A5089300103- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Cancer-related molecular mechanisms research
- Gastrointestinal motility and disorders
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- Drug-Induced Hepatotoxicity and Protection
- Diet and metabolism studies
- Immune Response and Inflammation
- Allergic Rhinitis and Sensitization
- Hippo pathway signaling and YAP/TAZ
- Cancer-related gene regulation
- Mycobacterium research and diagnosis
- Contact Dermatitis and Allergies
- Complementary and Alternative Medicine Studies
- Immune Cell Function and Interaction
- Apelin-related biomedical research
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
Yangzhou University
2024
Central South University
2024
Tianjin Third Central Hospital
2024
Tianjin Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2014-2023
First Affiliated Hospital of Zhengzhou University
2023
Southern Medical University
2022
Nanfang Hospital
2022
Affiliated Hospital of Guizhou Medical University
2018-2022
Guiyang Medical University
2018-2022
Cancer stem cells (CSCs) are the key factor in determining cancer recurrence, metastasis, chemoresistance and patient prognosis hepatocellular carcinoma (HCC).The role of miR-5188 stemness has never been documented.In this study, we investigated clinical biological roles HCC.Methods: MiRNA expression HCC was analyzed by bioinformatics analysis situ hybridization.The effect demonstrated both vitro vivo studies through ectopic miR-5188.The target gene molecular pathway were characterized using...
Zhao L. Zhou Y, Xu Sun Li L, Chen W. Effect of non-surgical periodontal therapy on the levels Th17/Th1/Th2 cytokines and their transcription factors in Chinese chronic periodontitis patients. J Clin Periodontol 2011; doi: 10.1111/j.1600-051X.2011.01712.x. Abstract Aim: A new subset CD4+ T cells, Th17, has been recently discovered independent from Th1/Th2 paradigm. The aim this study was to investigate effects expression factors, Th17 cell vibration Materials methods: (IL-17,...
Purpose:The incidence of malignant melanoma (MM) has risen over the past three decades, and despite advancements in treatment, there is still a need to improve treatment modalities.This study developed promising strategy for tumor-targeted co-delivery Dacarbazine (DTIC) miRNA 34a-loaded PHRD micelles (Co-PHRD) combination MM.Methods: To construct dual drug-loaded delivery system Co-PHRD, poly (L-arginine)-poly (L-histidine)-polylactic acid (PLA) was employed as building block.In this system,...
The critical long non‑coding RNAs (lncRNAs) involved in the carcinogenesis and progression of malignant melanoma (MM) have not been fully investigated. In present study, it was identified that lncRNA activated by transforming growth factor‑β (lncRNA‑ATB) upregulated MM tissues cells compared with benign nevus human melanocytes, via comparative screening from Gene Expression Omnibus datasets reverse transcription‑quantitative polymerase chain reaction analysis. Furthermore, lncRNA‑ATB...
Accumulating evidence indicates a critical role for T cells and relevant cytokines in the pathogenesis of systemic lupus erythematosus (SLE). However, specific contribution together with related circulating disease organ involvement is still not clear. In current study, we investigated molecule expressions cytokine levels blood samples from 49 SLE patients 22 healthy control subjects. The expression HLA-DR costimulatory molecules on was evaluated by flow cytometry. Concentrations serum...
Transient receptor potential ankyrin 1 (TRPA1), a membrane protein ion channel, is known to mediate itch and pain in skin. The function of TRPA1, however, psoriasiform dermatitis (PsD) uncertain. Herein, we found that expression TRPA1 highly up-regulated human psoriatic lesional To study the role PsD, assessed Psoriasis Severity Index (PSI) scores, transepidermal water loss (TEWL), skin thickness pathology, examined dermal inflammatory infiltrates, Th17-related genes itch-related c57BL/6 as...
IL-22 is known to mediate inflammation in psoriasis, while binding protein (IL-22BP) binds suppress signaling. However, the function of regulating apoptosis psoriasis remains poorly understood. In this study, we found that IL-22/IL-22R1 lesional skin and serum from psoriatic patients were highly upregulated compared with healthy controls, IL-22BP was not changed. Correlations between levels thickness lesions suggested might positively regulate abnormal hyperplasia psoriasis. Apoptotic...
