A5065506629- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Silk-based biomaterials and applications
- Osteoarthritis Treatment and Mechanisms
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Electromagnetic Fields and Biological Effects
- Magnetic and Electromagnetic Effects
- Knee injuries and reconstruction techniques
- Orthopaedic implants and arthroplasty
- Circular RNAs in diseases
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Cell Adhesion Molecules Research
- Soft tissue tumor case studies
- biodegradable polymer synthesis and properties
- Additive Manufacturing and 3D Printing Technologies
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Facial Trauma and Fracture Management
- High Altitude and Hypoxia
- Cytokine Signaling Pathways and Interactions
- Tendon Structure and Treatment
Shenzhen University Health Science Center
2021-2023
Shenzhen Second People's Hospital
2015-2023
University Town of Shenzhen
2021-2023
Tsinghua University
2021-2023
Chinese University of Hong Kong
2021-2022
National Science Center
2021
Shenzhen University
2018-2020
Guangzhou Medical University
2015
Shenzhen Blood Center
2013-2014
Chinese Academy of Sciences
2008
The hUCB-MSC-laden 3D printed gelatin/HAP scaffold effectively repairs knee cartilage defects in a pig model.
Artificial skins are biomaterials that can replace the lost skin or promote regeneration of damaged skin. Skin regenerative highly applauded because they exempt patients with severe burns from painful procedure autologous transplantation. Notwithstanding decades research, biocompatible, degradable, and printable effectively as a transplantation replacement in clinical use still scarce. Here, we report one type all-protein hydrogel material product enzymatic crosslinking reaction gelatin...
Scaffolds play an important role in tissue engineering and their structure biocompatibility have great influence on cell behaviors. In this study, poly(l-lactide-co-
Hydrogel is an important scaffold material in regenerative medicine and cartilage tissue engineering. combined with pulse electromagnetic fields (PEMFs), PEMFs has the potential to manage repair of defective articular cartilage. Here, we developed a new type magnetic hydrogel. The data shows that hydrogel had good mechanical properties, its surface micropores unevenness, which was conducive cell adhesion growth. Infrared spectroscopy analysis showed particles were evenly distributed...
Pulsed electromagnetic field therapy, or pulsed signal has shown efficacy in treating many illnesses, including knee osteoarthritis. Although the mechanism is not fully understood, magnetic therapy broadly welcomed because of its safe and noninvasive nature. At cellular molecular level, remote control cell fate by also profound applications both basic science translational research. Here we demonstrate use field, one most benign extracellular cues, as a novel method to specific chondrogenic...
This study was conducted to investigate the effect of magnetic nanoparticle composite scaffold under a pulsed electromagnetic field on bone marrow mesenchymal stem cells (BMSCs), which achieved by examining biological behaviors cell adhesion, proliferation and differentiation surface scaffolds. may provide some experimental evidence for use nanoparticles in medical application. The scaffolds were evaluated characterized following indexes: detected CCK-8 method, alkaline phosphatase (ALP)...
A body of evidence has indicated that microRNAs (miRNAs) may have significant roles in cancer. Aberrant expression miRNAs frequently been observed various human malignancies, including osteosarcoma (OS). However, the OS remain poorly understood. In present study, high‑throughput deep sequencing was performed to screen for deregulated OS. Screening identified 310 which were significantly overexpressed and 41 downregulated (>2‑fold) samples, compared with adjacent non‑tumor bone tissues. Among...
Objective: To study the clinical effect of bone defect treated with nano-hydroxyapatite(Nano-HA) artificial bone. Methods: From September 2009 to June 2012, 27 cases were analyzed retrospectively. The position included humerus, radius, ulna, femur, tibia and calcaneus. range was from 0.3 × 1.0 cm 3 6.5 cm. Among them, there 22 fractures 5 tumors. All patients Nano-HA ability repair evaluated by X-ray exams performed preoperatively postoperatively. HSS scores adopted for final evaluation at...
The aim of the present study was to investigate clinical significance hsa-microRNA-124-3p (miR-124) in osteosarcoma (OS), and examine its role cell growth invasion. Using a microRNA chip array, expression miR-124 detected samples surgically resected OS matched against levels tumor-adjacent normal tissues. were upregulated cells through transfection mimics. Cell proliferation Transwell assays performed determine invasion; Reverse transcription-quantitative polymerase chain reaction, western...
When preliminary tests have confirmed a nano-hydroxyapatite (Nano-HA) content of 20% the polylactic acid (PLA) composite material Nano-HA interface fixation for biomechanical requirements, there is need further observation its biocompatibility and clinical applications, to provide reference data.Preparation PLA bone substitute extract. The establishment negative control group (containing 10% fetal bovine serum in DMEM complete medium), experimental (extract), positive (mass concentration...
Objective: By in situ polymerization of poly-L-lactic acid (PLLA) and nano-hydroxyapatite (Nano-HA), finding the best proportion composite, so as to get ideal interface fixation material. Methods: According a certain ratio (the mass fraction Nano-HA, respectively, is 0%, 10%, 20%, 30% 40%), composite PLLA Nano-HA by polymerization, test performance this kind new type such as, bending strength,compressive strength, elastic modulus, scanning electron microscopy (SEM) degradation experiments...
The construction of bioactive scaffolds with a suitable microenvironment for tissue regeneration provides great promise improving clinical treatment osteochondral and full-thickness articular cartilage defects. Hydrogels polysaccharides, such as alginate, agarose, chitosan, cellulose, hyaluronic acid, dextran, biomimic the structure extracellular matrix (ECM), are exceptionally biocompatible scaffold material regeneration. application polysaccharide hydrogels combined 3-dimensional (3D)...
Nowadays more and small transistors make microprocessors susceptible to transient faults, then induce control-flow errors. Software-based signature monitoring is widely used for error detection. When previous techniques are applied RISC architectures, there exist some branch-errors that they can not detect. This paper proposes a novel software-based technique: CFC-End (Control-Flow Checking in the End). One property of it uses two global registers storing run-time alternately. Another...