A5029504523- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- RNA Interference and Gene Delivery
- Pesticide Exposure and Toxicity
- Radical Photochemical Reactions
- Mesenchymal stem cell research
- Autism Spectrum Disorder Research
- Chemical Synthesis and Analysis
- Periodontal Regeneration and Treatments
- Sulfur-Based Synthesis Techniques
- Cancer-related molecular mechanisms research
- Synthesis and Catalytic Reactions
- Circular RNAs in diseases
- Metabolomics and Mass Spectrometry Studies
- Silk-based biomaterials and applications
- Oxidative Organic Chemistry Reactions
- Electrospun Nanofibers in Biomedical Applications
- Environmental Toxicology and Ecotoxicology
- Epigenetics and DNA Methylation
- Soil Carbon and Nitrogen Dynamics
- Lipid Membrane Structure and Behavior
Northeast Normal University
2019-2025
Jining Medical University
2023-2025
Institute of Precision Mechanics
2025
Shenzhen KangNing Hospital
2017-2025
First Affiliated Hospital of Bengbu Medical College
2022-2024
Shenzhen Second People's Hospital
2016-2024
Chinese University of Hong Kong
2016-2024
Jinzhou Kangning Hospital
2018-2024
Northwest A&F University
2023-2024
Affiliated Hospital of Jining Medical University
2022-2024
Targeted delivery to the diseased cell or tissue is key successful clinical use of nucleic acid drugs. In particular, microRNA-140 (miRNA-140, miR-140) into chondrocytes across dense, nonvascular extracellular matrix cartilage remains a major challenge. Here, we report chondrocyte-targeting exosomes as vehicles for miR-140 new treatment osteoarthritis (OA). By fusing chondrocyte-affinity peptide (CAP) with lysosome-associated membrane glycoprotein 2b protein on surface exosomes, acquire...
The construction of carbon–heteroatom bonds is one the most active areas research in organic chemistry because function molecules often derived from presence heteroatoms. Although considerable advances have recently been achieved radical-involved catalytic asymmetric C–N bond formation, there has little progress corresponding C–O bond-forming processes. Here, we describe a photoinduced copper-catalyzed cross-coupling readily available oxime esters and 1,3-dienes to generate diversely...
Synthesis of bicyclic scaffolds has attracted growing interest because they are high importance in modern pharmaceutical development. Here we report a strategy to access polysubstituted 2-oxabicyclo[2.1.1]hexanes single operation from readily accessible benzoylformate esters and bicyclo[1.1.0]butanes via visible-light-induced triplet energy transfer catalysis. The process is proposed involve formal [2π + 2σ] photocycloaddition/backbone C-H abstraction/aryl group migration sequence. A diverse...
Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-associated cells, so hereditable genome reactions are confined within these cells without affecting healthy cells. hybrid exosome-based nano-sized derived by fusion engineered exosomes and liposomes will be able encapsulate deliver CRISPR/Cas9 plasmids selectively chondrocytes embedded in articular cartilage attenuate condition damage. Methods: Chondrocyte-targeting (CAP-Exo) were constructed...
Plant-derived exosome-like nanoparticles (PDENs) have been paid great attention in the treatment of ulcerative colitis (UC). As a proof concept, we isolated and identified Portulaca oleracea L-derived (PELNs) from edible L, which exhibited desirable nano-size (~ 160 nm) negative zeta potential value (-31.4 mV). Oral administration PELNs effectively suppressed expressions pro-inflammatory cytokines (TNF-α, IL-6, IL-12, IL-1β) myeloperoxidase (MPO), increased levels anti-inflammatory cytokine...
Abstract Messenger RNA (mRNA) has emerged as a promising therapeutic molecule with numerous clinical applications in treating central nervous system disorders, tumors, COVID-19, and other diseases. mRNA therapies must be encapsulated into safe, stable, effective delivery vehicles to preserve the cargo from degradation prevent immunogenicity. Exosomes have gained growing attention because of their good biocompatibility, low immunogenicity, small size, unique capacity traverse physiological...
An efficient and regioselective ruthenium-catalyzed oxidative annulation of enamides with alkynes via the cleavage C(sp2)–H/N–H bonds is reported. The reactions can afford N-acetyl substituted or N-unsubstituted pyrroles by altering reaction conditions slightly.
An efficient Pd-catalyzed oxime ether directed ortho C–H hydroxylation of arenes under neutral conditions has been developed. The efficiency this is significantly improved by a ligand. Oxone, an inexpensive, readily available, and safe reagent, was employed as terminal oxidant oxygen source. challenging electron-deficient substrates could also be monohydroxylated in high efficiency. Drug modification with protocol successfully demonstrated.
A diverse collection of copper-catalyzed intermolecular aminative difunctionalizations unactivated alkenes with N-halodialkylamines as the terminal dialkylamino source is reported. bidentate auxiliary tethered on alkene substrates crucial, which can promote migratory insertion nonactivated into aminyl radical–metal complex and stabilize resultant high-valent copper intermediate to allow for further transformations. By employing this strategy, aminohalogenation reactions a three-component...
The hUCB-MSC-laden 3D printed gelatin/HAP scaffold effectively repairs knee cartilage defects in a pig model.
Estrogen deficiency is closely related to the development of menopausal arthritis. replacement therapy (ERT) shows a protective effect against osteoarthritis. However, underlying mechanism this unknown. This study aimed determine role miR-140 in estrogen-dependent regulation MMP-13 human chondrocytes.
BACKGROUND Estrogen levels regulate changes in osteoarthritis (OA) by inhibiting degradation of the extracellular matrix. Recent vitro studies have also shown role microRNA-140-5p (miR-140-5p). This study aimed to investigate estrogen deficiency, selective modulation expression receptor (ER), and miR-140-5p cartilage subchondral bone remodeling an ovariectomized rat model postmenopausal OA. MATERIAL AND METHODS Female Sprague-Dawley rats included two groups, (OVX) with destabilization medial...