In this feature article we summarize the recent developments of stimuli responsive gels based on low molecular weight gelators (LMWGs) for which gel-sol transitions can be triggered by other besides heating. These include to redox reactions and light irradiations. Chemoresponsive are also introduced, including those induced with neutral molecules gel strength is improved following addition molecules. Perspectives such discussed regard their potential applications remaining challenging issues.

Abstract A dendron‐substituted tetraphenylethene low molecular weight gelator (LMWG)compound, LMWG 1, is designed and investigated. Gelation‐induced fluorescence enhancement observed for the gel based on 1 its can be reversibly tuned by varying temperature of ensemble. The photoinduced energy‐transfer occur between PI 2 (perylene diimide) in phase, but it cannot corresponding solution. emission color from cyan, yellow, to red concentration . By taking advantage photochromic transformation...

Green nanocomposites containing biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and cellulose nanocrystals/silver (CNC-Ag) nanohybrids were synthesized their properties investigated. It was found that homogeneously dispersed CNC-Ag could act as bifunctional reinforcements to improve the thermal, mechanical antibacterial of PHBV. Compared pristine PHBV, tensile strength maximum decomposition temperature (Tmax) nanocomposite with 10 wt% enhanced by 140% 24.2 °C, respectively....

Lipid droplets (LDs) are intracellular storage sites for triacylglyerols (TAGs) and steryl esters, play essential roles in energy metabolism membrane biosynthesis. Adipose triglyceride lipase (ATGL) is the key enzyme TAG hydrolysis (lipolysis) adipocytes LD degradation nonadipocyte cells. Lipase activity of ATGL vivo largely depends on its C-terminal sequence as well coactivation by CGI-58. Here we demonstrate that hydrophobic domain required targeting CGI-58-independent degradation....

BACKGROUND AND PURPOSE The class III PI3K inhibitor, 3-methyladenine (3-MA), is commonly used to selectively block autophagy. Recent findings suggest a strong relationship between autophagy and lipid turnover. Here, we explore the effect of 3-MA on adipocyte lipolysis. EXPERIMENTAL APPROACH Assays were performed in 3T3-L1 cells. Cells treated with wortmannin, pan inhibitor. Pharmacological genetic manipulation endogenous autophagic lipolytic pathways was ascertain contribution observed...

Latent tuberculosis infection (LTBI) relies on a homeostasis of macrophages and Mycobacterium (Mtb). The small heat shock protein, Mtb Hsp16.3 (also known as latency-associated antigen), plays an important role in persistence within macrophages. However, the mechanism LTBI remains elusive. aim this study was to delineate LTBI-related miRNA expression U937 expressing protein. were infected with integrase-deficient Lentivirus vector transiently express Hsp16.3, green fluorescent protein (GFP)...

Adipose triglyceride lipase (ATGL) is the key triacylglycerol hydrolase in adipocytes. The precise mechanisms by which ATGL action regulated lipid droplet (LD) coat proteins and responds to hormonal stimulation are incompletely defined. By combining usage of loss- gain-of-function approaches, we sought determine respective roles perilipin 1 fat-specific protein 27 (FSP27) control ATGL-mediated lipolysis Knockdown endogenous expression resulted elevated basal that was less responsive...

A new ex-TTF-based organogelator with L-glutamide-derived lipid unit (compound 1) was synthesized and characterized. The resulting transparent organogels can be obtained several organic solvents such as toluene, DMSO, ethanol. It is interesting that its gelation ability further enhanced by addition of C(60). (1)H NMR absorption spectral studies indicate the intermolecular interaction between ex-TTF in 1 C(60) may responsible for this phenomenon. Further imply assembly structures gel phases...

Given the strong link between visceral adiposity and (hepatic) insulin resistance as well liver steatosis, it is crucial to characterize obesity-associated alterations in adipocyte function, particularly fat depots drained liver. Yet these adipose tissues are not easily accessible humans, most frequently studied depot rodents perigonadal, which systemically. In present study, we aimed study lipolysis mesenteric perigonadal adipocytes mice. Basal free fatty acid glycerol release was...

The New Delhi Metallo-β-lactamase (NDM) is among the most threatening forms of carbapenemases produced by K. pneumoniae, well-known to cause severe worldwide infections. molecular epidemiology blaNDM-1-harboring pneumoniae not well elucidated in Pakistan. Herein, we aim determine antibiotics-resistance profile, genes type, and plasmid analysis 125 clinically isolated strains from urine samples during July 2018 January 2019 A total 34 (27.2%) isolates were producers, 23 (18.4%) harbored...

The multiple-drug resistant Escherichia coli are among the deadliest pathogens causing life-threatening infections. This study was planned to determine molecular epidemiology of mcr-1, blaKPC-2, and blaNDM-1 harboring clinically isolated E. from Pakistan.In total, 545 strains clinical samples were collected June 2018 September 2019. All isolates screened for colistin-resistance, extended-spectrum-β-lactamases (ESBL), carbapenemases through micro-dilution method, Double-Disk-Synergy-Test...

Abstract The self‐assembly of a tetrathiafulvalene (TTF)‐based molecular gelator with dendron substituent into gel is described. Scanning electron microscope and atomic force studies show that the xerogels exhibit rope‐like frameworks or interwoven nanofibers, depending on polarity solvent from which formed. Gels containing chloranil can also be successfully prepared. Interestingly, this two‐component easily transformed solution after addition either Sc 3+ Pb 2+ . Both absorption spin...

Hepatic lipid accumulation is closely associated with nonalcoholic fatty liver disease (NAFLD). Adipose-triglyceride-lipase (ATGL) regulates triglyceride hydrolysis and maintains energy homeostasis in hepatocytes. Identifying key factors the regulation of ATGL will help tackle hepatic related metabolic diseases. Herein, we demonstrate that syntaxin11 (STX11), a member SNARE family, generally expressed immune cells, mediates metabolism by binding to inhibiting droplet degradation autophagy...

To better understand the structure and function of myostatin's gene promoter region in sheep, we cloned sequenced a 1.517 kb fragment containing 5'-regulatory sheep myostatin (GenBank accession number is AY918121). The sequence consists three TATA boxes, one CAAT box, eight putative E-boxes. Some muscle growth response elements for Octamer-binding factor 1(Octamer), Activator protein 1(AP1), Growth independence 1 zinc finger (Gfi-1B), Myocyte enhancer 2 (MEF2), Muscle-specific Mt binding...

A new C60-based low-molecular weight gelator (LMWG 1) with a L-glutamid-derived lipid unit was synthesized and characterized. LMWG 1 can gel toluene, p-xylene benzene. Moreover, its gelation ability be further enhanced by addition of an exTTF derivative (compound 2), for which the intermolecular interaction between C60 in 2 is responsible based on absorption NOE difference 1H-NMR spectral studies. Additionally, gelation-induced CD signals are observed that doped compound 2. Further studies...

Autophagy is an intracellular catabolic system. It delivers cellular components to lysosomes for degradation and supplies nutrients that promote cell survival under stress conditions. Although much known regarding starvation-induced autophagy, the regulation of autophagy by energy level less clear. BRUCE ubiquitin conjugase ligase with multi-functionality. has been reported depletion inhibits blockage fusion step. Herein we report a new function in dual energy. Depletion alone (without...