A5100317903- Ophthalmology and Visual Impairment Studies
- Acute Ischemic Stroke Management
- Corneal surgery and disorders
- Extracellular vesicles in disease
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Retinal Diseases and Treatments
- Hydrogen's biological and therapeutic effects
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Glaucoma and retinal disorders
- Anesthesia and Pain Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytomegalovirus and herpesvirus research
- Estrogen and related hormone effects
- Spine and Intervertebral Disc Pathology
- Bone fractures and treatments
- Metabolism, Diabetes, and Cancer
- Shoulder Injury and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cultural Heritage Materials Analysis
- Acupuncture Treatment Research Studies
- Shoulder and Clavicle Injuries
- Hip and Femur Fractures
Sichuan University
2022-2025
Lanzhou University
2025
Jiangnan University
2025
Wuxi Fourth People's Hospital
2025
Second Military Medical University
2017-2024
Beijing Normal University
2024
Changhai Hospital
2018-2024
China Medical University
2019-2024
Peking University
2013-2024
First Hospital of Jilin University
2019-2024
Purpose To examine the associations of near work related parameters with spherical equivalent refraction and axial length in Chinese children. Methods A total 1770 grade 7 students mean age 12.7 years were examined cycloplegic autorefraction length. Questions asked regarding time spent outdoors per day, parameters. Results Multivariate models revealed following greater odds myopia: continuous reading (> 45min), ratio [OR], 1.4; 95% confidence interval [CI], 1.1-1.8; close television viewing...
Purpose: To investigate whether time outdoors and a range of other activities are associated with change in spherical equivalent (SE) axial length Chinese children over period 2 years. Methods: A total 1997 aged 12.7 ± 0.5 (10.9–15.6) years the Anyang Childhood Eye Study (ACES) were examined annually (baseline two follow-up visits). Myopia was defined as cycloplegic SE < −0.50 diopters (D). Questionnaires administered to students parents at baseline gauge spent on tasks. We ran mixed linear...
Effective control of non-small-cell lung cancer (NSCLC) remains clinically challenging, especially during advanced stages the disease. This study developed an adoptive T-cell treatment through expression a chimeric antigen receptor (CAR) to target human epidermal growth factor (EGFR) in NSCLC. We optimized non-viral piggyBac transposon system engineer T cells for EGFR-CAR, consisting EGFR scFv, transmembrane domain, and intracellular 4-1BB-CD3ζ signaling domains. The modified CAR exhibited...
Abstract Mesothelin (MSLN) is an attractive antigen for chimeric receptor (CAR) T therapy and the epitope selection within MSLN essential. In this study, we constructed two types of CARs targeting either region I (meso1 CAR, also known as a membrane-distal region) or III (meso3 membrane-proximal using modified piggyBac transposon system. We reported that, compared with meso1 CAR cells, meso3 cells express higher levels CD107α upon activation produce increased interleukin-2, TNF-α, IFN-γ...
Myopia in school-aged children is a public health issue worldwide; consequently, effective interventions to prevent onset and progression are required.To investigate whether SMS text messages parents increase light exposure time outdoors provide myopia control.This randomized clinical trial was conducted China from May 2017 2018, with participants observed for 3 years. Of 528 965 primary Anyang, 3113 were randomly selected. these, 268 grade 2 schoolchildren selected assigned control groups....
We aim to explore whether the effect of oral celecoxib (OC) preoperatively in elderly patients with femoral neck fracture (FNF) receiving surgery on pain control, complications, functional outcomes, and mortality. collected data FNF two hospitals between Jan. 2020 May. 2024. According OC use or not, were divided into group non-OC group. performed propensity score matching (PSM) analysis minimize potential confounding selection bias. observed factors that may influence control by Spearman...
Posttraumatic stress disorder (PTSD) is associated with decreased activity in the dorsolateral prefrontal cortex (DLPFC), brain region that regulates working memory and preparation selection of fear responses.We investigated gene expression profiles DLPFC Brodmann area (BA) 46 postmortem patients (n=6) without PTSD using human mitochondria-focused cDNA microarrays.Our study revealed PTSD-specific fingerprints 800 informative genes across all these 12 BA46 samples, 119 (±>1.25,p<0.05) 42...
Abstract Background Increasing evidence suggests that cancer is a metabolic disease. Here, we investigated the potential role of fructose-1,6-bisphosphatase-2 (FBP2), enzyme catalyses hydrolysis fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate in glucose metabolism, gastric (GC) development. Results Our data indicated FBP2 was downregulated GC tissues (86.2%, 100/116), absent or low expression correlated with poor survival patients ( P = 0.019). Conversely, ectopic...
Currently, there are approximately 170 million hyperuricemia patients in China. Conventional drug therapy has limited clinical benefits and may induce serious side effects. Enzyme replacement attracted much attention owing to its advantages of strong specificity, small dosage, remarkable curative effect. Uricase is an efficient oxidase, which can oxidize uric acid allantoin hydrogen peroxide, reduce the level. In this study, we used a mild biomimetic method prepare novel uricase horseradish...
