A5100461981- Cardiac Arrhythmias and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Chronic Myeloid Leukemia Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lymphoma Diagnosis and Treatment
- Bone health and treatments
- Lung Cancer Treatments and Mutations
- Cardiac pacing and defibrillation studies
- Prostate Cancer Treatment and Research
- Click Chemistry and Applications
- Renal and related cancers
- Immune cells in cancer
- Quinazolinone synthesis and applications
- Cardiac Fibrosis and Remodeling
- Chronic Lymphocytic Leukemia Research
- Sperm and Testicular Function
- Cancer-related Molecular Pathways
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- PI3K/AKT/mTOR signaling in cancer
- GDF15 and Related Biomarkers
- Bone Metabolism and Diseases
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
Nankai University
2022-2025
Oregon Health & Science University
2019-2024
First Affiliated Hospital of Zhengzhou University
2017-2024
State Key Laboratory of Medicinal Chemical Biology
2022-2024
Tianjin International Joint Academy of Biomedicine
2023-2024
University of Electronic Science and Technology of China
2024
Tsinghua University
2020-2023
Second Affiliated Hospital of Nanjing Medical University
2022-2023
Jiangnan University
2023
Jianghan University
2023
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T through an 'inside out' signalling process whereby structurally diverse phosphoantigen (pAg) molecules sensed by the intracellular domain of butyrophilin BTN3A11-4. Here we show how-in humans alpaca-multiple pAgs function as 'molecular glues' promote heteromeric association between domains BTN3A1 similar BTN2A1. X-ray crystallography studies visualized that engagement with forms a composite interface for direct...
Backgroud: Diabetic nephropathy is one of the most frequent causes end-stage renal disease and associated with proliferation glomerular mesangial cells (MCs) excessive production extracellular matrix (ECM). Several studies have shown that early growth response factor 1 (Egr1) plays a key role in fibrosis by regulating expression genes encoding ECM components. However, whether Egr1 also contributes to diabetic unclear.In present study, we compared kidneys from OLETF rats spontaneous type 2...
A massive intronic hexanucleotide repeat (GGGGCC) expansion in C9ORF72 is a genetic origin of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recently, C9ORF72, together with SMCR8 WDR41, has been shown to regulate autophagy function as Rab GEF. However, the precise remains unclear. Here, we report cryogenic electron microscopy (cryo-EM) structure human C9ORF72-SMCR8-WDR41 complex at resolution 3.2 Å. The reveals dimeric assembly heterotrimer C9ORF72-SMCR8-WDR41....
Cinnamaldehyde is a flavor isolated from the bark of <italic>Cinnamomum cassia</italic> Presl and exerts anti-inflammation effects in various diseases.
Abstract Background Cardiac fibrosis is significant global health problem, which associated with numerous cardiovascular diseases, and ultimately leads to the progression heart failure. β-adrenergic receptor (β-AR) overactivation play a role in development of cardiac fibrosis. Miglustat (Mig) has shown anti-fibrosis effects multiple fibrotic diseases. However, it unclear whether how Mig can ameliorate induced by β-AR overactivation. Methods In vivo, mice were injected isoproterenol (ISO)...
Skin fibrosis including keloids, which are characterized excessive deposition, abnormal proliferation, aggressiveness, and migration of the extracellular matrix dermal fibroblasts. TGF-β signaling is a classical pro-fibrotic pathway, it plays crucial part in occurrence progression skin fibrosis. Daidzein (Dai), an isoflavone compound, has been proved to possess anti-fibrosis effect by various inflammatory fibrotic diseases. However, little known about Dai on Therefore, we further explored...
Atherosclerosis (AS) is a common chronic inflammatory disease of the arteries, which closely related to dyslipidemia, factors, and oxidative stress. Poria cocos polysaccharides (PCP) are one main active ingredients Poria, has significant pharmacological effects. In this study, potential protective mechanism PCP on AS was discussed in ApoE −/− mice model induced by high‐fat diet. These pathological changes were evaluated H&E oil red O staining. The levels pro‐inflammatory cytokines aortic...
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease that seriously threatens the health of patients. The pathogenesis IPF still unclear, and there lack effective therapeutic drugs. Myofibroblasts are main effector cells IPF, leading to excessive deposition extracellular matrix (ECM) promoting progression fibrosis. Inhibiting activation relieving autophagy blockage myofibroblasts key treat IPF. PI3K/Akt/mTOR pathway plays regulatory role in...
