A5101694046- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- MicroRNA in disease regulation
- Insect symbiosis and bacterial influences
- Neurobiology and Insect Physiology Research
- RNA Research and Splicing
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- NF-κB Signaling Pathways
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- interferon and immune responses
- Antimicrobial Peptides and Activities
- Bone Metabolism and Diseases
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Vector-Borne Animal Diseases
- RNA Interference and Gene Delivery
- Machine Learning in Bioinformatics
- Pancreatic and Hepatic Oncology Research
- Insect and Arachnid Ecology and Behavior
- Studies on Chitinases and Chitosanases
Zhengzhou University
2024-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
Wenzhou Medical University
2025
Henan Cancer Hospital
2024-2025
Nanjing Normal University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Changshu Institute of Technology
2013
Chengdu University of Technology
2011
China Electronic Information Industry Development
2011
Liaocheng University
2010-2011
MicroRNAs (miRNAs) are crucial regulators of gene expression at the post-transcriptional level in eukaryotes via targeting 3'-untranslated regions. Transposable elements (TEs) considered as natural origins some miRNAs. However, what miRNAs and how these originate evolve from TEs remain unclear. We identified 409 TE-derived (386 overlapped with 23 un-overlapped TEs) which derived human. This indicates that play important roles origin In addition, we found proportions (MDTEs) human more than...
Clear cell renal carcinoma (ccRCC) still remains a higher mortality rate in worldwide. Obtaining promising biomakers is very crucial for improving the diagnosis and prognosis of ccRCC patients. Herein, we firstly identified eight potentially prognostic miRNAs (hsa-miR-144-5p, hsa-miR-223-3p, hsa-miR-365b-3p, hsa-miR-3613-5p, hsa-miR-9-5p, hsa-miR-183-5p, hsa-miR-335-3p, hsa-miR-1269a). Secondly, found that signature containing these showed obviously superior to single miRNA effect...
Background We have shown functional expression of several TRP channels on human synovial cells, proposing significance in known calcium dependent proliferative and secretory responses joint inflammation. The present study further characterizes synoviocyte activation to thermal osmotic stimuli after pre-treatment with proinflammatory mediator tumor necrosis factor alpha (TNF-α, EC50 1.3221 × 10 −10 g/L). Results Fluorescent imaging Fura-2 loaded SW982 synoviocytes reveals immediate delayed...
Abstract MicroRNAs (miRNAs) play crucial regulatory roles in controlling immune responses, but their dynamic expression mechanisms are poorly understood. Here, we firstly confirm that the conserved miRNA miR-210 negatively regulates innate responses of Drosophila and human via targeting Toll TLR6, respectively. Secondly, our findings demonstrate is dynamically regulated by NF-κB factor Dorsal response pathway. Thirdly, find Dorsal-mediated transcriptional inhibition dependent on repressor...
Genes carry out their biological functions through pathways in complex networks consisting of many interacting molecules. Studies on the effect network architecture evolution individual proteins will provide valuable information for understanding origin and as well functional conservation signaling pathways. However, relationship between protein sequence is yet little known. In current study, we carried network-level molecular analysis TLR (Toll-like receptor ) pathway, which plays an...
406 Background: The evidence of conversion therapy for unresectable GC/GEJC is limited. Previously, preliminary results the ongoing open-label, phase 2 study (NCT05177068) have showed promising R0 surgical rate (62.1%), resection (100%) and acceptable tolerability in with sintilimab fruquintinib plus SOX (ASCO 2024). Here we present updated longer follow-up duration, including more enrolled patients. Methods: Eligible patients were administered (4mg/d, po, qd, d1-14), (200mg, iv, d1),...
MicroRNAs (miRNAs) are crucial regulators of gene expression at post-transcriptional level. Understanding origin and evolution miRNAs will improve the current available algorithm for prediction novel their functions. Transposable elements (TEs) provide a natural mechanism new miRNAs. In paper, 2,583 derived from TEs (MDTEs) were collected to construct database named MDTE (MDTE DB) storing, searching, analyzing MDTEs. The provides convenient source studying Database...
Abstract Background To survive in a hostile environment, insects have evolved an innate immune system to defend against infection. Studies shown that natural selection may drive the evolution of system-related proteins. Yet, how network architecture influences protein sequence remains unclear. Here, we analyzed molecular evolutionary patterns genes Toll and Imd signaling pathways across six Drosophila genomes within context functional network. Results Based on published literature,...
Drosophila melanogaster is widely used as a model system to study innate immunity and signaling pathways related immunity, including the Toll pathway. Although this pathway well studied, precise mechanisms of posttranscriptional regulation key components by microRNAs (miRNAs) remain obscure. In study, we an in silico strategy combination with Gal80ts-Gal4 driver identify microRNA-958 (miR-958) candidate regulating miRNA We report that overexpression miR-958 significantly reduces expression...
Drosophila Myc (dMyc), as a broad-spectrum transcription factor, can regulate the expression of large number genes to control diverse cellular processes, such cell cycle progression, growth, proliferation and apoptosis. However, it remains largely unknown about whether dMyc be involved in innate immune response. Here, we have identified negative regulator Imd pathway via loss- gain-of-function screening. We demonstrate that inhibits response directly activating miR-277 transcription, which...
The Drosophila Toll signaling pathway mainly responds to Gram-positive (G+) bacteria or fungal infection, which is highly conserved with mammalian TLR pathway. Although many positive and negative regulators involved in the immune response of have been identified Drosophila, roles long noncoding RNAs (lncRNAs) responses are poorly understood date. In this study, our results demonstrate that lncRNA-CR33942 expressed nucleus upregulated after Micrococcus luteus infection. Especially, not only...
MicroRNAs (miRNAs) are a class of ~22 nt non-coding RNA molecules in metazoans capable down-regulating target gene expression by binding to the complementary sites mRNA transcripts. Many individual miRNAs implicated broad range biological pathways, but functional characterization miRNA clusters concert is limited. Here, we report that miR-959–962 cluster (miR-959/960/961/962) can weaken Drosophila immune response bacterial infection evidenced reduced antimicrobial peptide Drosomycin (Drs)...
Avoiding excessive or insufficient immune responses and maintaining homeostasis are critical for animal survival. Although many positive negative modulators involved in have been identified, little has reported to date concerning whether the long non-coding RNA (lncRNA) can regulate Drosophila immunity response. In this study, we firstly discover that overexpression of lncRNA-CR11538 inhibit expressions antimicrobial peptides Drosomycin (Drs) Metchnikowin (Mtk) vivo, thereby suppressing Toll...
Innate immunity is the first and essential line for resisting pathogens, immune intensity duration need to be strictly regulated balance excessive or insufficient response. MicroRNAs (miRNAs) are crucial regulators of response in Drosophila, yet how immune-related miRNAs remains poorly understood. Herein, we elucidated that involvement miR-317 NF-κB transcription factor Relish mediated Drosophila Imd pathway Gram-negative (G-) bacteria stimulation. Remarkably, dynamic expression profiling...