A5009895190- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disease Mechanisms and Treatments
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Innovations in Medical Education
- Intracerebral and Subarachnoid Hemorrhage Research
- MicroRNA in disease regulation
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Engineering Education and Curriculum Development
- Peripheral Artery Disease Management
- Radiology practices and education
- Corporate Finance and Governance
- Extracellular vesicles in disease
- Financial Markets and Investment Strategies
- Neuroinflammation and Neurodegeneration Mechanisms
- Stroke Rehabilitation and Recovery
- Renal and Vascular Pathologies
- Private Equity and Venture Capital
- Muscle and Compartmental Disorders
- Ideological and Political Education
- Higher Education and Teaching Methods
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Second Military Medical University
2010-2023
Changhai Hospital
2010-2023
Qiqihar Medical University
2020-2022
Sichuan University
2011-2020
West China Hospital of Sichuan University
2011-2020
First Affiliated Hospital of Harbin Medical University
2005-2018
Harbin Medical University
2005-2018
University of London
2010-2017
SOAS University of London
2010-2017
Universidad de Londres
2015
Background Nuclear factor-κB (NF-κB) is a central transcriptional factor and pleiotropic regulator of many genes involved in acute lung injury. Andrographolide found the plant Andrographis paniculata widely used Traditional Chinese Medicine, exhibiting potently anti-inflammatory property by inhibiting NF-κB activity. The purpose our investigation was designed to reveal effect andrographolide on various aspects LPS induced inflammation vivo vitro. Methods Results In vivo, BALB/C mice were...
Moyamoya disease (MMD) is a cerebrovascular characterized by progressive stenosis of the intracranial internal carotid arteries and their proximal branches. However, etiology this rare remains unknown. Serum microRNA (miRNA) profiles have been screened to identify novel biomarkers prognostic values. Here, we identified serum miRNAs that might play an important role in pathogenesis MMD. A genome-wide miRNA array analysis two pooled samples from patients with MMD controls revealed 94...
Indices for the diagnosis of hyperacute cerebral infarction (HACI) and prediction prognosis are essential timely appropriate management. MicroRNAs (miRNAs) that regulate gene expression following stroke have potential use as prognostic markers HACI. Here, we explored whether concentrations circulating miRNAs correlate with clinical outcomes thus form a system stratification. Plasma samples from patients HACI (n = 7) age-matched healthy volunteers (HVT, n 4) were screened by microarray to...
Abstract Aim To study the role of exosomes in protective effect cerebral ischemic preconditioning (cerebral‐IPC) against I/R injury. Method Mouse models cerebral‐IPC and MCAO/R were established as described previously, their behavioral, pathological, proteomic changes analyzed. Neuro‐2a subjected to OGD/R treated with isolated from plasma sham‐operated mice. The differentially expressed miRNAs between derived (S‐exosomes) preconditioned (IPC‐exosomes) mice identified through miRNA array,...
The added value of intravenous alteplase in reperfusing ischemic brain tissue patients undergoing endovascular treatment and directly presented to an treatment-capable hospital is uncertain. We conducted this post hoc analysis a randomized trial (DIRECT-MT [Direct Intraarterial Thrombectomy Order Revascularize Acute Ischemic Stroke Patients With Large Vessel Occlusion Efficiently Chinese Tertiary Hospitals: A Multicenter Randomized Clinical Trial]) explore the association alteplase, early...
The classification of microglial M1/M2 polarization in the acute phase ischemic stroke remains controversial, which has limited further advances neuroprotective strategy. To thoroughly assess phenotypes, we made middle cerebral artery occlusion model mice to simulate pathological processes from normal conditions ischemia and then early reperfusion period. temporal changes gene profiles, cell subtypes, function were comprehensively analyzed using single-cell RNA sequencing. We identified...
