A5101534953- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Cell death mechanisms and regulation
- Bone Metabolism and Diseases
- Neurological Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Seaweed-derived Bioactive Compounds
- Cell Adhesion Molecules Research
- Heme Oxygenase-1 and Carbon Monoxide
- Liver physiology and pathology
- Anesthesia and Neurotoxicity Research
- Tendon Structure and Treatment
- Allelopathy and phytotoxic interactions
- Phagocytosis and Immune Regulation
- Phase Change Materials Research
- Quinazolinone synthesis and applications
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
Xuzhou Medical College
2024-2025
Xuzhou No.1 People's Hospital
2025
Yueyang Hospital
2021-2024
Shanghai University of Traditional Chinese Medicine
2021-2024
Affiliated Hospital of Xuzhou Medical College
2024
Second Military Medical University
2014-2022
Changhai Hospital
2019-2022
Chengdu Third People's Hospital
2021
Southwest Jiaotong University
2021
Xinjiang Production and Construction Corps
2021
Abstract To investigate whether microRNA‐24 (miR‐24) targeting C‐myc affects chondrocytes of rats with osteoarthritis (OA) via the MAPK signaling pathway. Thirty were assigned as a sham group and an OA (established rat models by cutting anterior cruciate ligaments removing 1/3 medial meniscus). TUNEL staining immunohistochemistry conducted for cell apoptosis index (AI) positive expression rate protein. Enzyme‐linked immuno sorbent assay (ELISA) was carried out serum level IL‐1β TNF‐α....
Abstract To effectively address underlying issues and enhance the healing process of hard-to-treat soft tissue defects, innovative therapeutic approaches are required. One promising strategy involves incorporation bioactive substances into biodegradable scaffolds to facilitate synergistic regeneration, particularly in vascular regeneration. In this study, we introduce a composite hydrogel design that mimics extracellular matrix by covalently combining gelatin hyaluronic acid (HA), with...
Diabetic foot ulcer (DFU) is a kind of common and disabling complications Diabetes Mellitus (DM). Emerging studies have demonstrated that tendon fibroblasts play crucial role in remodeling phase wound healing. However, little known about the mechanism underlying high glucose (HG)-induced decrease viability. In present study rat models DFU were established, collagen deposition, autophagy activation cell apoptosis tissues assessed using hematoxylin-eosin (HE) staining, immunohistochemistry...
Exposure to air pollutants cause exacerbation of asthma, but the experimental evidence and mechanisms still need be collected addressed.
Background: Dehydrocostus lactone (DEH), one of the sesquiterpene lactones, has shown extensive pharmaceutical activities, including anti-cancer activity. However, its effects on human esophageal squamous cell carcinoma (ESCC) cells are still unknown. Objective: To investigate effect DEH ESCC and underling molecular mechanisms. Method: The proliferation was tested using CCK-8 colony formation assay. Apoptosis analyzed by flow cytometry, hoechst staining caspase-3 activity Cell cycle...
2-Tridecanone, a plant allelochemical present in large range of tomato species (Lycopersicon hirsutum f. glabratum), can induce the expression Helicoverpa armigera transferrin (HaTrf), which is necessary for insect growth and development. To gain further insight into mechanism HaTrf response to 2-tridecanone, we measured iron H2O2 levels hemolymph during exposure 2-tridecanone then explored effect downregulation H. fat body cell line exposed 2-tridecanone. We found that reduction via RNA...
Abstract Integrin β1 subunit and its downstream molecules, such as integrin‐linked kinase focal adhesion kinase, are imperative for promotion of cell proliferation, survival anti‐apoptosis in cardiomyocytes by activation their pro‐survival signalling the phosphorylated extracellular signal‐regulated kinase1/2 (p‐ERK1/2). As a component integrin pathway, C3G (Crk‐SH3 domain guanine nucleotide exchange factor) protein may be involved proliferation H9C2 cardiomyocytes. Rat ‐ derived were...
<title>Abstract</title> Objective Osteoporosis is a systemic disease with high morbidity and significant adverse effects. Increasing evidence supports the close relationship between oxidative stress osteoporosis, suggesting that treatment antioxidants may be viable approach. This study evaluated antioxidant properties of dichotomitin (DH) its potential protective effects against osteoporosis. Methods SD rats were divided into three groups (n = 4 per group): Sham, OVX, OVX + DH (5mg/kg,...
The current research hot spot in the field of autophagic flux is to explain and alleviate disease from perspective autophagy. A highly sophisticated, sensitive, quantifiable comprehensive method required accurately determine dynamic process flux. There are very few methods neuroscience that specifically examine Therefore, primary cortical neurons were divided into oxygen glucose deprivation/reperfusion (OGD/R) (group A) OGD/R plus bafilomycin A1 (BafA1) B) groups. ① Transfection LC3 gene...
OBJECTIVE To study the effects of dihydroartemisinin (DHA) on radiation sensitivity Raji cells, and explore its mechanisms. METHODS CCK8 was used to determine effect DHA cell viability cells; apoptosis, intracellular reactive oxygen speies(ROS) mitochondrial membrane potential cells were detected by flow cytometry; protein expressions kinase B(AKT), phospho-rylated-protein B(p-AKT), Bcl-2 Bax determined Western blot. RESULTS The randomly divided into four groups:control group, DHA(5μmol/L...