A5068188257- Insect Pest Control Strategies
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Agricultural pest management studies
- Mosquito-borne diseases and control
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Fungal Infections and Studies
- Insect-Plant Interactions and Control
- Insect Resistance and Genetics
- Fungal Biology and Applications
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Insect and Pesticide Research
- Antibiotics Pharmacokinetics and Efficacy
- Pediatric Hepatobiliary Diseases and Treatments
- Nail Diseases and Treatments
- Bacterial Identification and Susceptibility Testing
- Musculoskeletal pain and rehabilitation
- Psoriasis: Treatment and Pathogenesis
- Enterobacteriaceae and Cronobacter Research
- Atherosclerosis and Cardiovascular Diseases
- Stroke Rehabilitation and Recovery
- Phytochemical compounds biological activities
- Gut microbiota and health
Jiangxi Provincial Cancer Hospital
2024-2025
Dalian Medical University
2022-2025
Second Affiliated Hospital of Shantou University Medical College
2022-2024
Shantou University
2022-2024
Khyber Medical University
2021-2024
Simon Fraser University
2024
Jinnah Sindh Medical University
2022-2023
Jinnah Postgraduate Medical Center
2022-2023
Shantou University Medical College
2023
Hazara University
2023
The increased use of colistin against infections caused by Acinetobacter baumannii and Pseudomonas aeruginosa has resulted in resistance. purpose this study was to detect plasmid-mediated mcr-1 gene colistin-resistant A. P. isolates.A total 146 clinical isolates (n = 62) 84) were collected from the four largest tertiary care hospitals Peshawar, Pakistan. All bacterial phenotypically screened for multidrug resistance using Kirby-Baur disc diffusion method. minimum inhibitory concentration...
The emergence of pathogens is conferring resistance to last-resort therapies such as tigecycline, colistin, and carbapenems, limiting the therapeutic options, raising concerns about new "superbugs." This study reports first incident a blaNDM-5 tet(X4) co-harboring Escherichia coli with carbapenem tigecycline recovered causative agent urinary tract infection in 94-year-old patient. E. strain ECCL209 carries multiple genes [i.e., blaTEM-1B , blaNDM-5, blaCMY-2, aadA22, florR, erm(B), mph(A),...
Interleukins (ILs) are vital in regulating the immune system, enabling to combat fungal diseases like candidiasis effectively. Their inhibition may cause enhanced susceptibility infection. IL inhibitors have been employed control autoimmune and of IL-17 IL-23, for example, associated with an elevated risk
Before the emergence of plasmid-mediated colistin resistance, was once considered last drug choice for infections caused by carbapenem-resistant bacteria. Currently, researchers are relentlessly exploring possible alternative therapies that could efficiently curb spread resistance. In this study, we aim to investigate synergistic antibacterial activity tetrandrine in combination with against mcr-1-harboring Escherichia coli. We examined vivo and vitro bacterial cells fluorescence, scanning,...
Facial microbiota dysbiosis is an important factor in causing acne vulgaris. The present study aimed to analyze the effect of 2% Supramolecular Salicylic Acid (SSA) on acne-associated facial bacteria. In current study, 30 vulgaris patients (treated with SSA for eight weeks) and ten volunteers no were selected. Samples from (before after treatment) (not treated) analyzed via high throughput sequencing, Deblur algorithm, R microbiome package. After treatment SSA, total lesion count global...
Current diagnostic biomarkers for acute myocardial infarction (AMI), such as troponins, often lack specificity, leading to false positives under non-cardiac conditions. Recent studies have implicated circadian rhythm and immune infiltration in the pathogenesis of AMI. This study hypothesizes that analyzing interplay between rhythm-related gene expression identify highly specific Our results demonstrated differential 15 genes (CRGs) AMI patients healthy individuals, with five key genes-JUN,...