Two distinct protein cofactors, p35 and p39, independently activate Cyclin-dependent kinase 5 (Cdk5), which plays diverse roles in normal brain function the pathogenesis of many neurological diseases. The initial discovery that loss impairs neuronal migration embryonic prompted intensive research exploring p35-dependent Cdk5 activity. In contrast, p39 expression is restricted to postnatal its remains poorly understood. Despite robustly increased activity during differentiation, activator...
Coronary heart disease is the first killer of human health. At present, most widely used approach coronary diagnosis angiography, a surgery that could potentially cause some physical damage to patients, together with complications and adverse reactions. Furthermore, angiography expensive thus cannot be in under development country. On other hand, color Doppler echocardiography report, blood biochemical indicators personal information, such as gender, age diabetes, can reflect degree patients...
Background Long term dietary consumption of genistein by Chinese men is associated with decreased PCa metastasis and mortality. Short treatment US prostate cancer (PCa) decreases MMP-2 in tissue. MEK4 regulates expression, drives metastasis, inhibits MEK4, expression dosing human mice. This study examines short- versus long-term effects humans vitro. Methods findings localized were treated on a phase II trial (N = 14) not for one month prior to radical prostatectomy. Prostate epithelial...
Fraxin, the effective component isolated from Cortex Fraxini, has been reported to have anti-inflammation effects. The aim of this study was explore effect fraxin on lipopolysaccharide (LPS)-induced endotoxic shock in mice. We used Kunming male mice establish model, and we found that could improve survival rate LPS-induced Histopathological showed mitigate injuries lung liver tissues. levels tumour necrosis factor-α interleukin-6 both serum lung, tissues, productions nitric oxide (NO),...
Traditionally, cancer-associated fibroblasts (CAFs), an essential component of tumor microenvironment, were exert a crucial part in colon cancer progression. In this study, single-cell RNA-sequencing (scRNA-seq) data from 23 and bulk RNA-seq 452 patients extracted the GEO database TCGA-COAD databases, respectively. From analysis, 825 differentially expressed genes (DEGs) CAFs identified between each pair six newly defined CAFs, named enCAF, adCAF, vaCAF, meCAF, erCAF, cyCAF. Cell...
Abstract Small molecule tyrosine kinase inhibitors (TKI) have revolutionized cancer treatment and greatly improved patient survival. However, life-threatening cardiotoxicity of many TKIs has become a major concern. Ponatinib (ICLUSIG) was developed as an inhibitor the BCR-ABL oncogene is among most cardiotoxic TKIs. Consequently, use ponatinib restricted to tumors carrying T315I-mutated BCR-ABL, which occurs in chronic myeloid leukemia (CML) confers resistance first- second-generation such...
Background: Obesity, a chronic metabolic disorder, is related to cardiovascular diseases, diabetes, cancer, and reproductive disorders. The relationship between obesity male infertility now well recognized, but the mechanisms involved are unclear. We aimed observe effect of on spermatogenesis investigate role histone ubiquitination acetylation modifications in obesity-induced Methods: Thirty C57BL/6J mice were randomly divided into two groups. control group was fed with general maintenance...
Tumor-associated macrophages (TAMs) and other myelomonocytic cells are implicated in regulating responsiveness to immunotherapies, including immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis. We have developed an ex vivo high-throughput approach discover modulators of macrophage-mediated T cell suppression, which can improve clinical outcomes ICIs. screened 1,430 Food Drug Administration (FDA)-approved small-molecule drugs using a co-culture assay employing...
(1) Background: Heart failure (HF) is the final stage of multiple cardiac diseases, which have now become a severe public health problem worldwide. β-Adrenergic receptor (β-AR) overactivation major pathological factor associated with diseases and mediates fibrosis inflammation. Previous research has demonstrated that Bruton's tyrosine kinase (BTK) mediated by TGF-β related signal pathways, indicating BTK was potential drug target for fibrosis. Zanubrutinib, second-generation inhibitor, shown...
Colorectal cancer (CRC) is mainly caused by chromosomal instability (CIN) and microsatellite (MSI). The RAS RAF genes are essential components of the CIN pathway, several studies have found that mutations associated with MSI status in CRC. Here, we examined these three factors CRC Northeast China aimed to reveal new details relationship between status.This study involved 290 patients who had or gene mutation detected using fluorescence-based allele-specific polymerase chain reaction Sanger...
Cardiac remodeling serves as the underlying pathological basis for numerous cardiovascular diseases and represents a pivotal stage intervention. The excessive activation of β-adrenergic receptors (β-ARs) assumes crucial role in cardiac remodeling. Nonetheless, molecular mechanisms governing β-AR-induced remain largely unresolved. In present study, we identified Src tyrosine kinase key player triggered by β-AR activation. Our findings demonstrated that mediates isoproterenol (ISO)-induced...