A5074119485- Multicomponent Synthesis of Heterocycles
- Microplastics and Plastic Pollution
- biodegradable polymer synthesis and properties
- Synthesis of Organic Compounds
- Carbohydrate Chemistry and Synthesis
- Synthesis of heterocyclic compounds
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of Indole Derivatives
- Catalytic Alkyne Reactions
- Effects and risks of endocrine disrupting chemicals
- HIV/AIDS drug development and treatment
- Organophosphorus compounds synthesis
- Catalytic C–H Functionalization Methods
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Retinoids in leukemia and cellular processes
- Microbial Natural Products and Biosynthesis
- Synthesis and Catalytic Reactions
- Synthesis and Reactivity of Heterocycles
- Monoclonal and Polyclonal Antibodies Research
Hubei University
2020-2023
Center for Life Sciences
2023
Tsinghua University
2023
Jiangsu Ocean University
2013-2015
Henan Normal University
2009-2011
Abstract Poly(butylene adipate-co-terephthalate) (PBAT), a polyester made of terephthalic acid (TPA), 1,4-butanediol, and adipic acid, is extensively utilized in plastic production has accumulated globally as environmental waste. Biodegradation an attractive strategy to manage PBAT, but effective PBAT-degrading enzyme required. Here, we demonstrate that cutinases are highly potent enzymes can completely decompose PBAT films 48 h. We further show the engineered cutinases, by applying double...
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T through an 'inside out' signalling process whereby structurally diverse phosphoantigen (pAg) molecules sensed by the intracellular domain of butyrophilin BTN3A11-4. Here we show how-in humans alpaca-multiple pAgs function as 'molecular glues' promote heteromeric association between domains BTN3A1 similar BTN2A1. X-ray crystallography studies visualized that engagement with forms a composite interface for direct...
A novel, rapid, and efficient synthesis of bicyclic pyrimidine nucleosides benzopyran-4-ones through oxidation homopropargyl alcohols subsequent isomerization, intramolecular addition enol to allenic ketone has been developed. This methodology provides an promising approach the structurally pharmaceutically interesting pyrano[2,3-d]pyrimidine-2,5-dione nucleoside benzopyran-4-one derivatives.
A novel and highly efficient one-pot three-component synthesis of alpha-aminophosphonates under neat condition was developed. By employing this method, hybrid compounds aminophosphonate with pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-formyl-2'-deoxyuridine, aniline dimethyl phosphite. The antiviral antileishmanial activities these also studied but none found be active.
A new, simplified method for the synthesis of dimethyl aryl acylsulfonium salts has been developed. series bromides were prepared by reaction methyl ketones with hydrobromic acid and dimethylsulfoxide (DMSO). This sulfonium salt confirms that bromine production bromination take place in DMSO-HBr oxidation system. What's more, it is also a key intermediate arylglyoxals.
Human Vγ9Vδ2 T cells detect cancerous and pathogen-infected through an "inside-out" mechanism wherein intracellular domains of butyrophilin (BTN) proteins recognize phosphoantigens (pAgs) to prime BTN ectodomains engage with the cell receptor (TCR) activate cells. Here, we present cryo-electron microscopy (cryo-EM) structures, including full-length BTN3A1-BTN3A2-BTN2A1 complex stabilized by pAg HMBPP HMBPP-primed multimer engaged TCR. The confirms that this bridges B30.2 BTN3A1 BTN2A1, while...
GRAPHICAL ABSTRACT
Ginsenoside Rg3 is a bioactive compound from Panax ginseng and exhibits diverse notable biological properties. Glycosylation catalyzed by uridine diphosphate-dependent glycosyltransferase (UGT) the final biosynthetic step of ginsenoside determines its pharmacological activities. In present study, promiscuous UGT Bs-YjiC Bacillus subtilis 168 was expressed in Escherichia coli purified via one-step nickel chelate affinity chromatography. The vitro glycosylation reaction demonstrated Bs-Yjic...
Calycosin-7-O-β-D-glucoside (Cy7G) is one of the principal components Radix astragali. This isoflavonoid glucoside regarded as an indicator to assess quality R. astragali and exhibits diverse pharmacological activities. In this study, uridine diphosphate-dependent glucosyltransferase (UGT) UGT88E18 was isolated from Glycine max expressed in Escherichia coli. Recombinant could selectively effectively glucosylate C7 hydroxyl group calycosin synthesize Cy7G. A one-pot reaction by coupling...
The utilisation of an ionic liquid-[bmim][BF 4 ] as both reaction medium and promoter for the between aldehyde 4-hydroxy-6-methylpyran-2-one is described. Without any added catalyst, this was realised efficiently to give arylbispyranylmethane derivatives in high yields. Alternatively, when carried out presence acetic anhydride, fused pyran were obtained. These two novel procedures have advantages such environmentally benign nature, efficiency, simple operation process mild conditions. As...
Acetylation of D-glucosamine catalysed by sulfuric acid and N-phthaloylation the glucosyl acetate yielded 1,3,4,6-tetra- O-acetyl-2-deoxy-2-phthalimido-α-D-glucopyranose. This gave corresponding pure β-glucosyl chloride upon treatment with PCl 5 -BF 3 . An anomeric chlorination thionyl combined Lewis acids (ZnCl 2 , SnCl 4 BiCl ) resulted in an α/β anomer mixture.
Abstract A mechanistically unique and serendipitously discovered reaction providing a variety of pyridine–urea hybrids via the thiophenol‐initiated uracil ring opening pyridine ring‐forming process was reported. The identification pathway through which they were formed also briefly described. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:362–368, 2009; Published online in InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20560
Abstract A new, general, and efficient method to prepare pyranopyrimidinedione nucleosides, pyranopyrimidinediones, benzopyranones is reported.
Abstract A highly efficient one‐pot three‐component synthesis of α‐aminophosphonates is presented.
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Abstract A novel, green and efficient method for the synthesis of title pyranopyridone pyranopyran derivatives using a one‐pot three‐component reaction is developed.