A5015332876- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Connective Tissue Growth Factor Research
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Congenital heart defects research
- Adipokines, Inflammation, and Metabolic Diseases
- Analytical Chemistry and Sensors
- Dermatologic Treatments and Research
- RNA modifications and cancer
- Advanced Chemical Sensor Technologies
- Liver Disease Diagnosis and Treatment
- Gas Sensing Nanomaterials and Sensors
- Diet, Metabolism, and Disease
- Wound Healing and Treatments
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
Second Military Medical University
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
Wenzhou Medical University
2025
Shanghai Changzheng Hospital
2025
Hubei University of Medicine
2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2023
Second Affiliated Hospital of Harbin Medical University
2023
Harbin Medical University
2023
Ferroptosis, characterized by iron-dependent phospholipid peroxidation, is recognized as one of the cell death pathways activated following spinal cord injury (SCI). However, precise regulatory mechanisms governing this process remain poorly understood. Here, study identified TRIM32, an E3 ubiquitin ligase, a key enhancer neuronal ferroptosis. TRIM32 promoted ferroptosis accelerating degradation GPX4, which essential inhibitor Conditional deletion Trim32 in neurons markedly inhibited and...
Current therapies cannot completely reverse advanced atherosclerosis. High levels of amino acids, induced by Western diet, stimulate mTORC1 (mammalian target rapamycin complex 1)-autophagy defects in macrophages, accelerating atherosclerotic plaque progression. In addition, autophagy-lysosomal dysfunction contributes to necrotic core enlargement and lipid accumulation. Therefore, it is essential investigate the novel mechanism molecules acid-mTORC1-autophagy signaling macrophages patients with
Abstract In this study, Sb‐doped SnO 2 nanosphere composite polypyrrole nanohybrid with different doping ratios (0–5 mol%, Sb:Sn) and (0–30 :polypyrrole) is synthesized by hydrothermal method in situ chemical oxidation method. The flexible sensors are fabricated drop‐casting the materials on polyamide substrate gas sensing performances investigated systematically at room temperature. results show that 3 at% 20 mol% /polypyrrole exhibits excellent sensitivity (≈213% toward 100 ppm NH )...
Background: Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) is the best studied member of family coactivators. PGC-1α was initially identified through its interaction with PPARγ in brown adipose tissue. Recent evidence further indicates that may also modulate transcription autophagy-related genes, which has recently been shown to be required for fibroblast-to-myofibroblast differentiation under fibrotic conditions. However, role pathogenesis SSc not investigated....