A5101543549- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Urticaria and Related Conditions
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Memory and Neural Mechanisms
- Long-Term Effects of COVID-19
- Neurogenesis and neuroplasticity mechanisms
- Spondyloarthritis Studies and Treatments
- Autoimmune Bullous Skin Diseases
- Dermatological diseases and infestations
- Mast cells and histamine
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Photodynamic Therapy Research Studies
- Alzheimer's disease research and treatments
- Skin Protection and Aging
- Food Allergy and Anaphylaxis Research
- Heart Rate Variability and Autonomic Control
- COVID-19 diagnosis using AI
- Histiocytic Disorders and Treatments
- Phytochemistry Medicinal Plant Applications
- Inflammatory Biomarkers in Disease Prognosis
Shantou University
2010-2025
First Affiliated Hospital of Shantou University Medical College
2010-2025
Nanjing Drum Tower Hospital
2023
Nanjing Medical University
2023
ORCID
2023
Chang Gung Memorial Hospital
2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2018-2020
Southern Medical University
2016-2018
Nanfang Hospital
2016-2018
Ruijin Hospital
2018
The effect of air pollution on the changing pattern glomerulopathy has not been studied. We estimated profile and temporal change in glomerular diseases an 11-year renal biopsy series including 71,151 native biopsies at 938 hospitals spanning 282 cities China from 2004 to 2014, examined association long-term exposure fine particulate matter <2.5 μm (PM2.5) with glomerulopathy. After age region standardization, we identified IgA nephropathy as leading type glomerulopathy, a frequency 28.1%,...
<h3>Importance</h3> Recent studies have shown an association between psoriasis and nonalcoholic fatty liver disease (NAFLD) in US inpatients, but the is still unclear outpatient population. <h3>Objective</h3> To assess whether associated with NAFLD adults. <h3>Design, Setting, Participants</h3> This population-based cross-sectional study used data on adults aged 20 to 59 years from National Health Nutrition Examination Survey (NHANES) 2003-2006 2009-2014 cycles. Data were analyzed June...
The pathogenesis of chronic urticaria (CU) is closely related to imbalances in immunity. gastrointestinal microflora provides a vast and continuous stimulation for the immune system. However, composition diversity gut CU patients are rarely reported.10 10 healthy individuals were selected this study, their intestinal microbiome was detected by 16S rRNA sequencing. data analyzed using R language software.392 bacterial OTUs common groups, but there 159 particularly existing group, while 87...
Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease Chinese lacking.In a nationwide biopsy survey including 71,151 native from 2004 to 2014, were identified according the clinical diagnosis referral records. The extracted records pathological reports.A total 1,604 patients, 61 with T1DM, analyzed this study. median age is 51.39 ± 11.37 years. Male accounted for 58% population. We found...
Microglial activation is involved in a variety of neurological disorders, and overactivated microglial cells can secrete large amount proinflammatory factors induce neuron death. Therefore, reducing believed to be useful treating the disorders. In this study, we used 10 ng/ml lipopolysaccharide plus U/ml interferon γ (LPS/IFNγ) N9 explored resveratrol- (RSV-) induced effects on underlying mechanism. We found that LPS/IFNγ exposure for 24 h increased inducible nitric oxide synthase (iNOS)...
Acne is the eighth-most prevalent inflammatory skin disease with no optimal treatment. Photodynamic therapy (PDT) an effective treatment for severe acne.
Background Psoriasis is a chronic dermatological condition characterized by complex pathogenesis that impacts approximately 3% of adults in the United States and brings enormous social burdens. For many diseases, systemic immune-inflammatory index (SII), defined as neutrophils × platelets/lymphocytes, has been recognized prognostic indicator. Therefore, we conducted cross-sectional study to assess association between SII psoriasis among outpatient US adults. Methods In this study, used data...
