A5101715242- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Advanced Sensor and Energy Harvesting Materials
- Nanoplatforms for cancer theranostics
- Advanced Materials and Mechanics
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Semiconductor materials and interfaces
- Analytical Chemistry and Chromatography
- Supramolecular Self-Assembly in Materials
- Surgical Sutures and Adhesives
- Pickering emulsions and particle stabilization
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- Electrospun Nanofibers in Biomedical Applications
- Biological and pharmacological studies of plants
- Cell Adhesion Molecules Research
- Advanced Drug Delivery Systems
- Conducting polymers and applications
- Semiconductor materials and devices
- Silicon Nanostructures and Photoluminescence
- Autonomous Vehicle Technology and Safety
- Advanced Chemical Sensor Technologies
- Liquid Crystal Research Advancements
- Nanofabrication and Lithography Techniques
South China University of Technology
2022-2024
Xidian University
2023-2024
China Automotive Technology and Research Center
2022-2024
Chinese University of Hong Kong
2016-2023
Henan University of Science and Technology
2023
Kunming Medical University
2021-2023
State Council of the People's Republic of China
2016-2020
Shatin Hospital
2017
Shandong University
2004-2015
Dalian Minzu University
2011-2012
Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because the interfering interfacial water limited adhesive-tissue interactions. Here we report self-gelling adhesive polyethyleneimine polyacrylic acid (PEI/PAA) powder, which can absorb to form physically cross-linked hydrogel in situ within 2 seconds due physical interactions between polymers. Furthermore, polymers diffuse into substrate polymeric network enhance adhesion. Superficial...
Bioadhesive hydrogel with ultrafast gelation independent of environmental pH is endoscopically delivered to enhance gastric ulcer healing.
Abstract 3D culture of cells in designer biomaterial matrices provides a biomimetic cellular microenvironment and can yield critical insights into behaviours not available from conventional 2D cultures. Hydrogels with dynamic properties, achieved by incorporating either degradable structural components or reversible crosslinks, enable efficient cell adaptation the matrix support associated functions. Herein we demonstrate that given similar equilibrium binding constants, hydrogels containing...
A key challenge for the effective treatment of gastrointestinal diseases including inflammatory bowel disease is to develop an orally administered drug delivery system capable prolonged retention in tract. Herein we report a bioadhesive liquid coacervate based on hydrogen bonding-driven nanoparticle assembly. Free from electrostatic interactions, our fluid nanoparticle-assembled demonstrates significant pH- and salt-independent structural stability forms physically adhesive coating large...
Abstract Owing to the unique advantages of photoacoustic imaging (PAI) and photothermal therapy (PTT) conducted over near‐infrared‐II (NIR‐II) window, development high‐efficiency optical agents with NIR‐II light responsiveness is great significance. Despite diversity developed for PAI PTT, most them are based on inorganic nanomaterials small molecular dyes, whose biosafety photostability need be further assessed, respectively. Organic semiconducting macromolecular dyes (OSMDs) featuring a...
Abstract Effective and easy regulation of hydrogel surface properties without changing the overall chemical composition is important for their diverse applications but remains challenging to achieve. We report a generalizable strategy reconfigure networks based on hydrogel–substrate interface dynamics manipulation wettability bioadhesion. show that grafting hydrophobic yet flexible polymeric chains mold substrates can significantly elevate content polymer backbones reduce presence polar...
Photoacoustic (PA) imaging and tracking of stem cells plays an important role in the real-time assessment cell-based therapies. Nevertheless, limitations conventional inorganic PA contrast agents narrow range excitation wavelength first near-infrared (NIR-I) window hamper applications living subjects. Herein, we report design synthesis a second (NIR-II) absorptive organic semiconducting polymer (OSP)-based nanoprobe (OSPN+) for cells. Comparison studies biological tissue show that NIR-II...
Folded single chain polymeric nano-objects are the molecular level soft material with ultra-small size. Here, we report an easy and scalable method for preparing single-chain nanogels (SCNGs) improved efficiency. We further investigate impact of dynamic conformational change SCNGs on cellular interactions from to bulk scale. First, supramolecular unfoldable efficiently deliver siRNAs into stem cells as a drug carrier in conformation-dependent manner. Furthermore, conformation changes enable...
