A5018117166- Chemical and Physical Properties in Aqueous Solutions
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Crystallization and Solubility Studies
- Molten salt chemistry and electrochemical processes
- Drug-Induced Adverse Reactions
- Cancer Immunotherapy and Biomarkers
- Extraction and Separation Processes
- Psoriasis: Treatment and Pathogenesis
- Dermatologic Treatments and Research
- Circadian rhythm and melatonin
- Chemical Looping and Thermochemical Processes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neurobiology and Insect Physiology Research
- Monoclonal and Polyclonal Antibodies Research
- Melanoma and MAPK Pathways
- Colorectal Cancer Treatments and Studies
- Traditional Chinese Medicine Analysis
- Insect and Arachnid Ecology and Behavior
- Adipose Tissue and Metabolism
- Infectious Diseases and Mycology
- Hemophilia Treatment and Research
- Berberine and alkaloids research
- Phytochemistry Medicinal Plant Applications
- Calcium signaling and nucleotide metabolism
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Peking Union Medical College Hospital
2013-2025
Xi'an Medical University
2019-2024
Kunming Medical University
2024
Chengdu University of Technology
2019-2024
Xinyang Normal University
2023-2024
National Clinical Research Center for Digestive Diseases
2020
Southwest Medical University
2018
China Agricultural University
2008-2015
Monash University
2012
Abstract This study explores the potential mechanisms of obstructive sleep apnoea (OSA) complicates type 2 diabetes mellitus (T2DM) by which chronic intermittent hypoxia (CIH) induces insulin resistance and cell apoptosis in pancreas through oxidative stress. Four‐ eight‐week CIH rat models were established, Tempol (100 mg/kg/d), was used as an stress inhibitor. included five groups: 4‐week CIH, CIH‐Tempol, 8‐week CIH‐Tempol normal control (NC) groups. Fasting blood glucose levels measured...
Most organisms have behavioral and physiological circadian rhythms, which are controlled by an endogenous clock. Although genetic analysis has revealed the intracellular mechanism of clock, manner in this clock communicates its temporal information to produce systemic regulation is still largely unknown.Sleep behavior was measured using Drosophila Activity Monitoring System (DAMS) monitor under a 12 h light:12 dark cycle constant darkness (DD), 5 min without recorded activity were defined as...
Few clinical trials have evaluated the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) compared with acitretin in psoriasis. We aimed to compare TwHF treatment moderate severe psoriasis vulgaris.Adults Psoriasis Area Severity Index (PASI) score ≥ 10 psoriasis-affected body surface area 10% were randomized into a (20 mg, 3 times day) or group (30 once day). The course lasted for 8 weeks. Patients assessed at baseline 2, 4, Laboratory tests performed baseline, week 8. data analyzed...
Injectable hyaluronic acid fillers have been widely applied in the clinical treatment of facial wrinkles. However, further information and evidence concerning dermal changes filler longevity after injection diffusion pattern are limited.The authors evaluated two generated by different cross-linking technologies used nasolabial folds using high-frequency ultrasound. Forty-one subjects were treated with Restylane 2 remaining 41 Dermalax DEEP. Wrinkle severity rating scale score ultrasound...
The necessity for tuberculosis preventive treatment (TPT) and routine T-SPOT.TB monitoring in patients with psoriasis infection (TBI) undergoing interleukin (IL)-17A inhibitor therapy remains uncertain. This study aims to evaluate the long-term safety of IL-17A inhibitors administered without TPT analyze changes among these patients. It also identifies risk factors TBI psoriasis. single-center prospective enrolled adult plaque receiving inhibitors. was defined as positive results (≥ 6 spots)...
Nontuberculous mycobacteria (NTM) are emerging pathogens responsible for increasing skin and soft tissue infections (SSTIs) globally. However, the diagnosis treatment of NTM SSTIs face significant challenges due to lack standardized guidelines. This study reviewed clinical characteristics, diagnostic challenges, outcomes in a large cohort from tertiary referral center Beijing, China. We retrospectively 142 patients diagnosed with at hospital 2014 2023. Data collected included presentation,...
Abstract Circadian rhythms in behaviour and physiology exist widely animals, plants, fungi cyanobacteria. Although much work has been carried out to characterize the endogenous clock circuit, output signals coupling circadian pacemaker remain elusive. Here, we show that neuropeptide F ( NPF ), a homologue of mammalian Y , its G protein‐coupled receptor NPFR1 regulate locomotor rhythm D rosophila melanogaster . Flies with loss function or were unable ramp up their activity before lights off...
An on-line SPE-HPLC method, using a monolithic poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (poly(GMA-EDMA)) based weak cation-exchange (WCX) column, was developed for simultaneous determination of alpha1-adrenergic receptor antagonists in human plasma. The WCX column prepared by an in-situ polymerization protocol and modified stepwise with ethylenediamine chloroacetic acid. On connecting this to injection valve, SPE could be established removal matrices (mainly proteins...
Abstract Bullous pemphigoid ( BP ) is an autoimmune subepidermal bullous disease, and different immunoglobulin (Ig)G autoantibody subclasses may play roles in the pathogenesis of . This study aims to evaluate relationship between specific IgG Enzyme‐linked immunoassays ELISA were developed test targeting non‐collagenous 16A NC 16A) domain 180. A statistical analysis was carried out assess as well other factors. The correlation coefficients scores for four disease severity 0.586 IgG, 0.441...
Psoriasis is a chronic, recurrent skin disease requiring long-term management. Agents that repair the skin's barrier function are invaluable additives in topical treatments of psoriasis. This multicenter, randomized, controlled trial evaluated efficacy and safety linoleic acid-ceramide-containing moisturizer (LA-Cer) for mild-to-moderate psoriasis vulgaris. We randomized 178 patients from both northern southern regions China into two groups: 81 control group received mometasone furoate (MF,...
This prospective observational study investigated whether interleukin (IL)-17A inhibitors could reduce serum uric acid (SUA) levels in psoriatic patients with hyperuricemia. It also explored the risk factors for hyperuricemia and effectiveness of IL-17A skin lesions
The ternary system LiCl–SrCl2–H2O and the quaternary KCl–LiCl–SrCl2–H2O at 308 K were investigated using isothermal dissolution equilibrium method. According to obtained experimental results, phase diagrams of two systems listed above plotted separately. results show that both belong hydrate I-type cosaturated K, there are no double salts or solid solution formation. Lithium chloride has strong salting-out effect on strontium potassium chloride. There invariant points, three univariate...
Introduction Immune-related epidermal necrolysis (irEN), including Stevens-Johnson Syndrome (SJS) and toxic (TEN), represents a potentially lethal reaction to immune checkpoint inhibitors. An optimal treatment strategy remains undefined. This study evaluates the effectiveness safety of combination therapy with corticosteroids tumor necrosis factor inhibitors (TNFi) in treating irEN patients. Methods In this single-center, prospective, observational study, patients received either...
Background: We previously have proved that sodium tanshinone II-A sulfonate (DS-201), a derivative of traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), is an opener and vasodilator BKCa channel in the vascular smooth muscle cells (VSMCs). Vascular tension closely associated with Ca2+ dynamics activation may not be sole mechanism for relaxation by DS-201. Therefore, we hypothesized vasorelaxing effect DS-20 also related to cytoplasmic level VSMCs. Methods: Arterial was...