A5101418023- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Connective tissue disorders research
- Medical Imaging and Analysis
- Pelvic and Acetabular Injuries
- MicroRNA in disease regulation
- TGF-β signaling in diseases
- Spinal Cord Injury Research
- Anesthesia and Neurotoxicity Research
- Circular RNAs in diseases
- Bone Metabolism and Diseases
- Congenital Diaphragmatic Hernia Studies
- Cancer, Hypoxia, and Metabolism
- Complement system in diseases
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Immune cells in cancer
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Alcoholism and Thiamine Deficiency
Second Military Medical University
2016-2025
Shanghai Jiao Tong University
2017-2025
Shanghai First People's Hospital
2023-2025
Shanghai Changzheng Hospital
2008-2025
Zhejiang University of Technology
2023-2025
Jinhua Central Hospital
2025
Zhejiang University
2025
Chengdu Medical College
2022-2025
Hunan Institute of Mental Health
2011-2024
Shanghai Ninth People's Hospital
2017-2024
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), one of the first found cancer-associated long noncoding RNAs (lncRNAs), involves in development and progression many types tumors. An aberrant expression MALAT1 was observed hepatocellular carcinoma, cervical cancer, breast ovarian colorectal cancer. However, exact effects molecular mechanisms osteosarcoma are still unknown up to now. Here, we investigated role human cell lines clinical tumor samples order determine function...
Osteosarcoma (OS) is a malignant bone tumor that mainly occurs in adolescents. It accompanied by high rate of lung metastasis, and mortality. Recent studies have suggested the important roles tripartite motif-containing (TRIM) family proteins regulating various substrates signaling pathways different tumors. However, detailed functional role TRIM progression OS still unknown requires further investigations. In this study, we found 22 (TRIM22) was downregulated tissues hence associated with...
Alcohol use disorder (AUD) has been associated with attentional deficits and impairments of working memory. Meanwhile, attention memory are critical for time perception. However, it remains unclear how perception alters in AUD patients affect their The current study aims to clarify the characteristics cognitive mechanisms underlying dysfunction. Thirty-one (three them were excluded) thirty-one matched controls completed Time Bisection Task, Attention Network Test Digital Span Backward assess...
Herein, based on the recently developed magnetic-induced self-assembly techniques, we designed a novel, simple and low-cost method to fabricate special class of photonic crystals with double band-gap hetero-structures, eventually achieved purpose modulating optical diffraction color structural colors. The greatly simplifies fabrication multiple hetero-structures extends modulation means Furthermore, it is worth noting that due resulting colors are derived from consisting peaks presenting...
Abstract Blood vessels play a role in osteogenesis and osteoporosis; however, the of vascular metabolism these processes remains unclear. The present study finds that ovariectomized mice exhibit reduced blood vessel density bone expression endothelial glycolytic regulator pyruvate kinase M2 (PKM2). Endothelial cell (EC)‐specific deletion Pkm2 impairs worsens osteoporosis mice. This is attributed to impaired ability mesenchymal stem cells (BMSCs) differentiate into osteoblasts....
Osteoarthritis (OA) has emerged as a significant health concern among the elderly population, with increasing attention paid to ferroptosis-induced OA in recent years. However, prolonged use of nonsteroidal anti-inflammatory drugs or corticosteroids can lead series side effects and limited therapeutic efficacy. This study aimed employ Mannich condensation reaction between epigallocatechin-3-gallate (EGCG) selenomethionine (SeMet) efficiently synthesize polyphenol-based nanodrugs aqueous...
FGF10 is a member of fibroblast growth factors (FGFs). We previously showed that protects neuron against oxygen-glucose deprivation injury in vitro; however, the effect ischemic stroke vivo unknown. In present study, we was mainly expressed neurons but not astrocytes, and detected mouse cerebrospinal fluid. The levels culture medium cell lysate were much higher than those astrocytes. expression brain tissue level CSF increased middle cerebral artery occlusion (MCAO) model. Administration...
Numerous factors have been claimed to play important roles in colorectal cancer (CRC) tumorigenesis, including myeloid-derived suppressor cells (MDSCs) and other immune cells, cytokines, chemokines; however, the precise mechanisms of tumorigenesis remain elusive, there is a lack effective preventive treatments. Here, we investigated role complement system, key regulator surveillance homeostasis, tumorigenesis. Methods: The prototypical CRC model was induced by combined administration...
Reprogramming metabolism is a hallmark of cancer cells for rapid progression.However, the detailed functional role deubiquitinating enzymes (DUBs) in tumor glycolytic reprogramming still unknown and requires further investigation.USP13 was found to upregulate osteosarcoma (OS) specimens promote OS progression through regulating aerobic glycolysis.Interestingly, m 6 A writer protein, METTL3, has been identified as novel target USP13.USP13 interacts with, deubiquitinates, therefore stabilizes...
Magnetic-functionalized multi-walled carbon nanotubes (MWCNTs) with encapsulated Fe nanoparticles have been successfully fabricated via a one-step decomposition approach using ferrocene as single precursor at high temperature of 950 °C. The constituents, phase, and morphology characterized by X-ray diffraction, Raman spectroscopy transmission electron microscopy (TEM). Magnetic measurements reveal the ferromagnetic nature material magnetization saturation 82.6 emu g−1 room temperature. Full...
Chemotherapy is an important treatment modality for osteosarcoma. However, it often fails because of chemoresistance, especially multidrug resistance. Previously, we found several genes were involved in chemoresistance development. In this report, used high-throughput microRNA (miRNA) expression analysis to reveal that miR-140-5p was associated with chemosensitivity The exact roles the osteosarcoma then investigated, knockdown enhanced cells resistance multiple chemotherapeutics while...
KLF11 is a negative regulator of CSC stemness in sarcoma by repressing YAP/TEAD-dependent transcription.
RNA N6-methyladenosine (m6A) modification is involved in diverse biological processes. However, its role spinal cord injury (SCI) poorly understood. The m6A level increases injured cord, and METTL3, which the core subunit of methyltransferase complex, upregulated reactive astrocytes further stabilized by USP1/UAF1 complex after SCI. specifically binds to subsequently removes K48-linked ubiquitination METTL3 protein maintain stability Moreover, conditional knockout astrocytic both sexes mice...
Targeted transfection of siRNA to preosteoclasts features the potential anti-osteoporosis, yet challenge arises from development satisfied delivery vehicles. Here, we design a rational core-shell nanoparticle (NP) composed cationic and responsive core for controlled load release small interfering RNA (siRNA) compatible polyethylene glycol shell modified with alendronate enhanced circulation bone-targeted siRNA. The designed NPs perform well on an active (siDcstamp) that interferes Dcstamp...
The effect of immunoinflammation on bone repair during the recovery process defects needs to be further explored. It is reported that Mg
Ferroptosis, characterized by iron-dependent phospholipid peroxidation, is recognized as one of the cell death pathways activated following spinal cord injury (SCI). However, precise regulatory mechanisms governing this process remain poorly understood. Here, study identified TRIM32, an E3 ubiquitin ligase, a key enhancer neuronal ferroptosis. TRIM32 promoted ferroptosis accelerating degradation GPX4, which essential inhibitor Conditional deletion Trim32 in neurons markedly inhibited and...