A5100610347- Blood Pressure and Hypertension Studies
- MicroRNA in disease regulation
- Antibiotic Resistance in Bacteria
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Circular RNAs in diseases
- Telomeres, Telomerase, and Senescence
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Viral Infectious Diseases and Gene Expression in Insects
- Atherosclerosis and Cardiovascular Diseases
- Renal and related cancers
- Pneumonia and Respiratory Infections
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Function and Risk Factors
- Mycobacterium research and diagnosis
- Genetic and Kidney Cyst Diseases
- Gout, Hyperuricemia, Uric Acid
- Cytokine Signaling Pathways and Interactions
- Food composition and properties
- Bacterial Identification and Susceptibility Testing
- Infant Nutrition and Health
- Epigenetics and DNA Methylation
- Medical Research and Treatments
Sichuan University
2018-2024
West China Hospital of Sichuan University
2018-2024
Peking University Shenzhen Hospital
2020-2024
Sun Yat-sen University
2021-2024
Tsinghua University
2024
First Affiliated Hospital Zhejiang University
2019-2024
Zhejiang University
2007-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2017-2024
Yantaishan Hospital
2010-2024
Hong Kong University of Science and Technology
2024
Recently, the potential role of gut microbiome in metabolic diseases has been revealed, especially cardiovascular diseases. Hypertension is one most prevalent worldwide, yet whether microbiota dysbiosis participates development hypertension remains largely unknown. To investigate this issue, we carried out comprehensive metagenomic and metabolomic analyses a cohort 41 healthy controls, 56 subjects with pre-hypertension, 99 individuals primary hypertension, performed fecal transplantation...
The appropriate target for systolic blood pressure to reduce cardiovascular risk in older patients with hypertension remains unclear.
Background— Essential hypertension has been recognized as a disease resulting from combination of environmental and genetic factors. Recent studies demonstrated that microRNAs (miRNAs) are involved in cardiac hypertrophy heart failure. However, little is known about the roles miRNAs essential hypertension. Methods Results— Using microarray-based miRNA expression profiling, we compared expressions plasma samples 13 hypertensive patients 5 healthy control subjects. Twenty-seven were found to...
Oxaliplatin is a widely used chemotherapy drug for patients with advanced colorectal cancer (CRC); however, frequent resistance limits its therapeutic efficacy in patients. Here, this work identifies cyclin-dependent kinase 1 (CDK1) as critical contributor to oxaliplatin via vitro and vivo CRISPR/Cas9 screening. CDK1 highly expressed oxaliplatin-resistant cells tissues due the loss of N6-methyladenosine modification. Genetic pharmacological blockade restore susceptibility CRC...
Abstract Upper gastrointestinal (GI) hemorrhage is a common clinical emergency worldwide. Endoscopic hemostasis the current first line treatment. Nevertheless, for patients with severe active bleeding and challenging anatomy, endoscopic management can be still difficult usually requires higher level of surgical expertise. A simple effective method therefore in acute demand. Herein hemostatic hybrid hydrogel comprised hyaluronic acid polyethylene glycol stabilized by thiourea–catechol...
Pepper (Capsicum spp.) is an important vegetable crop that provides a unique pungent sensation when eaten. Through construction of pepper variome map, we examined the main groups emerged during domestication and breeding C. annuum, their relationships temporal succession, molecular events underlying transitions. The results showed initial differentiation in fruit shape pungency, increase weight, transition from erect to pendent fruits, as well recent appearance large, blocky, sweet fruits...
The haplotypes in the gene vitamin K epoxide reductase complex subunit 1 (VKORC1) have been found to affect warfarin dose response through effects on formation of reduced-form K, a cofactor for gamma-carboxylation K-dependent proteins, which is involved coagulation cascade and has potential impact atherosclerosis. We hypothesized that VKORC1-dependent atherosclerosis would contribute susceptibility vascular diseases.To test hypothesis, we studied association polymorphisms VKORC1 with stroke...
