A5086524896- Animal Genetics and Reproduction
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Robotic Locomotion and Control
- Hepatitis C virus research
- interferon and immune responses
- Viral Infections and Immunology Research
- Prosthetics and Rehabilitation Robotics
- Heme Oxygenase-1 and Carbon Monoxide
- Lipid metabolism and biosynthesis
- Minimally Invasive Surgical Techniques
- Atmospheric Ozone and Climate
- Endoplasmic Reticulum Stress and Disease
- Fatty Acid Research and Health
- RNA modifications and cancer
- Polysaccharides and Plant Cell Walls
- Signaling Pathways in Disease
- Atmospheric chemistry and aerosols
- Surgical Simulation and Training
- Nuclear Receptors and Signaling
- Spinal Fractures and Fixation Techniques
- Soft Robotics and Applications
- Nuclear Engineering Thermal-Hydraulics
Huanggang Central Hospital
2021-2025
China Academy of Space Technology
2021-2025
University of Science and Technology of China
2023-2025
Huazhong Agricultural University
2025
Henan Institute of Science and Technology
2024
Shanghai Jiao Tong University
2019-2024
Xi'an Jiaotong University
2022-2024
Yangtze University
2024
North China Electric Power University
2015-2024
Hebei Medical University
2024
Polar auxin transport, mediated by influx and efflux transporters, controls many aspects of plant growth development. The carriers in Arabidopsis have been shown to control lateral root development gravitropism, but little is known about these proteins rice. This paper reports on the functional characterization OsAUX1. Three OsAUX1 T-DNA insertion mutants RNAi knockdown transgenic plants reduced initiation compared with wild-type (WT) plants. overexpression exhibited increased was highly...
NAFLD is the most prevalent chronic liver disease without any Food and Drug Administration-approved pharmacological intervention in clinic. Fatty acid synthase (FASN) one of attractive targets for treatment because its robust rate-limiting capacity to control hepatic de novo lipogenesis. However, regulatory mechanisms FASN potential therapeutic strategies targeting remain largely unknown.Through a systematic interactomics analysis FASN-complex proteins, we screened identified sorting nexin 8...
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic worldwide. The advanced stage of NAFLD, non-alcoholic steatohepatitis (NASH), been recognized as a leading cause end-stage injury for which there are no FDA-approved therapeutic options. Glutathione S-transferase Mu 2 (GSTM2) is phase II detoxification enzyme. However, roles GSTM2 in NASH have not elucidated.Multiple RNA-seq analyses were used to identify hepatic expression NASH. In vitro and vivo gain- or...
Background: With the development of industrialization in human society, ambient pollutants are becoming more harmful to health. Epidemiological and toxicological studies indicate that a close relationship exists between particulate matter with diameter ≤2.5 µm (PM 2.5 ) neurodegenerative diseases such as Alzheimer's disease (AD) Parkinson's (PD). To further confirm relationship, we focus on possible relevant mechanisms oxidative stress neuroinflammation underlying association PM review....
Background and Aims NAFLD is the most prevalent chronic liver disease worldwide, but no effective pharmacological therapeutics are available for clinical use. NASH more severe stage of NAFLD. During this progress, dysregulation endoplasmic reticulum (ER)–related pathways proteins one predominant hallmarks. We aimed to reveal role ring finger protein 5 (RNF5), an ER-localized E3 ubiquitin-protein ligase, in explore its underlying mechanism. Approach Results first inspected expression level...
Hepatic ischemia/reperfusion (I/R) injury, a common clinical problem that occurs during liver surgical procedures, causes large proportion of early graft failure and organ rejection cases. The identification key regulators hepatic I/R injury may provide potential strategies to clinically improve the prognosis surgery. Here, we aimed identify role tumor necrosis factor alpha-induced protein 3-interacting 3 (TNIP3) in further reveal its immanent mechanisms.In present study, found hepatocyte...
Compared to metal packaging and ceramic packaging, plastic encapsulated microcircuits (PEMs) have the advantages of light weight low cost. However, due their non-airtightness, they are prone delamination, corrosion, other failures in humid hot environments. In engineering practice, unbiased highly accelerated stress test (UHAST) without bias voltage is commonly used evaluate moisture heat resistance PEMs, but it cannot fully excite potential defects PEMs. Therefore, necessary consider biased...
ABSTRACT Glioblastoma (GBM) is the most common malignant primary brain tumor, with a mean survival of less than 2 years. Unique structures and microenvironment, including blood−brain barriers, put great challenges on clinical drug development. Sophoricoside (Sop), an isoflavone glycoside isolated from seeds Sophora japonica L., one active constituents traditional Chinese medicine found to inhibit bioactivity cytokines (e.g., interleukin‐5) inflammatory responses, as well attenuate glucose...