Clinical, laboratory, and computed tomography (CT) findings of 5 cases the novel Coronavirus Disease 2019 (COVID-19) pneumonia from patients outside Wuhan were reviewed. The human-to-human transmission virus may explain infection disease Wuhan. CT examination is important in early detection follow-up disease. With a history exposure or travelling, symptoms fever cough, typical manifestation such as ground-glass opacity with peripheral distribution, we should also think possibility COVID-19
Background. Chemokines may be involved in the pathogenesis of urticaria, but their correlation with disease severity as well eruption type is unclear. Objectives. The aim this study was to explore expression chemokines patients urticaria. association between and levels analysed. Materials Methods. Serums CCL11, CCL17, CCL26, CCL27, D-dimer, C-reactive protein, total IgE were measured 51 urticaria 25 healthy control subjects. Results. CCL27 significantly higher than controls (<mml:math...
We have recently demonstrated that adeno-associated virus serotype 9 (AAV9)-mediated human erythropoietin (hEPO) gene delivery into the brain protects dopaminergic (DA) neurons in substantia nigra a rat model of Parkinson's disease. In present study, we examined whether pre-exposure to AAV9-hEPO vectors with an intramuscular or intrastriatal injection would reduce AAV9-mediated hEPO transduction brain. first characterized transgene expression and immune responses against striatum at 4 days,...
<b><i>Background:</i></b> Topical agents are still the mainstay for treatment of mild-to-moderate plaque psoriasis, in which fixed combinations play an important role. Tazarotene/betamethasone dipropionate (Taz/BD) cream is a novel combination approved treating psoriasis China, but its efficacy and safety have not been verified real-world environment. <b><i>Objectives:</i></b> The primary objective was to investigate Taz/BD psoriasis. secondary...
Motivation: Identify individuals at risk of developing post-COVID fatigueGoal(s): Propose a "vulnerability" hypothesis fatigueApproach: A multi-center, prospective, longitudinal studyResults: The GMV in frontal-limbic regions may serve as potential neural underpinnings that identify fatigueImpact: Our findings emphasized the essential role system development fatigue, which will improve public health interventions by allowing for early identification persistent fatigue and facilitating...
The objective of this study was to investigate the mechanism soluble Aβ oligomer-induced alteration in synaptic proteins. Therefore, an immunofluorescence technique applied changes expression postsynaptic density-95 (PSD-95) protein primary hippocampal neurons, which exposed Aβ<sub>25–35</sub> after N-methyl-D-aspartate receptor (NMDAR) antagonist or agonist treatment. Results showed that downregulated PSD-95 a dose- and time-dependent manner. Treatment cells with MK-801 (a...
Abstract Background hay fever may increase the risk of atopic dermatitis. However, few studies have investigated joint effects and alcohol drinking status on Therefore, we aimed to explore association between fever, dermatitis, status. Methods 4754 participants aged over 20 years from National Health Nutrition Examination Survey (NHANES) in 2005–2006 were involved study. Hay was defined by self-reported medical diagnosis, dermatitis assessed question “Has a doctor or other health...
Abstract Hypoxic–ischemic brain damage (HIBD) in the perinatal period is an important cause of cerebral and long-term neurological sequelae, can place much pressure on families society. Our previous study demonstrated that miRNA-326 reduces neuronal apoptosis by up-regulating δ-opioid receptor (DOR) under oxygen–glucose deprivation vitro. In present study, we aimed to explore neuroprotective effects miRNA-326/DOR axis inhibiting HIBD using neonatal knockout mice. Neonatal C57BL/6 mice, mice...
Objective To investigate the characteristic of event-related potentials(ERPs) N400 between healthy adult and lupus encephalopathy patients.Methods The patients were randomly divided into 20 cases re-search group control they studied with Event-Related Potentials N400.Results Compared group,research had a positive correlation averaged wave amplitude Nd00(P<0.05).Conclusion ERPs in extended incubation period shortening amplitude. Key words: Lupus eythematosus,systemic; Neuropsyehiatric...