A5006573763- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- Multiple Myeloma Research and Treatments
- Dendrimers and Hyperbranched Polymers
- Hydrogels: synthesis, properties, applications
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- biodegradable polymer synthesis and properties
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- Acute Kidney Injury Research
- Lipid Membrane Structure and Behavior
- Protein Degradation and Inhibitors
- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Advanced Polymer Synthesis and Characterization
- Nanocluster Synthesis and Applications
- Cancer therapeutics and mechanisms
State Key Laboratory of Biotherapy
2014-2024
Sichuan University
2014-2024
West China Hospital of Sichuan University
2022
Guangdong Pharmaceutical University
2016
Wenzhou Medical University
2016
First Affiliated Hospital of Wenzhou Medical University
2016
Stony Brook University
1992-2003
State University of New York
1992
The combination of chemotherapy with photodynamic therapy (PDT) has attracted broad attention as it can overcome limitations conventional chemo-treatment by using different modes action. However, the efficacy PDT to treat solid tumors is severely affected hypoxia in tumors.
Abstract In this study, a series of injectable thermoreversible and thermogelling PDLLA-PEG-PDLLA copolymers were developed systematic evaluation the system both in vitro vivo was performed. The aqueous solutions above critical gel concentration could transform into hydrogel spontaneously within 2 minutes around body temperature or . Modulating molecular weight, block length polymer adjust sol-gel transition behavior mechanical properties hydrogels. gelation thermally reversible due to...
Abstract Owing to the limited repair capacity of articular cartilage, it is essential develop tissue-engineered cartilage for patients suffering from joint disease and trauma. Herein, we prepared a novel hybrid scaffold composed methacrylated chondroitin sulfate (CSMA), poly(ethylene glycol) methyl ether-ε-caprolactone-acryloyl chloride (MPEG-PCL-AC, PECA was used as abbreviation MPEG-PCL-AC) graphene oxide (GO) evaluated its potential application in tissue engineering. To mimic natural...
Abstract Minimizing drug leakage in systemic circulation, synchronizing the vivo fate of multiple drugs, and precisely controlling tumor locoregional release, remain challenging for nanomedicine‐based cancer therapy. Here, a reactive oxygen species (ROS)‐responsive camptothecin (CPT) prodrug delivery system (MPEG‐(TK‐CPT)‐PPa) is developed, which CPT photosensitizer pyropheophorbide‐a (PPa) are concurrently conjugated to same poly(ethylene glycol) methyl ether (MPEG) via ROS‐responsive...
Smart hydrogels that undergo structural changes in response to stimuli (for example, pH, heat, light) have promising biomedical applications as delivery systems, especially for the locally controlled release of drugs. Early prevention locoregional recurrence (LRR) is critical patients who undergone breast-conserving therapy. This work reports preparation a hybrid hydrogel system which gold nanorods (GNRs) were doped into thermally responsive hydrogel. A near-infrared (NIR) laser was used...
Photothermal therapy (PTT) is proved to be an efficient manner for superficial tumor in preclinical studying.The suppression of chemotherapy can enhanced by combining with PTT.In this study, we reported a mesoporous magnetic gold "nanoclusters" (MMGNCs) structure as theranostic carrier chemo-photothermal co-therapy.MMGNCs were successfully prepared and they exhibited photo-thermal effect PTT.The provided MMGNCs high drug loading capacity.By vitro cytotoxicity testing, revealed that the...
Multiple myeloma (MM) is the second most common hematological malignancy. It characterized by abnormal transformation and uncontrolled clonal proliferation of malignant plasma cells in bone marrow (BM), which can destroy structure inhibit hematopoiesis. Although there are new therapeutic methods, they not curative, mainly because it difficult to deliver an effective amount drug BM, leading a failure eradicate MM inside BM. BM homing important unique characteristic affected surface molecules...
Abstract Peptide‐drug conjugates (PDCs) are an important class of therapeutic agents that combine one or more active molecules with a short peptide via biodegradable spacer to generate prodrugs. Here antioxidant (i.e., 3,5‐dihydroxybenzoic acid), non‐steroidal anti‐inflammatory drug ibuprofen, IPF), and self‐assembled motif Gly‐Phe‐Phe‐Tyr‐Asp, GFFYD) integrated produce peptide‐drug amphiphile, which self‐assembles form hydrogel further exerts the synergistic effects, consequently emerges...
Improving the efficacy of melanoma treatment remains an important global challenge. Here, we combined chemotherapy with protein tyrosine phosphatase nonreceptor type 2(Ptpn2) based immunotherapy in effort to address this Short-hairpin RNA (shRNA) targeting Ptpn2 was coencapsulated doxorubicin (DOX) cell membrane M1 macrophages (M1HD@RPR). The prepared nanoparticles (NPs) were effectively phagocytosed by B16F10 cells and macrophages, but not M0 macrophages. Hence, NP evasion from...
Abstract Bone defects in osteoporosis usually present excessive reactive oxygen species (ROS), abnormal inflammation levels, irregular shapes and impaired bone regeneration ability; therefore, osteoporotic are difficult to repair. In this study, an injectable thermosensitive hydrogel poly (D, L‐lactide)‐poly (ethylene glycol)‐ L‐lactide) (PLEL) system containing resveratrol (Res) dexamethasone (DEX) is designed create a microenvironment conducive osteogenesis defects. This PLEL injected...
Surgical resection remains the prefer option for bladder cancer treatment. However, effectiveness of surgery is usually limited high recurrence rate and poor prognosis. Consequently, intravesical chemotherapy synergize with immunotherapy in situ an attractive way to improve therapeutic effect. Herein, a combined strategy based on thermo-sensitive PLEL hydrogel drug delivery system was developed. GEM loaded instilled kill tumor cells directly, then incorporated CpG injected into both groins...
Abstract Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition targeting capabilities, potential for immunotherapy. Herein, we introduce a biomimetic nanodrug platform termed MPB-3BP@CM NPs. Comprising microporous Prussian blue (MPB NPs) serving as both photothermal sensitizer carrier 3-bromopyruvate (3BP), these are cloaked genetically...
Spinal fusion is the classic treatment to achieve spinal stability for of disease. Generally, still has combine a certain bone matrix promoting formation desired effect based on surgery, including traditional matrix, such as autologous bone, allografts and xenografts. Nevertheless, some problems existed immunogenic problems, secondary wound, pathogenic transfer so on. Here injectable thermosensitive hydrogel could substitute avoid potential biological scaffold tissue engineering. Once...
Multidrug resistance (MDR) is still a formidable obstacle for the majority of anticancer drugs during chemotherapy. MDR generally divided into pump and nonpump resistances, which significantly simultaneously reduce drug accumulation potency in various cancer cells. In order to concurrently combat two pathways completely overcome MDR, novel siRNA-containing nanomaterial-coated mitochondria complex was developed, can barrier activity loss electrostatic repulsion effectively deliver siRNA this...
Currently, there are approximately 170 million hyperuricemia patients in China. Conventional drug therapy has limited clinical benefits and may induce serious side effects. Enzyme replacement attracted much attention owing to its advantages of strong specificity, small dosage, remarkable curative effect. Uricase is an efficient oxidase, which can oxidize uric acid allantoin hydrogen peroxide, reduce the level. In this study, we used a mild biomimetic method prepare novel uricase horseradish...