Rationale Intravenous thrombolysis combined with mechanical thrombectomy (MT) has been proven safe and clinical effective in patients acute ischemic stroke of anterior circulation large vessel occlusion. However, despite reperfusion, a considerable proportion do not recover. Incidence symptomatic intracerebral hemorrhage was similar between treated the combination intravenous MT, as compared to alone, suggesting that this complication should be attributed pre-treatment thrombolysis....
Mesenchymal stem cells (MSCs)-derived exosomes (Exo) are beneficial in the use of brain damages. Restrictively, mechanism Exo expressing miR-124-3p hypoxic-ischemic damage (HIBD) is not completely comprehended. Thereupon, this work was put forward to reveal action bone marrow MSCs-derived (BMSCs-Exo) illness. BMSCs were isolated and transfected with agomir. Then, BMSCs-Exo extracted identified. The newborn HIBD rats injected miR-124-3p-modified or tumor necrosis factor receptor associated 6...
Background Recent evidence suggests that presence of an intracranial arterial thrombus with a hyperdense artery sign (HAS) at noncontrast CT (NCCT) is associated better response to intravenous alteplase. Patients HAS may benefit more from combined alteplase and endovascular treatment (EVT). Purpose To investigate whether NCCT modifies the effect adding on clinical outcome in patients acute large-vessel occlusion undergoing EVT. Materials Methods This study secondary analysis prospective...
Background and Purpose: Recent trials showed thrombectomy alone was comparable to bridging therapy in patients with anterior circulation large vessel occlusion eligible for both intravenous alteplase endovascular thrombectomy. We performed this study examine whether site modifies the effect of before Methods: This is a prespecified subgroup analysis randomized trial evaluating risk benefit (DIRECT-MT [Direct Intra-Arterial Thrombectomy Order Revascularize AIS Patients With Large Vessel...
Astrocyte plays important roles in the pathogenesis of ischemic stroke and reperfusion injury. They intensively participate energy metabolism brain, while their heterogeneity function after remain controversial. By employing single-cell sequencing mice cortex at 12 h transient middle cerebral artery occlusion (tMCAO) comparing with similar published datasets 24h tMCAO, we uncover cellular phenotypes dynamic change astrocytes acute phase stroke. In this study, separately identified 3 major...
Acute fatty liver of pregnancy (AFLP) is an uncommon but clinically severe hepatopathy, and reactive oxygen species (ROS)-mediated mitochondrial apoptosis may be its key pathogenesis. Traditional therapy inadequate for patients with conditions so the application plasma exchange (PE) has been attempted. The present study aims to determine whether or not PE can lessen injuries hepatocytes by ameliorating ROS functions. Thirteen AFLP were included in experimental group, while fifteen made up...
Abstract Rhabdomyolysis ( RM ) and subsequent myoglobin Mb deposition can lead to acute kidney injury. Continuous venovenous hemofiltration CVVH remove , but direct renal protection is unclear. We hypothesized that improve mitochondrial dysfunction in its early stage. Twenty‐four mongrel dogs were randomly divided into four groups: (A) control; (B) model; (C) model + (50 mL /kg/h); (D) (30 /kg/h). was induced by glycerol via intramuscular injection. The closely monitored for urine flow...
Abstract Background Patients with acute pancreatitis usually exhibit dyslipidemia and oxidative stress. However, the significance of high-density lipoprotein cholesterol (HDL-C) level, low-density (LDL-C) level HDL-C/LDL-C ratio (H/L ratio) as markers for disease progression remain unknown. Aim The aim this study was to evaluate role HDL-C levels, LDL-C levels H/L in patients admitted intensive cate unit pancreatitis. Methods This retrospective conducted at a tertiary critical care center...
Since the global standards for postgraduate medical education (PGME) were published in January 2003, they have gained worldwide attention. The current state of residency training programs medical-school-affiliated hospitals throughout China was assessed this study.Based on internationally recognized PGME, residents undergoing at that time and relevant instructors management personnel from 15 recruited surveyed regarding programs. A total 938 questionnaire surveys distributed between June 30,...