Abstract Upper gastrointestinal (GI) hemorrhage is a common clinical emergency worldwide. Endoscopic hemostasis the current first line treatment. Nevertheless, for patients with severe active bleeding and challenging anatomy, endoscopic management can be still difficult usually requires higher level of surgical expertise. A simple effective method therefore in acute demand. Herein hemostatic hybrid hydrogel comprised hyaluronic acid polyethylene glycol stabilized by thiourea–catechol...
Abstract Cellular energetics plays an important role in tissue regeneration, and the enhanced metabolic activity of delivered stem cells can accelerate repair regeneration. However, conventional hydrogels with limited network cell adaptability restrict cell–cell interactions activities. In this work, it is shown that a cell‐adaptable hydrogel high dynamics enhances glucose uptake fatty acid β ‐oxidation encapsulated human mesenchymal (hMSCs) compared low dynamics. It further hMSCs dynamic...
Mussel-mimetic hydrogels possessing ultrahigh adhesion energy on wet biological tissues <italic>via</italic> enhancing both the interfacial and bulk cohesion are fabricated.
Coacervation driven liquid-liquid phase separation of biopolymers has aroused considerable attention for diverse applications, especially the construction microstructured polymeric materials. Herein, a coacervate-to-hydrogel transition strategy is developed to create macroporous hydrogels (MPH), which are formed via coacervation process supramolecular assemblies (SA) built by host-guest complexation between γ-cyclodextrin and anthracene dimer. The weak reversible crosslinks endow SA with...
Osteosarcoma is an aggressive malignant tumor that primarily develops in children and adolescents. The conventional treatments for osteosarcoma often exert negative effects on normal cells, chemotherapeutic drugs, such as platinum, can lead to multidrug resistance cells. Herein, this work reports a new bioinspired tumor-targeting enzyme-activatable cell-material interface system based DDDEEK-pY-phenylboronic acid (SAP-pY-PBA) conjugates. Using tandem-activation system, selectively regulates...
Functionalized cellulose-based materials are in high demand for many applications. In this work, we report a green approach to fabricate type of versatile material through facile citric acid/cysteine treatment. For its preparation, were conjugated with acid/cysteine-based fluorophores (CCFs) by simply soaking them concentrated aqueous solution followed drying above 80 °C. Chemical modification occurred, which was completed the swollen state cellulose, and highest conjugating ratio reached...
Developing magnetic ultrasoft robots to navigate through extraordinarily narrow and confined spaces like capillaries in vivo requires synthesizing materials with excessive deformability, responsive actuation, rapid adaptability, which are difficult achieve the current soft polymeric materials, such as elastomers hydrogels. We report a magnetically actuatable water-immiscible (MAWI) coacervate based on assembled core-shell nanoparticles function liquid robot. The degradable biocompatible...
Pulsed electromagnetic field therapy, or pulsed signal has shown efficacy in treating many illnesses, including knee osteoarthritis. Although the mechanism is not fully understood, magnetic therapy broadly welcomed because of its safe and noninvasive nature. At cellular molecular level, remote control cell fate by also profound applications both basic science translational research. Here we demonstrate use field, one most benign extracellular cues, as a novel method to specific chondrogenic...
Mussel adhesion has inspired the development of catechol-based adhesive polymers. However, conventional strategies require basic pH conditions and lead to loss adhesion. To solve problem, we report first attempt use thiourea-functionalized polymers for preserving hydrogel We believe that this simple thiourea-quinone coupling chemistry is instrumental synthetic materials.
Resembling soft tissues, stretchable hydrogels are promising biomaterials for many biomedical applications due to their excellent mechanical robustness. However, conventional with a synthetic polymer matrix usually bioinert. The lack of cell and tissue adhesiveness such limits applications. An easy but reliable postgelation functionalization method is desirable. Herein, we report the fabrication supramolecular cross-linked by multivalent host-guest interactions. Such containing thiourea (...
Multi-phased, ultra-tough, and self-healing elastomers containing rigid double-locked hydrophobic nanodomains reinforced by iron–catechol complexes exhibit fast stimuli-responsive shape changing.
Abstract It remains a challenge to generate cold, atmospheric pressure plasmas in sealed packages for biological disinfection. In this paper, we report plasma device form large‐area and atmospheric‐pressure package the low‐temperature disinfection of fungi . The visually uniform were easily generated portable plastic bag containing Candida albicans with population 10 5 spores placed on device. He about 1% O 2 was found entirely kill resistant treatment time min. Measurements optical emission...
Extracellular matrix (ECM) undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been explored. Here we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo