entrepreneurial Ecosystem elements collectively impact activity. Methodologically, it combines Necessary Condition (NCA) fsQCA, data from Global Entrepreneurship Monitor (GEM) 2022 2018 Economy Development Index Report. The...
Gastrointestinal dysmotility is a common cause of functional dyspepsia. As two kinds polysaccharides derived from brown algae, fucoidan and laminarin possess many physiological properties; however, their relative abilities in regulating gastrointestinal motility have not been illustrated yet. In this study, we aimed to investigate the regulatory effect on dyspepsia mice induced by loperamide. Mice with were treated (100 200 mg per kg bw) (50 100 bw). result, reversed dysfunction mainly...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a typical immunosuppressive causing large economic impact on the swine industry. The structural protein GP5 of PRRSV plays pivotal role in its pathogenicity immune evasion. Virus–host interactions play crucial part viral replication escape. Therefore, understanding between host proteins are significant for porcine (PRRS) control. However, interaction network primary alveolar macrophages (PAMs) has not been reported. In this...
The mammalian Ste20-like kinase 1 (Mst-1) is a serine-threonine and component of the Hippo tumor suppressor pathway, which reacts to pathologically relevant stress regulates cell death. However, little known about its role in spinal cord injury. Here, we found that p-Mst-1, activated form Mst-1, was induced post-traumatic motor neurons. In vivo evidence demonstrated Mst-1 deficiency promoted neuron survival, Basso mouse scale scores, synapse survival. Moreover, autophagosome formation...
N6-methyladenosine (m6A) was the most abundant modification of mRNA and lncRNA in mammalian cells played an important role many biological processes. However, whether m6A associated with recurrent spontaneous abortion (RSA) its roles were still unclear. Methods: Methylated RNA immunoprecipitation sequencing (MeRIP-Seq) used to study global pattern RSAs controls. (RNA-Seq) level two groups. Real-time quantitative PCR (RT-qPCR) verify METTL3 ZBTB4. MeRIP-qPCR conducted test ZBTB4 In order...
Introduction: Chronic stress has been shown to cause liver damage in addition psychological depression. Besides, drug-induced injury is frequently caused by antidepressants. Shuxie-1 decoction (SX-1) a formula of traditional Chinese medicine commonly used nourishing blood, and relieving However, the underlying molecular mechanism remains unclear. Therefore, this study was designed explore effects mechanisms SX-1 treating chronic stress-induced depression as well injury. Methods:...
Our study suggests that this dorsomedial hypothalamus (DMH)-raphe pallidus (RP)-cardiac sympathetic pathway involves in the improvement of cardiac dysfunction associated with stress by administrating electroacupuncture at PC6, thus providing beneficial information for development therapeutic strategies to prevent stress-induced cardiovascular diseases, and insight into neural basis PC6 intervention dysfunction.
Introduction: Sleep disorders are common clinical psychosomatic that can co-exist with a variety of conditions. In humans and animal models, sleep deprivation (SD) is closely related gastrointestinal diseases. Shu-Xie Decoction (SX) traditional Chinese medicine (TCM) anti-nociceptive, anti-inflammatory, antidepressant properties. SX effective in the clinic for treating patients abnormal and/or disorders, but underlying mechanisms not known. This study investigated by which alleviates...
Colletotrichum gloeosporioides is one of the most serious diseases that causes damage to mangoes. Laccase, a copper-containing polyphenol oxidase, has been reported in many species with different functions and activities, fungal laccase could be closely related mycelial growth, melanin appressorium formation, pathogenicity, so on. Therefore, what relationship between pathogenicity? Do genes have functions? In this experiment, knockout mutant complementary strain Cglac13 were obtained through...
Curcumin has been proven to be an effective strategy for reducing inflammatory responses. However, low bioavailability and instability at the physiological pH have limited its anti-inflammatory activity in ulcerative colitis patients. In present study, a complex of curcumin konjac glucomannan (KGM) effectively inhibited intestinal inflammation this effect was associated with KGM degradation degrees. Results demonstrated that treatment markedly mitigated symptoms decreased cytokines levels,...
Summary Tongue diagnosis is an important clinical examination in Traditional Chinese Medicine. As the first step of diagnosis, accuracy tongue image segmentation directly affects subsequent diagnosis. Recently, deep learning‐based methods have been applied for and achieve promising results. However, these usually work well on one dataset degenerate significantly different distributed datasets. To deal with this issue, we propose a framework named Iterative cross‐domain study. First, train...
Aim: Genome-wide association studies (GWAS) analyses have revealed genetic evidence of bipolar disorder (BD), but little is known about the structure BD subtypes. We aimed to investigate overlap and distinction type I (BD I) & II II) by conducting integrative post-GWAS analyses. Methods: utilized single nucleotide polymorphism (SNP)-level approaches uncover correlated distinct loci. Transcriptome-wide (TWAS) were then approached pinpoint functional genes expressed in specific brain tissues...
Erchen decoction (ECD) is a common treatment prescribed in traditional Chinese medicine (TCM) clinics, which has remarkable efficacy the of obesity, fatty liver, hyperlipidemia, diabetes, and other diseases caused by phlegm. In this study, we investigated effect that ECD had on lipid metabolism induced high-fat diet C57BL/6 mice. Body weight, body length, abdominal circumference were detected. Blood content was measured via biochemical assay kit. The gene protein expression PPARγ LPL...
Due to the rapid mutation of porcine epidemic diarrhea virus (PEDV), existing vaccines cannot provide sufficient immune protection for pigs. Therefore, it is urgent design affinity peptides prevention and control this disease. In study, we made use a molecular docking technology virtual screening that specifically recognized PEDV S1 C-terminal domain (CTD) protein first time. Experimentally, affinity, cross-reactivity sensitivity were identified by an enzyme-linked immunosorbent assay...
Background: Banxia Xiexin decoration (BXD), a complex prescription in Traditional Chinese Medicine (TCM), clinically acts as treatment for gastritis and diabetes while its mechanism of remains unknown. Objection: This study aimed to explore the common BXD treating based on network pharmacology molecular docking technology. Methods: The seven herbal components drug targets were collected from Systems Pharmacology Database Analysis Platform (TCMSP) using GeneCards, DisGeNET, Comparative...