<div>Abstract<p>Fungal dysbiosis is increasingly recognized as a key factor in cancer, influencing tumor initiation, progression, and treatment outcomes. This review explores the role of fungi carcinogenesis, with focus on mechanisms such immunomodulation, inflammation induction, microenvironment remodeling, interkingdom interactions. Fungal metabolites are involved oncogenesis, antifungals can interact anticancer drugs, including eliciting potential adverse effects immune...
<p>Table S1: Extra-tumoral fungi in association with various cancer types. Figure Interactions of Candida species the immune system and their roles development (a): C. albicans triggers Th17/IL-17 responses, recruiting M2-like TAMs promoting oral cancer. (b): translocate to liver, inducing Th17/Th1 leading inflammation liver (c): spp upregulates MDSCs gut, driving evasion CRC. interacts Dectin-3 on macrophages, IL-22 production contributing tropicalis CARD9-expressing which recruit...
Candidiasis poses a significant threat to human health, especially in immunocompromised patients. However, there is paucity of epidemiological data concerning the prevalence candidiasis developing regions China. We conducted retrospective study on patients positive for Candida infections tertiary care hospital Shantou, China, identify clinical characteristics and risk factors candidiasis. Of 5,095 cases candidiasis, 489 (9.59%) were candidemia infections. albicans (n = 230, 47.0%) was...
Wilson disease is a genetic disorder related to copper metabolism that follows an autosomal recessive pattern. Objectives: To document the clinical and pathological spectrum of at tertiary setting in Punjab, Pakistan. Methods: This cross-sectional study was conducted Department Pediatric Gastroenterology, Children's Hospital, Faisalabad, Pakistan, from December 2019 October 2024. A total 60 children both genders aged below 18 years, presenting with were analyzed. Physical examinations...
To investigate the occurrence and molecular features of ESBL-producing colistin-resistant Escherichia coli isolates recovered from healthy food-producing animals in Pakistan.A total 153 E. were 250 faecal samples collected livestock poultry. The antibiotic susceptibility, resistant determinants mobile genetic elements determined for all isolates. clonal relatedness was analysed by MLST. Plasmids harbouring, localization transferability mcr-1 gene carried out Southern hybridization, S1-PFGE...
The application of interleukin-17 (IL-17) inhibitors, including secukinumab, ixekizumab, brodalumab, and bimekizumab, are associated with elevated risk candidiasis. These medications interfere the IL-17 pathway, which is essential for maintaining mucosal barriers coordinating immune response against Candida species. observational data clinical trials demonstrate increased incidence candidiasis in individuals treated inhibitors. Brodalumab bimekizumab pose a greater than secukinumab eliciting...
The New Delhi Metallo-β-lactamase (NDM) is among the most threatening forms of carbapenemases produced by K. pneumoniae, well-known to cause severe worldwide infections. molecular epidemiology blaNDM-1-harboring pneumoniae not well elucidated in Pakistan. Herein, we aim determine antibiotics-resistance profile, genes type, and plasmid analysis 125 clinically isolated strains from urine samples during July 2018 January 2019 A total 34 (27.2%) isolates were producers, 23 (18.4%) harbored...
The multiple-drug resistant Escherichia coli are among the deadliest pathogens causing life-threatening infections. This study was planned to determine molecular epidemiology of mcr-1, blaKPC-2, and blaNDM-1 harboring clinically isolated E. from Pakistan.In total, 545 strains clinical samples were collected June 2018 September 2019. All isolates screened for colistin-resistance, extended-spectrum-β-lactamases (ESBL), carbapenemases through micro-dilution method, Double-Disk-Synergy-Test...
Hepatic lipid accumulation is closely associated with nonalcoholic fatty liver disease (NAFLD). Adipose-triglyceride-lipase (ATGL) regulates triglyceride hydrolysis and maintains energy homeostasis in hepatocytes. Identifying key factors the regulation of ATGL will help tackle hepatic related metabolic diseases. Herein, we demonstrate that syntaxin11 (STX11), a member SNARE family, generally expressed immune cells, mediates metabolism by binding to inhibiting droplet degradation autophagy...