Background— Transgenic mice with cardiac-restricted overexpression of tumor necrosis factor (MHCsTNF mice) develop progressive myocardial fibrosis, diastolic dysfunction, and adverse cardiac remodeling. Insofar as (TNF) does not directly stimulate fibroblast collagen synthesis, we asked whether TNF-induced fibrosis was mediated indirectly through interactions between mast cells fibroblasts. Methods Results— Cardiac cell number increased 2 to 3 fold ( P <0.001) in MHCsTNF compared...
ANRIL encodes a long antisense noncoding RNA in the INK4 locus. Although has been proven to be associated with coronary heart disease, its roles stroke are inconsistent, and sparse data available regarding hemorrhagic stroke.A Chinese case-control study was conducted, comprising 1657 cases (724 atherothrombosis, 466 lacunar infarction, 462 strokes) 1664 controls. Stroke patients were prospectively followed-up for median of 4.5 (range, 0.1-6.0) years. Expression transcripts examined 42 human...
In this study, we aimed to investigate whether and how lncRNA CASC2 was involved in hypoxia-induced pulmonary hypertension (PH)-related vascular remodeling. The expression of lncRNAs or mRNAs detected by qRT-PCR, western blot analysis immunochemistry employed for detecting the protein expression. Cell number assay EdU (5-ethynyl-2′-deoxyuridine) staining were performed assess cell proliferation. Besides, flow cytometry wound healing assessments apoptosis migration, respectively. Rat model...
Abstract In type 1 and 2 diabetes mellitus, increased cardiac fibrosis, stiffness associated diastolic dysfunction may be the earliest pathological phenomena in diabetic cardiomyopathy. Endothelial‐mesenchymal transition (EndMT) endothelia cells (ECs) is a critical cellular phenomenon that increases fibroblasts (CFs) fibrosis hearts. The purpose of this paper to explore molecular mechanism miR‐21 regulating EndMT perivascular vivo, hyperglycaemia up‐regulated mRNA level , aggravated collagen...
Abstract The global coronavirus disease 2019 (COVID-19) pandemic has led to a health crisis. It remains unclear how anxiety affects blood pressure (BP) and cardiovascular risk among older patients with hypertension. In this study, we extracted longitudinal data on home BP monitored via smartphone-based application in 3724 elderly hypertension from clinical trial (60–80 years; 240 Wuhan 3484 non-Wuhan areas) examine changes morning during the COVID-19 outbreak China. Anxiety was evaluated...
This study identified the function of neural precursor cell expressed developmentally down-regulated 4-like (NEDD4L) on bladder cancer (BLCA).NEDD4L expression in BLCA patients was scrutinized. The NEDD4L viability, apoptosis, migration and invasion cells evaluated by counting kit-8, flow cytometry Transwell assays. effect cisplatin (DDP) resistance DDP-resistant explored. influence p62/Keap1/Nrf2 pathway activity tested Western blot. Rescue experiments were implemented to verify whether...
Neutrophil extracellular traps (NETs) have been categorized as a form of inflammatory cell death mode neutrophils (NETosis) involved in natural immunity and the regulation adaptive immunity. More more studies revealed ability NETs to reshape tumor immune microenvironment (TIME) by limiting antitumor effector cells, which may impair efficacy immunotherapy. To explore whether NETs-related genes make vital impacts on Colon carcinoma (COAD), we carried out systematic analysis showed several...
Elizabethkingia is emerging as an opportunistic pathogen in humans. The aim of this study was to investigate the clinical epidemiology, antimicrobial susceptibility, virulence factors, and genome features spp.
Plasma homocysteine concentrations have been associated with the risk of stroke, but its relevance to secondary vascular events and mortality after stroke remains unclear because inconsistent results from clinical trials. The aim present study was investigate whether plasma levels MTHFR (methylenetetrahydrofolate reductase) variant C677T contributed recurrence all-cause in a large prospective cohort patients Chinese population. A total 1823 (age, 35-74 years) were recruited during 2000-2001...
Pyogenic liver abscess (PLA) is a potentially life-threatening disease affecting many parts of the world, especially Asia. In this study, we explored clinical and microbiological characteristics PLA in Chinese patients. A 5-year (2010–2014) retrospective review medical records on all patients who were admitted to tertiary teaching hospital was performed. Among 217 cases confirmed cultural positive, Klebsiella pneumonia (K pneumonia) most common pathogen (n = 165, 76.0%), followed by...