A5019394436- Mesenchymal stem cell research
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Use and Resistance
- Colorectal Cancer Screening and Detection
- Genetic and Environmental Crop Studies
- Pluripotent Stem Cells Research
- Liver physiology and pathology
- Bacterial Identification and Susceptibility Testing
- Barrier Structure and Function Studies
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- Skin Protection and Aging
- Chemokine receptors and signaling
- Ferroptosis and cancer prognosis
- Multiple Myeloma Research and Treatments
- Food Allergy and Anaphylaxis Research
- Eating Disorders and Behaviors
- Hormonal and reproductive studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nerve injury and regeneration
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
Shantou University Medical College
2005-2024
Shantou University
2005-2024
Nanjing Agricultural University
2018
Southern Medical University
2016
Brain injury after intracranial hemorrhage (ICH) results in significant morbidity and mortality. Blood brain barrier (BBB) disruption is a hallmark of ICH-induced injury; however, data mirroring BBB human ICH are scarce. The aim this study was to assess the significance circulating biomarkers evaluating ICH. Twenty-two patients with were recruited study. Concentrations tight junction proteins (TJs) Claudin-5 (CLDN5), Occludin (OCLN), zonula occludens 1 (ZO-1) vascular endothelial growth...
Background. Accurate analysis of intestinal microbiota will facilitate establishment an evaluating system for assessing colorectal cancer (CRC) risk and prognosis. This study evaluates the potential role Fusobacterium nucleatum (F. nucleatum) Escherichia coli with a pks gene (pks+ E. coli) in early CRC diagnosis. Methods. We recruited 139 patients, including ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>n</a:mi> <a:mo>=</a:mo> <a:mn>60</a:mn> </a:math> ), adenomatous...
To investigate the occurrence and molecular features of ESBL-producing colistin-resistant Escherichia coli isolates recovered from healthy food-producing animals in Pakistan.A total 153 E. were 250 faecal samples collected livestock poultry. The antibiotic susceptibility, resistant determinants mobile genetic elements determined for all isolates. clonal relatedness was analysed by MLST. Plasmids harbouring, localization transferability mcr-1 gene carried out Southern hybridization, S1-PFGE...
Human umbilical cord mesenchymal stem cells (HUMSCs) are highly proliferative and can be induced to differentiate into advanced derivatives of all three germ layers. Thus, HUMSCs considered a promising source for cell-targeted therapies tissue engineering. However there reports on spontaneous transformation (MSCs) derived from human bone marrows. The capacity undergo malignant transform spontaneously or via induction by chemical carcinogens is presently unknown. Therefore, we isolated 10...
Aim . FilmArray Respiratory Panel (FilmArray RP) test is an emerging diagnostic method in fast detecting multiple respiratory pathogens; the methodology and clinical significance of RP community-acquired pneumonia (CAP) diagnosis were evaluated this study. Methods Specimens from 74 patients with CAP analyzed compared using RP, traditional PCR assay, bacterial (or fungal) culture, serological detection. Results multiplex showed 100% coincidence rate coronaviruses 229E, OC43, HKU1, NL63, human...
Platelet indices could mirror megakaryopoietic activity in immune thrombocytopenic purpura (ITP), but its specificity and sensitivity need to be studied. The diagnostic performance of platelet was analyzed by receiver-operating characteristic curves, the probability true positive (sensitivity) negative (specificity) predicting ITP, myelodysplasia, or controls determined. Mean volume (MPV) higher, whereas plateletcrit (PCT) significantly lower ITP than myelodysplasia controls. distribution...
Due to the growing availability of genomic datasets, machine learning models have shown impressive diagnostic potential in identifying emerging and reemerging pathogens. This study aims use techniques develop compare a model for predicting bacterial resistance panel 12 classes antibiotics using whole genome sequence (WGS) data Pseudomonas aeruginosa.A technique called Random Forest (RF) BioWeka was used classification accuracy assessment logistic regression (LR) statistical analysis.Our...
Acne is the eighth-most prevalent inflammatory skin disease with no optimal treatment. Photodynamic therapy (PDT) an effective treatment for severe acne.
Triple-negative breast cancer (TNBC) accounts for 15–20% of all cases. Due to the lack expression well-known molecular targets [estrogen receptor (ER), progesterone (PR), and human epidermal growth factor 2 (HER2)], there is a need more alternative treatment approaches in TNBC. Chimeric antigen (CAR)-T cell-based immunotherapy one latest technologies with outstanding therapeutic advances past decade, especially hematologic malignancies, but effects CAR-T cells against solid tumors have not...
The aim of this study was to evaluate the clinical significance circulating tight junction (TJ) proteins as biomarkers reflecting leukaemia central nervous system (CNS) metastasis. TJs [claudin5 (CLDN5), occludin (OCLN) and ZO-1] concentrations were measured in serum cerebrospinal fluid (CSF) samples obtained from 45 patients. Serum ZO-1 significantly higher (p < 0.05), but CSF levels not CNS (CNSL) compared non-CNSL. CNSL patients also had a lower CLDN5/ZO1 ratio both than non-CNSL 0.05)....
Background: The lack of a stable source hepatocytes is one major limitations in hepatocyte transplantation and clinical applications bioartificial liver. Human embryonic stem cells (hESCs) with high degree self-renewal totipotency are potentially limitless variety cell lineages, including hepatocytes. Many techniques have been developed for effective differentiation hESCs into functional hepatocyte-like cells. However, the application hESC-derived (hESC-Heps) clinic has constrained by low...
Aim: The gut microbiome plays a crucial role in colorectal cancer (CRC) tumorigenesis, but compositions of microorganisms have been inconsistent previous studies due to the different types specimens. We investigated microbiomes and resistomes CRC patients with colonic biopsy tissue intestinal lavage fluid (IVF). Methods: Paired samples (biopsy IVF) were collected from 20 CRC, their measured by shotgun metagenomics. Clinical laboratory data recorded. Bioinformatics (KneadData, Kraken2, FMAP)...
Leukemia poses significant challenges to its treatment, and understanding complex pathogenesis is crucial. This study used metagenomic sequencing investigate the interplay between chemotherapy, gut microbiota, antibiotic resistance in patients with acute leukemia (AL). Pre- post-chemotherapy stool samples from revealed alterations microbial richness, taxa, genes (ARGs). The analysis a decreased alpha diversity, increased dispersion samples, changes abundance of specific bacteria. Key...
In this study, we collected different levels of altered rocks a rocky mountain and the adjacent soil characterized abundance weathering effectiveness Bacillus strains. Based on qPCR culture‐dependent approaches, gene copies or numbers strains were significantly higher in than rocks, while ratio to those total bacteria was less rock, followed by more rock soil. The relative highly active Al‐solubilizing Among species, 30–36% them between soil, however, similar species found ones. results...
Cow milk protein allergy (CMPA) is a significant health concern characterized by adverse immune reactions to cow proteins. Biomarkers for the accurate diagnosis and prognosis of CMPA are lacking. This study analyzed clinical features CMPA, 16S RNA sequencing was used investigate potential biomarkers through fecal microbiota profiling. Children with exhibit range symptoms, including gastrointestinal (83% patients), skin (53% respiratory manifestations (26% highlighting complexity this...
Abstract To study the role of intestinal flora in development bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into their was measured by 16S rRNA gene sequencing. The bacterial diversity significantly lower BSI group compared with that HCs (P < 0.001), beta differentiated between two groups (PERMANOVA, P = 0.001). four keystone species [ Roseburia , Faecalibacterium Prevotella Enterococcus (LDA > 4)] differed groups. Dysbiosis fecal microbial...