To investigate the relationship between sleep duration and bedtime with myopia progression axial elongation during a 4-year follow-up in primary school children.This study included 1887 children (aged 7.09 ± 0.41 years) who had cycloplegic refractions data at baseline fourth visit 2209 7.10 for length. All underwent comprehensive ophthalmologic examinations, including refraction ocular biometry, standardized questionnaires, average night-time (h/d) (time to bed). Myopia was defined as...
The high occurrence rate and difficulties in symptom control are listed as the major problems of oral mucosal disease by medical professionals. Following development lesions, microenvironment changes, immunity declines, continuous bacterial stimulation causes wound infection. Traditional antibacterial drugs ineffective for lesions. To overcome this problem, a light-responsive hydrogel containing sustained-release BMSCs was inspired trauma environment cavity, which is different from that on...
Ligamentum flavum (LF) hypertrophy (LFH) has been recognised as one of the key contributors to lumbar spinal stenosis. Currently, no effective methods are available ameliorate this hypertrophy. In study, human umbilical cord mesenchymal stromal cell-derived extracellular vesicles (hUCMSC-EVs) were introduced for first time promising vehicles drug delivery treat LFH. The downregulation miR-146a-5p and miR-221-3p expressions in LF tissues negatively correlated with increased thickness....
The classification of microglial M1/M2 polarization in the acute phase ischemic stroke remains controversial, which has limited further advances neuroprotective strategy. To thoroughly assess phenotypes, we made middle cerebral artery occlusion model mice to simulate pathological processes from normal conditions ischemia and then early reperfusion period. temporal changes gene profiles, cell subtypes, function were comprehensively analyzed using single-cell RNA sequencing. We identified...
Purpose To describe distributions of ocular biometry and their associations with refraction in 7- 14-year-old children urban areas Anyang, central China. Methods A total 2271 grade 1 students aged 7.1 ± 0.4 years 1786 8 13.7 0.5 were measured cycloplegic refraction. parental myopia questionnaire was administered to parents. Results Mean axial length, anterior chamber depth, lens thickness, corneal diameter, radius curvature, length/corneal curvature ratio, spherical equivalent 22.72 0.76 mm,...
Aims To document the difference between non-cycloplegic and cycloplegic refraction explore its associated factors in Chinese young adults. Methods A school-based study including 7971 undergraduates was conducted Anyang, Henan Province, China. Cycloplegia achieved with two drops of 1% cyclopentolate 1 drop Mydrin P (Tropicamide 0.5%, phenylephrine HCl 0.5%) a 5 min interval. Non-cycloplegic refractions were measured by an autorefractor. paired-sample t-test Spearman correlation analysis used...
Abstract Chinese eye exercises have been implemented in China as an intervention for controlling children’s myopia over 50 years. This nested case-control study investigated and their association with development junior middle school children. Outcome measures were the onset progression of a two-year period. Cases defined 1. Myopia (cycloplegic spherical equivalent ≤ −0.5 diopter non-myopic children). 2. (myopia shift ≥1.0 those who myopic at baseline). Two independent investigators assessed...
Abstract Aim To study the role of exosomes in protective effect cerebral ischemic preconditioning (cerebral‐IPC) against I/R injury. Method Mouse models cerebral‐IPC and MCAO/R were established as described previously, their behavioral, pathological, proteomic changes analyzed. Neuro‐2a subjected to OGD/R treated with isolated from plasma sham‐operated mice. The differentially expressed miRNAs between derived (S‐exosomes) preconditioned (IPC‐exosomes) mice identified through miRNA array,...
To investigate the risk factors for myopia progression in primary school children and build prediction models by applying machine learning to longitudinal, cycloplegic autorefraction data. A total of 2740 from grade 1 6 were examined annually over a period 5 years. Myopia was determined as change autorefraction. Questionnaires administered gauge environmental factors. Each year, evaluated built training group then tested an independent hold-out using random forest algorithm. Six variables...
Tissue damage often causes considerable suffering to patients due slow recovery and poor prognosis. The use of electroactive materials deliver biophysical signals plays a key role in regulating tissue regeneration processes. Among these materials, piezoelectric have unique electromechanical conversion capabilities, making them suitable for as cell scaffolds. They can deform emit electrical response external stimuli, thereby proliferation differentiation. In this review, recent advances are...
ABSTRACT Introduction Spiritual well‐being was a critical component of quality life for hemodialysis patients. However, existing research primarily concentrates on the overall level spiritual and associated factors, often neglecting heterogeneity within patients regarding their patterns well‐being. In addition, effect hope levels in remains unclear. This study aimed to examine latent profiles among explore hope. Methods A convenience sampling method employed between July 2023 March 2024...