A5100461426- Atrial Fibrillation Management and Outcomes
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Biofuel production and bioconversion
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Gastric Cancer Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Cancer Genomics and Diagnostics
- Advanced MRI Techniques and Applications
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Neonatal Respiratory Health Research
- Artificial Immune Systems Applications
- Cardiovascular Function and Risk Factors
- Traditional Chinese Medicine Studies
- Respiratory Support and Mechanisms
- Cardiac pacing and defibrillation studies
- Traditional Chinese Medicine Analysis
- Advanced Chemical Sensor Technologies
Chongqing Cancer Hospital
2024-2025
Chongqing University
2024-2025
Hebei Medical University
2011-2025
Wenzhou Medical University
2020-2025
First Affiliated Hospital of Wenzhou Medical University
2020-2025
Fourth Hospital of Hebei Medical University
2025
Nanjing Medical University
2024-2025
Shandong Eye Hospital
2023-2024
Shandong First Medical University
2023-2024
Harbin Medical University
2009-2024
Several of the thousands human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood. LncRNA-HOXD-AS1 was identified by microarray and validated real-time PCR. The clinicopathological significance HOXD-AS1 analyzed Kaplan-Meier method. Chromatin immunoprecipitation conducted to examine mechanism upregulation. role HCC cells assessed both vitro vivo. ceRNA function evaluated RNA...
Background and Aims Aristolochic acid (AA) exposure has been statistically associated with human liver cancers. However, direct evidence of AA exposure–induced cancer is absent. This study aims to establish a causal relationship between cancers based on mouse model then explores the AA‐mediated genomic alterations that could be implicated in AA‐associated mutational signature. Approach Results We subjected mice, including phosphatase tensin homolog ( Pten )‐deficient ones, aristolochic I...
The differentiation and maturation trajectories of fetal liver stem/progenitor cells (LSPCs) are not fully understood at single-cell resolution, a priori knowledge limited biomarkers could restrict trajectory tracking.We employed marker-free RNA-Seq to characterize comprehensive transcriptional profiles 507 randomly selected from seven stages between embryonic day 11.5 postnatal 2.5 during mouse development, also 52 Epcam-positive cholangiocytes 3.25 livers. LSPCs in developing livers were...
Objective Observational studies have reported that chronic obstructive pulmonary disease (COPD) is often accompanied by autoimmune diseases, but the causal relationships between them remain uncertain. In this Mendelian study, we aimed to investigate potential relationship COPD and four common diseases. Methods We conducted an analysis of summary data on using publicly available genome-wide association (GWAS) data. initially employed inverse- variance weighted method as primary approach...
Nutrient deficiencies restrict apple (Malus sp.) tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway eukaryotic cells, has important roles nutrient-recycling helps improve plant performance during periods nutrient-starvation. Little is known about the functioning autophagy-related genes (ATGs) apple. In this study, one ATG8 gene family members MdATG8i was isolated from Malus domestica. putative tubulin binding sites ATG7 interaction...
The separation of cellulose, hemicellulose, and lignin components using deep eutectic solvent, which is a green to obtain corresponding chemicals can realize the effective high-value utilization these at low cost. In this study, we used waste biomass sugarcane bagasse as raw material, choline chloride hydrogen bond acceptor, lactic acid donor synthesize solvent chloride/lactic (L-DES) treated pretreated by alkali or hydrothermal methods separate lignin. addition, comparatively studied effect...
Abstract Ankylosing spondylitis (AS) is a chronic axial spondyloarthritis (SpA) resulting in back pain and progressive spinal ankyloses. Currently, there are no effective therapeutics targeting AS largely due to elusive pathogenesis mechanisms, even as potential candidates such HLA-B27 autoantigen have been identified. Herein, we employed proteoglycan (PG)-induced mouse model together with clinical specimens, found that the complement system was substantially activated bone marrow,...
Abstract Background The influence of genetic factors on the pharmacokinetics and clinical outcomes rivaroxaban in patients with non-valvular atrial fibrillation (NVAF) is poorly understood. This study aimed to explore effects CYP3A4/5 , ABCB1 ABCG2 gene polymorphisms trough concentrations bleeding risk NVAF patients. Patients methods a prospective multicenter study. patient's blood samples were collected detect steady-state polymorphisms. We visited regularly at month 1, 3, 6, 12 record...
Abstract Background 5-Azacytidine (AZA) combined with the BCL2 inhibitor Venetoclax (VEN) is standard treatment for elderly acute myeloid leukemia (AML) patients or those who are unfit intensive chemotherapy (elderly AML). However, an effective and rapid predictive biomarker to predict outcome remains elusive. Methods miR-182 promoter methylation was measured in 94 AZA + VEN-treated AML 20 normal controls (NCs) samples. To determine whether a marker of clinical outcomes real-world setting,...
The objective of this study was to elucidate the relationship between two single nucleotide polymorphisms (SNPs) rs7176005 and rs6493497 in CYP19 gene risk polycystic ovary syndrome (PCOS) Northern Chinese women. In case-control study, a total 340 women with PCOS matched healthy controls were recruited. Polymerase chain reaction ligase detection (PCR-LDR) method used investigate SNPs (rs7176005 rs6493497) 5'-flanking region exon 1. We observed significant association reduced PCOS. Compared...
Very high gravity (VHG) fermentation using medium in excess of 250 g/L sugars for more than 15% (v) ethanol can save energy consumption, not only distillation, but also distillage treatment; however, stuck with prolonged time and unfermented is the biggest challenge. Controlling redox potential (ORP) during VHG benefits biomass accumulation improvement yeast cell viability that affected by osmotic pressure inhibition, enhancing productivity yield, most important techno-economic aspect fuel...
Abstract Rheumatoid arthritis fibroblast‐like synoviocytes (RA‐FLSs), a pathological hallmark of rheumatoid (RA), exhibit the characteristics tumor cells. The extracts Cirsium japonicum var. ussuriense have been shown to possess antitumor and anti‐inflammatory activities. Our study aimed investigate effects pectolinarin, flavonoid compound isolated from C. , on RA. Cell viability was evaluated by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐tetrazolium bromide assay. Apoptosis determined flow...
Inflammation is a major contributing factor in the development of diabetic microvascular complications, regardless whether improved glycaemic control achieved. Studies have increasingly indicated that fenofibrate, lipid‑lowering therapeutic agent clinical use, exerts potential anti‑inflammatory effect, which mediated by sirtuin 1 (SIRT1; an NAD+‑dependent deacetylase) endothelial cells. The aim present study was to investigate inhibitory effect fenofibrate on metabolic memory (via regulation...