A5056840545- Plant Molecular Biology Research
- Mycotoxins in Agriculture and Food
- Liver Disease Diagnosis and Treatment
- Plant-Microbe Interactions and Immunity
- T-cell and B-cell Immunology
- Plant Pathogens and Fungal Diseases
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Plant Physiology and Cultivation Studies
- Fluid Dynamics and Turbulent Flows
- Monoclonal and Polyclonal Antibodies Research
- Plant Reproductive Biology
- Ginseng Biological Effects and Applications
- Bacterial Genetics and Biotechnology
- Photosynthetic Processes and Mechanisms
- Plant Gene Expression Analysis
- Environmental Toxicology and Ecotoxicology
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Listeria monocytogenes in Food Safety
- Plant Stress Responses and Tolerance
- Heavy metals in environment
- Research in Cotton Cultivation
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
Nanjing University of Finance and Economics
2020-2025
Nanjing Medical University
2006-2025
Jiangsu Province Hospital
2020-2025
Shanxi Agricultural University
2024
Liaoning Cancer Hospital & Institute
2015-2024
Ruijin Hospital
2015-2024
Dalian University of Technology
2023-2024
Academy of State Administration of Grain
2020-2023
Beijing Forestry University
2019-2023
Qingdao Eighth People's Hospital
2023
Abstract Motivation Fusion genes created by genomic rearrangements can be potent drivers of tumorigenesis. However, accurate identification functionally fusion from sequencing requires whole genome sequencing, since exonic alone is often insufficient. Transcriptome provides a direct, highly effective alternative for capturing molecular evidence expressed fusions in the precision medicine pipeline, but current methods tend to inefficient or insufficiently accurate, lacking sensitivity...
Radon has long been known to contribute risk of lung cancer, especially in undergound miners who are exposed large amounts the carcinogen. Recently, however, lower radon present living areas have suggested as an important cause cancer. In effort clarify relationship low with cancer risk, we placed alpha-track detectors homes 308 women newly diagnosed and 356 randomly selected female control subjects similar age. Measurements were taken after 1 year. All study participants part general...
Non-alcoholic fatty liver disease (NAFLD) is an emerging global with increasing prevalence. However, the mechanism of NAFLD development not fully understood. To elucidate cell-specific role nuclear factor erythroid-derived 2-like 2 (NRF2) in pathogenesis NAFLD, we utilized hepatocyte- and macrophage-specific Nrf2-knockout [Nrf2(L)-KO Nrf2(Mϕ)-KO] mice to examine progress induced by high-fat diet (HFD). Compared Nrf2-LoxP littermates, Nrf2(L)-KO showed less enlargement, milder inflammation...
The haplotypes in the gene vitamin K epoxide reductase complex subunit 1 (VKORC1) have been found to affect warfarin dose response through effects on formation of reduced-form K, a cofactor for gamma-carboxylation K-dependent proteins, which is involved coagulation cascade and has potential impact atherosclerosis. We hypothesized that VKORC1-dependent atherosclerosis would contribute susceptibility vascular diseases.To test hypothesis, we studied association polymorphisms VKORC1 with stroke...
A major constraint affecting the quality and productivity of chrysanthemum is unusual period low temperature occurring during early spring, late autumn, winter. Yet, there has been no systematic investigation on genes underlying response to in chrysanthemum. Herein, we used RNA-Seq platform characterize transcriptomic by comparing different transcriptome Chrysanthemum nankingense plants subjecting them a sub-zero temperature, with or without prior acclimation. Six separate libraries were...
ICE (Inducer of CBF Expression) family genes play an important role in the regulation cold tolerance pathways. In earlier study, we isolated gene CdICE1 from Chrysanthemum dichrum and demonstrated that freezing was enhanced by overexpression. Therefore, sought to determine mechanism which ICE1 participate tolerance.Using EMSA (Electrophoretic Mobility Shift Assay) yeast one-hybrid assays, confirmed binds specifically MYC element CdDREBa promoter activates transcription. addition,...
Summary For a flowering plant, the transition from vegetative stage to reproductive growth is probably most critical developmental switch. In model plant Arabidopsis thaliana , product of BBX7 group II member BBX family, acts delay floral transition. this study, presumed chrysanthemum homolog second gene AtBBX8 designated CmBBX8 had been isolated and characterized. The transcription followed diurnal rhythm as regulator. Overexpression accelerated flowering, while its (artificial microRNAs)...
Aim In the study, we investigated regulatory effects of these genes (codY, comA, degU and spo0A) on biosynthesis three lipopeptides (bacillomycin D, fengycin surfactin) in Bacillus amyloliquefaciens. Methods Results The codY, spo0A B. amyloliquefaciens fmbJ were knocked out. results showed that productions bacillomycin D significantly reduced compared with fmbJ. Their deletion induced great changes levels transcripts specifying metabolic pathways, quorum sensing system substance transport...
Globally, type 2 diabetes (T2DM) is on the rise. Maintaining a healthy diet crucial for both treating and preventing T2DM.As common vegetable in daily diet, broccoli has antioxidant, anti-inflammatory anticarcoma physiological activities. We developed mouse model of carried out systematic investigation to clarify function reducing T2DM symptoms controlling intestinal flora. The findings demonstrated that could successfully lower fasting blood glucose (FBG), lessen insulin resistance,...
Summary Changes in the V H ‐region repertoire of isolator piglets reared for 6 weeks under germ‐free (GF) conditions and those colonized (COL) with a defined exclusion flora on 1st day life were compared. Although serum immunoglobulin levels 20–100‐fold higher COL than GF piglets, an analysis peripheral blood B cells (PBBs) indicated that: used same four genes two D segments during 6‐week period; proportional usage was as fetal animals; did not differ between animals. This pattern differed...
The sequences of 34 swine H chain V-regions expressed with either IgG, IgA, or IgM C regions in adult and newborn piglets are described compared. Sixteen these were cloned by using a specific leader primer whereas 18 anchored PCR. According to the operational criterion VH family classification, i.e., > 80% DNA sequence similarity, all belong homogeneous gene family. A total 31 additional VH-bearing mu clones obtained PCR from colostrum-deprived hybridized equally probe for pan-VH probe. When...
The chrysanthemum genome harbors three FT-like genes: CmFTL1 and CmFTL3 are thought to act as regulators of floral induction under long-day (LD) short-day (SD) conditions, respectively, whereas the function CmFTL2 is currently unclear. objective present research was explore in determination flowering time photo-insensitive cultivar 'Floral Yuuka', both response variation photoperiod exogenous provision sucrose. Spraying leaves Yuuka' plants with 50 mM sucrose accelerated increased level...
Chrysanthemum, a leading ornamental species, does not tolerate salinity stress, although some of its related species do. The current level understanding regarding the mechanisms underlying tolerance in this botanical group is still limited.