A5045824703- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
- Surgical Sutures and Adhesives
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Pickering emulsions and particle stabilization
- Tissue Engineering and Regenerative Medicine
- Advanced Drug Delivery Systems
- Cellular Mechanics and Interactions
- Advanced Cellulose Research Studies
- Extracellular vesicles in disease
- Hemostasis and retained surgical items
- Bone Tissue Engineering Materials
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Pigment Synthesis and Properties
- Osteoarthritis Treatment and Mechanisms
- Laser Material Processing Techniques
- Additive Manufacturing and 3D Printing Technologies
- Advanced Photocatalysis Techniques
- TiO2 Photocatalysis and Solar Cells
- Cell Image Analysis Techniques
- Photochromic and Fluorescence Chemistry
- Nonlinear Optical Materials Studies
- Infectious Aortic and Vascular Conditions
Chinese University of Hong Kong
2017-2024
South China University of Technology
2024
Jingdezhen Ceramic Institute
2014
Abstract Achieving rapid and effective hemostasis on irregularly shaped, non‐compressible visceral, high‐pressure arterial bleeding wounds remains a critical clinical challenge. Herein, an ultrafast self‐gelling wet adhesive polyethyleneimine/polyacrylic acid/quaternized chitosan (PEI/PAA/QCS) powder is reported as the hemostatic material wound dressing. PEI/PAA/QCS deposited can rapidly absorb large amount of blood to concentrate coagulation factors. Meanwhile, form hydrogel in situ within...
Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because the interfering interfacial water limited adhesive-tissue interactions. Here we report self-gelling adhesive polyethyleneimine polyacrylic acid (PEI/PAA) powder, which can absorb to form physically cross-linked hydrogel in situ within 2 seconds due physical interactions between polymers. Furthermore, polymers diffuse into substrate polymeric network enhance adhesion. Superficial...
Bioadhesive hydrogel with ultrafast gelation independent of environmental pH is endoscopically delivered to enhance gastric ulcer healing.
Abstract 3D culture of cells in designer biomaterial matrices provides a biomimetic cellular microenvironment and can yield critical insights into behaviours not available from conventional 2D cultures. Hydrogels with dynamic properties, achieved by incorporating either degradable structural components or reversible crosslinks, enable efficient cell adaptation the matrix support associated functions. Herein we demonstrate that given similar equilibrium binding constants, hydrogels containing...
A key challenge for the effective treatment of gastrointestinal diseases including inflammatory bowel disease is to develop an orally administered drug delivery system capable prolonged retention in tract. Herein we report a bioadhesive liquid coacervate based on hydrogen bonding-driven nanoparticle assembly. Free from electrostatic interactions, our fluid nanoparticle-assembled demonstrates significant pH- and salt-independent structural stability forms physically adhesive coating large...
There has been a compelling demand of fabricating high-resolution complex three-dimensional (3D) structures in nanotechnology. While two-photon lithography (TPL) largely satisfies the need since its introduction, low writing speed and high cost make it impractical for many large-scale applications. We report digital holography-based TPL platform that realizes parallel printing with up to 2000 individually programmable laser foci fabricate 3D 90 nm resolution. This effectively improves...
Nanocomposite hydrogels consist of a polymer matrix embedded with nanoparticles (NPs), which provide the unique bioactivities and mechanical properties. Incorporation NPs via in situ precipitation further enhances these desirable hydrogel However, noncytocompatible pH, osmolality, lengthy duration typically required for such strategies preclude cell encapsulation resultant hydrogels. Bisphosphonate (BP) exhibits variety specific excellent binding affinity to multivalent cations as magnesium...
Precise diagnosis and effective treatment of gliomas still remain a huge challenge. Photoacoustic-guided photothermal therapy (PTT) has unique advantages over conventional techniques for brain tumor theranostics, but existing nanoagents photoacoustic imaging (PAI)-guided PTT are mainly organic small molecules or inorganic nanoparticles, which have the limitations poor photostability biocompatibility. Besides, restricted absorption in first near-infrared window (NIR-I) most compromises their...
Abstract Upper gastrointestinal (GI) hemorrhage is a common clinical emergency worldwide. Endoscopic hemostasis the current first line treatment. Nevertheless, for patients with severe active bleeding and challenging anatomy, endoscopic management can be still difficult usually requires higher level of surgical expertise. A simple effective method therefore in acute demand. Herein hemostatic hybrid hydrogel comprised hyaluronic acid polyethylene glycol stabilized by thiourea–catechol...
Functionalized cellulose-based materials are in high demand for many applications. In this work, we report a green approach to fabricate type of versatile material through facile citric acid/cysteine treatment. For its preparation, were conjugated with acid/cysteine-based fluorophores (CCFs) by simply soaking them concentrated aqueous solution followed drying above 80 °C. Chemical modification occurred, which was completed the swollen state cellulose, and highest conjugating ratio reached...
Abstract In situ and cytocompatible nanoswitching by external stimuli is highly appealing for reversibly regulating cellular adhesion functions in vivo. Here, a heterodimeric nanoswitch designed to facilitate switchable combinatorial presentation of integrin‐binding cell‐adhesive moieties, such as Mg 2+ Arg‐Gly‐Asp (RGD) ligand nanostructures. reversible controlled convertible coordination between bioactive bisphosphonate (BP) ligand. A BP‐coated gold‐nanoparticle monomer (BP‐AuNP) on...
Osteoporotic bone defects pose a significant challenge for regeneration as they exhibit impaired healing capacity and delayed period. To address this issue, study introduces hydrogel that creates rejuvenating microenvironment, thereby facilitating efficient repair during the initial two weeks following defect surgery. The hydrogel, named GelHFS, was created through host-guest polymerization of gelatin acrylated β-cyclodextrin. Incorporation human fetal mesenchymal stem cell secretome (HFS)...
Membraneless coacervate compartments in the intracellular and pericellular space mediate critical cellular functions. Developing synthetic coacervates that emulate morphological, physical, functional complexity of these natural is challenging but highly desirable. Herein, a generalizable nanoparticle assembly (NPA) strategy developed, which applicable to interactive core-shell nanoparticles with different chemical makeups, fabricate vacuolated coacervates. The obtained NPA contain stable...
The symptoms of knee osteoarthritis (KOA) severely affect the life quality elderly population. Low-level laser therapy, heat and massage therapy are widely used as independent treatments for joint disorders. However, there very limited reports a combination these therapies into an integrated device KOA so far. This study aims to develop novel hybrid therapeutic that can meet various requirements therapy. Our (CUHK-OA-M2) with low-level local effectively provide patients relief from their...
Three-dimensional (3D) printing, also known as additive manufacturing (AM), has undergone a phase of rapid development in the fabrication customizable and high-precision parts. Thanks to advancements 3D printing technologies, it is now reality print cells, growth factors, various biocompatible materials altogether into arbitrarily complex scaffolds with high degree structural functional similarities native tissue environment. Additionally, overpowering advantages molding efficiency,...
Abstract Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical need due to the interfering interfacial water lack adhesive–tissue interactions. Herein we report self-gelling adhesive polyethyleneimine polyacrylic acid (PEI/PAA) powder, which can absorb rapidly form physically crosslinked hydrogel in situ within two seconds physical interactions between polymers. Furthermore, polymers diffuse into substrate polymeric network enhance various...
Fast and accurate drug screening can significantly improve the survival rate of cancer patients. Here, we present a new platform for treatment based on an integrated precision microtome LiMo microscope. Through this platform, tumor specimens from patients are first sectioned into 100-micron thick tissue slices cultured few days; next, live array is tested with different anti-cancer drugs weeks regularly 3D imaged at subcellular resolution, realizing personalized medicine. Our preliminary...