Previous studies have reported the pathogenic role of C-reactive protein (CRP) during diabetic kidney disease (DKD) in human CRP transgenic and Crp-/- mice. However, because humans mice inverse acute phase expression patterns serum amyloid P component, this could lead to inaccurate evaluation function with above-mentioned mouse. But different from mice, rats same pattern as human, which might avoid problem be a better choice for studies. To dispel doubt accurately define nephropathy, we...
The link between Apelin (APL)/APL receptor (APJ) and Jagged (JAG)/Notch signaling pathways in colorectal cancer (CRC) has been poorly investigated. APL/APJ system, a potent angiogenic factor, is up-regulated variety of cancers. It contributes to tumor angiogenesis, correlates with progression malignancy. JAG/Notch also progression, proliferation metastasis multiple cancers, including CRC. Here we tested the hypothesis that system promotes CRC by up-regulating Notch3, thus allowing further...
Abstract Atopic dermatitis ( AD ) and psoriasis (Pso) are two common inflammatory skin diseases which symptomatically characterized by pruritus to variable degrees. Whereas is nearly always associated with pruritus, only 50%‐70% of patients Pso suffer from itching. Within the last decade, development biologic agents targeting specific cytokines or cytokine receptors has led tremendous progress in suppressing inflammation (and thus improving quality life) these diseases. While would generally...
Background and Aims NAFLD has become the most common liver disease worldwide but lacks a well‐established pharmacological therapy. Here, we aimed to investigate role of an E3 ligase SH3 domain‐containing ring finger 2 (SH3RF2) in further explore underlying mechanisms. Methods Results In this study, found that SH3RF2 was suppressed setting across mice, monkeys, clinical individuals. Based on genetic interruption model, demonstrated hepatocyte deficiency markedly deteriorates lipid...
Loganin, a monoterpene iridoid glycoside derived from Cornus officinalis Sieb. Et Zucc, has been reported to have anti-inflammatory and antioxidant activity. Nevertheless, the potential role molecular mechanism of loganin in cerebral ischemia-reperfusion (I/R) injury are not well-understood. The purpose study was explore functional inflammation, oxidative stress, apoptosis I/R rats MATERIALS AND METHODS: Following middle artery occlusion (MCAO), 80 mg/kg intragastrically administered for 7...
Long intergenic noncoding RNA 00961 (Linc00961) has been identified as a tumor suppressor in various types of cancer. However, the critical roles Linc00961 carcinogenesis and progression skin melanoma (SM) are yet to be fully elucidated. The present study revealed via reverse transcription‑quantitative PCR analysis that was downregulated tissues patients with SM compared benign nevi, A375, A2058 SK‑MEL‑28 cell lines human melanocytes. Furthermore, overexpression inhibited proliferation,...
Plaque psoriasis is a chronic inflammatory skin disease that affects substantial proportion of the world population. This disorder characterized by scaly, thick skin, intense ongoing itch, and itch from light touch (such as clothing contacting called “alloknesis”). Imiquimod topical treatment for basal cell carcinomas warts has been used to create mouse model plaque psoriasis. Imiquimod-treated male, but not female, wildtype B6 mice showed significant increases in spontaneous scratching,...
The invasion-metastasis cascade is one of the most important factors relating to poor survival and prognosis malignant melanoma (MM) patients. Long non-coding RNA lymph node metastasis associated transcript 1 (LNMAT1) a key regulator in multiple cancer types, but roles underlying mechanisms LNMAT1 MM remain unclear. In present study, we aimed investigate expression function MM. Here, found that was upregulated tissues cells, its levels were further enhanced patients with metastatic cells....
Long non‑coding RNA homeobox A11‑antisense (HOXA11‑AS) has been implicated in cisplatin (DDP) resistance multiple types of cancer. The purpose the present study was to investigate role HOXA11‑AS DDP‑resistant nasopharyngeal carcinoma (NPC) cells. expression levels were examined using reverse transcription‑quantitative PCR. Cell viability measured a Counting Kit‑8 assay, and TUNEL assay utilized assess cell apoptosis. apoptosis‑related factors (Bax Bcl‑2) detected by western blot analysis....