A5100440873- Radioactive element chemistry and processing
- Chemical Synthesis and Characterization
- Traditional and Medicinal Uses of Annonaceae
- Luminescence and Fluorescent Materials
- Phytochemistry and Biological Activities
- Synthesis and Catalytic Reactions
- Molecular Sensors and Ion Detection
- Electrochemical Analysis and Applications
- Catalytic C–H Functionalization Methods
- Cancer therapeutics and mechanisms
- Cyclopropane Reaction Mechanisms
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Antimicrobial Resistance in Staphylococcus
- Ginger and Zingiberaceae research
- HER2/EGFR in Cancer Research
- Microbial Natural Products and Biosynthesis
- Peptidase Inhibition and Analysis
- Antibiotic Resistance in Bacteria
- Electrochemical sensors and biosensors
- Extraction and Separation Processes
- Natural product bioactivities and synthesis
- Heavy Metals in Plants
- Monoclonal and Polyclonal Antibodies Research
- Chemical synthesis and alkaloids
Zhuhai People's Hospital
2021-2025
Jinan University
2021-2025
Shenzhen Third People’s Hospital
2025
Southern University of Science and Technology
2025
Yunnan Center for Disease Control And Prevention
2022-2025
Anhui Agricultural University
2025
Ta Solutions (China)
2025
Sichuan University
2013-2024
University of Jinan
2024
Bioinformatics Solutions (Canada)
2024
A novel ratiometric sensor using an electrochemically active metal-organic framework of Mo@MOF-808 and NH2-UiO-66 as response signals was developed to detect tetracycline (TET) in ultratrace quantities. To achieve the dual-response strategy, Mo@MOF-808, with a reduction peak at -1.06 V, NH2-UiO-66, oxidation 0.724 were used signal probes directly. Concretely, single-stranded DNA (ssDNA), complex system (Apt@NH2-UiO-66) aptamer (Apt) sequentially immobilized on electrode. With addition TET,...
A new metal-free, ring-expansion reaction of six-membered N-sulfonylimines with unstable diazomethanes, generated in situ from the N-tosylhydrazones, has been developed. This delivers valuable seven-membered enesulfonamides by a Tiffeneau-Demjanov rearrangement and intramolecular proton transfer tautomerization process. Moreover, this can be carried out one-pot fashion scaled up to gram scale using aryl aldehydes, without need isolate N-tosylhydrazone.
Background Cachexia has a devastating impact on survival and quality of life for many cancer patients contributes to nearly one-third all deaths; also, it is associated with poor responses chemotherapy survival. A better understanding the underlying mechanisms cancer-associated cachexia (CAC), coupled effective therapeutic approaches, will improve management progressive functional impairment in patients. Salidroside, phenylpropanoid glycoside Rhodiola rosea L, been reported possess potential...
A highly efficient, colorimetric and fluorescent probe for recognition of aliphatic primary amines based on a unique cascade chromophore reaction is developed.
Ziyuglycoside I and ziyuglycoside II are important active components of Sanguisorba officinalis L., which have excellent pharmacological effects, such as antioxidant anticancer effects. However, the bioavailability has not been reported. This work aims to establish a UPLC-MS/MS method study pharmacokinetics in rats under different administration routes (intragastric intravenous administration) calculate bioavailability. The concentration rat plasma range 2–2000 ng/mL showed good linear...
Abstract Antibody–drug conjugates (ADCs) take the advantage of monoclonal antibodies to selectively deliver highly potent cytotoxic drugs tumor cells, which have become a powerful measure for cancer treatment in recent years. To develop more effective therapy human epidermal growth factor receptor 2 (HER2)-positive cancer, we explored novel ADCs composed anti-HER2 scFv–HSA fusion with drug DM1. The resulting ADCs, T-SA1–DM1 and T-SA2–DM1 (drug-to-antibody ratio range 3.2–3.5) displayed...
Introduction Methicillin-resistant Staphylococcus aureus (MRSA) sequence type (ST) 45 is a major global MRSA lineage with huge strain diversity and high clinical impact. In Hainan Guangzhou of China, the ST45-MRSA was mainly associated t116. Methods The SA2107 isolated from sputum 5-year-old child pneumonia. whole genome using Illumina (Novaseq 6000) PacBio (Sequel IIe) sequencers, sequences were assembled hybrid assembly. carriage antibiotic resistance genes, virulence mobile genetic...
SARS-CoV-2 infection widely induces antibody response targeting diverse viral proteins, including typical representative N-terminal domain (NTD), receptor-binding (RBD), and S2 subunit of spike. A lot NTD-, RBD-, S2-specific monoclonal antibodies (mAbs) have been isolated from COVID-19 convalescents, some which displaying potent activities to inhibit infection. However, a small portion NTD-specific mAbs elicited by wild-type (WT) primary could facilitate the virus entry into target cells in...
Phytochemical research on the roots of Illigera celebica led to isolation a new aporphine alkaloid, cathafiline B (1), butanolide derivative, illigeralactone A (7), together with six known compounds, namely (2), cassythincine (3), bulbocapine (4), actinodaphine (5), hernangerine (6) and isolincomolide D (8). The chemical composition I. was reported for first time. Compounds 1-3, 6 7 showed no α-glucosidase inhibition activity at 100 μg/mL.
5517 Background: This report presents an update results of the BAT-8006-001-CR trial, which evaluated safety and clinical activity BAT8006, antibody drug conjugate (ADC) consisting a humanized anti-folate receptor alpha (FRα) monoclonal linked to topoisomerase I inhibitor exatecan, in patients with platinum-resistant ovarian cancer (PROC). Methods: Patients epithelial ovarian, fallopian tube, or primary peritoneal received BAT8006 monotherapy every 3 weeks. The adverse events, incidence dose...
Small cell lung cancer (SCLC) is of a highly invasive and metastatic subtype there had not been effective targeted therapies. CD56, surface marker expressed on most SCLC, promising therapeutic target for treatment this aggressive cancer. In study, we generated novel anti-CD56 antibody named promiximab, characterized by high affinity, internalization tumor specificity. Then, the promiximab was conjugated with potent DNA alkylating agent duocarmycin via reduced interchain disulfides to yield...
New Delhi metallo-β-lactamases (NDMs), including at least 28 variants, are a rapidly emerging family of β-lactamases worldwide, with variety infections caused by NDM-positive strains usually associated very poor prognosis and high mortality. NDMs the most prevalent carbapenemases in Escherichia coli (E. coli) especially China. The vast majority blaNDM cases occur on plasmids, which play vital role dissemination blaNDM. To systematically explore relationships between plasmids genes E. obtain...
By attaching hydrophilic OEG on different conjugation sites of SN38, isomeric self-assembling prodrugs were developed and self-assembled into giant nanotubes filamentous assemblies, revealing the critical contribution sites.