A5100544028- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- PI3K/AKT/mTOR signaling in cancer
- Estrogen and related hormone effects
- Lung Cancer Research Studies
- Renal and related cancers
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Kruppel-like factors research
- RNA Research and Splicing
- Web Data Mining and Analysis
- Semantic Web and Ontologies
- Recommender Systems and Techniques
- HER2/EGFR in Cancer Research
LinkedIn (United States)
2024
Henan University Huaihe Hospital and Huaihe Clinical Institute
2017-2020
Long non-coding RNAs (lncRNAs) have been identified as critical regulators in the development of atherosclerosis (AS). Here, we focused on discussing roles and molecular mechanisms lncRNA H19 vascular smooth muscle cells (VSMCs) progression.RT-qPCR assay was used to detect expression patterns miR-148b clinical samples cells. Cell proliferative ability evaluated by CCK-8 colony formation assays. apoptotic capacity assessed cell percentage caspase-3 activity. Bioinformatics analysis,...
The carcinogenesis and progression of cervical cancer is a complex process in which numerous microRNAs are involved. purpose this study to investigate the role miR-125a-5p cancer.RT-qPCR was used detect expression GALNT7 tissues cell lines. Then, mimic, inhibitor, siRNA, or/and pcDNA-GALNT7 were respectively transfected into HeLa Caski cells, Cell Counting kit-8 assay, Transwell assay flow cytometry analysis observe proliferation, invasion apoptosis. Subsequently, luciferase reporter gene...
Circular RNAs (circRNAs) are a novel class of endogenous noncoding and have been shown to play important roles in variety physiological processes. Recently, dysregulation circRNAs has identified many types cancers. In this study, we analyzed the expression profile biological functions circMTO1 ovarian cancer. We demonstrated that was downregulated cancer tissues cell lines. Upregulation inhibited proliferation invasion cells while downregulation promoted these Mechanistically, showed sponged...
We present LiRank, a large-scale ranking framework at LinkedIn that brings to production state-of-the-art modeling architectures and optimization methods. unveil several improvements, including Residual DCN, which adds attention residual connections the famous DCNv2 architecture. share insights into combining tuning SOTA create unified model, Dense Gating, Transformers DCN. also propose novel techniques for calibration describe how we productionalized deep learning based explore/exploit
<p>Supplementary Figure 1. Representative images of metastases found in the liver (left panel) and peritoneal wall (right Pten loxp/loxp Lkb1loxp/loxp female mice bearing Lkb1-deficient endometrial tumors. Supplementary 2. Genotyping tumors for recombined alleles (A) Lkb1 (B). Genomic DNAs from (lanes 1–4) or mouse tail 5) were extracted. PCR analysis was done as previously described (1, 2). 3. immunohistochemical staining (B) proteins counterstained with hematoxylin. Bars, 25μM....
<p>Supplementary information - PDF file 2943K, Supplementary Figure 1: Dox-induced iPIK3.iCre transgenic mouse model of PIK3CA mutant breast cancer. 2: Loss ErbB3 delays mammary gland hyperplasia at 12 weeks. 3: IVIS Bioluminescent imaging. 4: Histology PIK3CA-induced tumors remains diverse when is lost. 5: Mutant PI3K binds to IRS-1, Gab1 and other tyrosinephosphorylated proteins in treated with lapatinib and/or imatinib. 6: Combination BYL719 tumor growth without causing liver...
<p>Supplementary information - PDF file 2943K, Supplementary Figure 1: Dox-induced iPIK3.iCre transgenic mouse model of PIK3CA mutant breast cancer. 2: Loss ErbB3 delays mammary gland hyperplasia at 12 weeks. 3: IVIS Bioluminescent imaging. 4: Histology PIK3CA-induced tumors remains diverse when is lost. 5: Mutant PI3K binds to IRS-1, Gab1 and other tyrosinephosphorylated proteins in treated with lapatinib and/or imatinib. 6: Combination BYL719 tumor growth without causing liver...
<p>Supplementary Figure 1. Representative images of metastases found in the liver (left panel) and peritoneal wall (right Pten loxp/loxp Lkb1loxp/loxp female mice bearing Lkb1-deficient endometrial tumors. Supplementary 2. Genotyping tumors for recombined alleles (A) Lkb1 (B). Genomic DNAs from (lanes 1–4) or mouse tail 5) were extracted. PCR analysis was done as previously described (1, 2). 3. immunohistochemical staining (B) proteins counterstained with hematoxylin. Bars, 25μM....
<div>Abstract<p>Signals from the tumor suppressors PTEN and LKB1 converge on mTOR to negatively regulate its function in cancer cells. Notably, both of these are attenuated a significant fraction human endometrial tumors. In this study, we generated genetic mouse model driven by concomitant loss gain pathophysiological insight into disease. Dual Pten Lkb1 epithelium led rapid development advanced endometrioid tumors with 100% penetrance short host survival. The displayed...
<div>Abstract<p>Mutations in <i>PIK3CA</i>, the gene encoding p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), have been shown to transform mammary epithelial cells (MEC). Studies suggest this transforming activity requires binding mutant via p85 phosphorylated YXXM motifs activated receptor tyrosine kinases (RTK) or adaptors. Using transgenic mice, we examined if ErbB3, a potent activator PI3K, is required for <i>PIK3CA</i>-mediated...
<div>Abstract<p>Mutations in <i>PIK3CA</i>, the gene encoding p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), have been shown to transform mammary epithelial cells (MEC). Studies suggest this transforming activity requires binding mutant via p85 phosphorylated YXXM motifs activated receptor tyrosine kinases (RTK) or adaptors. Using transgenic mice, we examined if ErbB3, a potent activator PI3K, is required for <i>PIK3CA</i>-mediated...
<div>Abstract<p>Signals from the tumor suppressors PTEN and LKB1 converge on mTOR to negatively regulate its function in cancer cells. Notably, both of these are attenuated a significant fraction human endometrial tumors. In this study, we generated genetic mouse model driven by concomitant loss gain pathophysiological insight into disease. Dual Pten Lkb1 epithelium led rapid development advanced endometrioid tumors with 100% penetrance short host survival. The displayed...