Inflammatory bowel disease (IBD) remains an incurable condition, often accompanied by high rates of anxiety and depression, further diminishing the quality life patients. Endogenous gasotransmitters, such as carbon monoxide (CO) hydrogen sulfide (H2S), exhibit potent anti‐inflammatory immunomodulatory effects. However, their therapeutic application is limited challenges in targeted delivery to affected tissues. Here, we propose a novel strategy for gut CO/H2S through engineering Escherichia...
Inflammatory bowel disease (IBD) remains an incurable condition, often accompanied by high rates of anxiety and depression, further diminishing the quality life patients. Endogenous gasotransmitters, such as carbon monoxide (CO) hydrogen sulfide (H2S), exhibit potent anti‐inflammatory immunomodulatory effects. However, their therapeutic application is limited challenges in targeted delivery to affected tissues. Here, we propose a novel strategy for gut CO/H2S through engineering Escherichia...
Abstract Background and Aims Ischemia‐reperfusion (I/R) injury is an inevitable complication of liver transplantation (LT) compromises its prognosis. Glycosyltransferases have been recognized as promising targets for disease therapy, but their roles remain open study in hepatic I/R (HIR) injury. Here, we aim to demonstrate the exact function molecular mechanism a glycosyltransferase, N‐acetylgalactosaminyltransferase‐4 (GALNT4), HIR Approach Results By RNA‐sequencing data‐based correlation...
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic worldwide, without any Food and Drug Administration-approved pharmacological intervention in clinic. Trim38, as an important member of TRIM (tripartite motif-containing) family, was largely reported to be involved regulation innate immune inflammatory responses. However, functional roles TRIM38 NAFLD remain unknown. Here, expression first detected samples both mice model patients diagnosed with NAFLD. We found...
Abstract Pathological cardiac hypertrophy is one of the major risk factors heart failure and other cardiovascular diseases. However, mechanisms underlying pathological remain largely unknown. Here, we identified first evidence that TNFAIP3 interacting protein 3 (TNIP3) was a negative regulator hypertrophy. We observed significant upregulation TNIP3 in mouse hearts subjected to transverse aortic constriction (TAC) surgery primary neonatal rat cardiomyocytes stimulated by phenylephrine (PE)....
Abstract Electrocatalysts based on high‐valent indium are promising for formate production via CO 2 electroreduction. However, reconstruction often occurs during the reaction progress, resulting in a decline catalytic performance. Here, composite of In O 3 /In S is developed, and its performance exceeds that either individual phase, particularly stability. Analysis morphology, valence state, situ Raman spectroscopy reveals well preserved reaction. Theoretical calculations suggest desorption...
Background and Aims Although the prevalence of NAFLD has risen dramatically to 25% adult population worldwide, there are as yet no approved pharmacological interventions for disease because uncertainty about underlying molecular mechanisms. It is known that mitochondrial dysfunction an important factor in development NAFLD. Mitochondrial antiviral signaling protein (MAVS) a critical adaptor host defenses against viral infection. However, role MAVS metabolism during progression remains...
To compare the clinical and radiographic outcomes of oblique lateral lumbar interbody fusion minimally invasive transforaminal in patients with grade-1 L4/5 degenerative spondylolisthesis.Based on inclusion exclusion criteria, comparative analysis included consecutive spondylolisthesis who underwent LIF (OLIF, n = 36) or (MI-TLIF, 45) at Department Spine Surgery, Beijing Jishuitan Hospital from January 2016 to August 2017. Patient satisfaction Japanese Orthopaedic Association score, visual...
Xylogen, a chimeric arabinogalactan protein containing non-specific lipid transfer domain, can promote xylem cell differentiation. No comprehensive study has been carried out on the XYLP gene family in rice. As first step research this and as useful strategy general, genome-wide analysis of OsXYLP is thus needed.In study, we identified 21 genes from rice genome comprehensively analyzed their structures, phylogenetic relationships, chromosomal locations, duplication status. Our results...
Background and Aims NAFLD has become the most common liver disease worldwide but lacks a well‐established pharmacological therapy. Here, we aimed to investigate role of an E3 ligase SH3 domain‐containing ring finger 2 (SH3RF2) in further explore underlying mechanisms. Methods Results In this study, found that SH3RF2 was suppressed setting across mice, monkeys, clinical individuals. Based on genetic interruption model, demonstrated hepatocyte deficiency markedly deteriorates lipid...