A5016143189- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Plant Virus Research Studies
- Aquaculture Nutrition and Growth
- Phytoplasmas and Hemiptera pathogens
- Studies on Chitinases and Chitosanases
- Parasite Biology and Host Interactions
- Antimicrobial Peptides and Activities
- Neurobiology and Insect Physiology Research
- Bacteriophages and microbial interactions
- Animal Virus Infections Studies
- Crustacean biology and ecology
- Physiological and biochemical adaptations
- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Medicinal Plant Pharmacodynamics Research
- Immune Response and Inflammation
- Genomics and Phylogenetic Studies
- Insect Resistance and Genetics
Beijing Graphene Institute
2025
Knoxville College
2024-2025
University of Tennessee at Knoxville
2024-2025
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2024-2025
Wuhan Prevention and Treatment Center for Occupational Diseases
2025
First Hospital of China Medical University
2025
BGI Group (China)
2025
BGI Research
2025
China Medical University
2025
Abstract Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal vesicles (ILVs) and secreted during fusion of MVEs with cell membrane. The mechanisms exosome biogenesis remain poorly explored. Here we identify that RAB31 marks controls an ESCRT-independent pathway. Active RAB31, phosphorylated by epidermal growth factor receptor (EGFR), engages flotillin proteins in lipid raft microdomains to drive EGFR entry into form ILVs, which is independent ESCRT (endosomal...
Abstract Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs dogs at both high low altitudes, including 73 generated this study, to disentangle mechanisms underlying local adaptation of mammals. Although molecular convergence is comparatively rare DNA sequence level, found convergent signature positive selection gene particularly...
Template-free enzymatic approaches are considered the most promising solution for next-generation artificial DNA synthesis. However, development of these technologies has been hampered by lack efficient enzymes specialized stepwise nucleotide addition. By combining evolutionary analysis, high-throughput mutagenesis scanning, and rational design, we identified a terminal deoxynucleotidyl transferase from Zonotrichia albicollis (ZaTdT) reshaped its catalytic cavity to better accommodate...
An epidemic of tremor disease has been a serious problem in Chinese mitten crabs, Eriocheir sinensis , China recent years. The disease-causing agent was previously considered to be rickettsia-like organism. Here, analysis the 16S rRNA gene sequence, light and electron microscopy cultivation vitro were used identify agent. Sequence found it have 98 % identity with that Spiroplasma mirum . able passed through membrane filters pores 220 nm diameter could cultivated by inoculating yolk sac...
A motile bacterium, designated strain TDA-040725-5(T), was isolated from the haemolymph of a Chinese mitten crab, Eriocheir sinensis, with tremor disease. Based on 16S rRNA gene sequence analysis, phylogenetically distinct other spiroplasmas but closely related to Spiroplasma mirum ATCC 29335(T). Cells TDA-040725-5(T) were variable in length and shape, helical motile, as determined by phase-contrast light microscopy. Examination electron microscopy revealed wall-less cells delimited single...
A novel disease of crayfish Procambarus clarkii appeared in the summer 2004 freshwater aquaculture Jiangsu province China. Light and transmission electron microscopy (TEM), molecular biological methods vitro culture were used to identify pathogen. The agent was unique having a helical morphology rotary motility as observed by phase-contrast light found haemolymph, muscles, nerves connective tissues smear method TEM. Ultra-thin sections under TEM revealed wall-free membrane microbe. could...
Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The primary allylic hydroxyl thus formed can undergo very facile replacement by a variety nucleophiles. (Hydroxymethyl)acylfulvene (MGI.114) was more toxic than precursor, acylfulvene, but less parent compound to HL 60 cells.
ABSTRACT In eukaryotes, microRNAs (miRNAs) serve as regulators of many biological processes, including virus infection. An miRNA can generally target diverse genes during virus-host interactions. However, the regulation gene expression by multiple miRNAs has not yet been extensively explored This study found that Spaztle (Spz)-Toll-Dorsal-antilipopolysaccharide factor (ALF) signaling pathway plays a very important role in antiviral immunity against invasion white spot syndrome (WSSV) shrimp...
Chlorine disinfectants have been widely used in the poultry supply chain but this exposure can also result development of bacterial tolerance to chlorine and is often linked antibiotic cross-resistance. The objectives study were investigate sodium hypochlorite (NaClO) Salmonella isolated from chains evaluate We collected 172 isolates farms, slaughter houses retail markets China during 2019-2020. found that S. Enteritidis, Kentucky, Typhimurium constituted > 80% our isolates. Overall, 68%...
Abstract The innate immune response is the first line of host defense against viral infections, but its role in immunity SARS‐CoV‐2 remains unclear. By using immunoprecipitation coupled with mass spectroscopy, we observed that E3 ubiquitin ligase TRIM21 interacted nucleocapsid (N) protein and ubiquitinated it at Lys 375 . Upon determining topology TRIM21‐mediated polyubiquitination chain on N protein, then found led to tagging for degradation by cell proteasome. Furthermore, also proteins...
Chimeric antigen receptor (CAR) T cell therapy has transformed cancer immunotherapy. However, significant challenges limit its application beyond B cell-driven malignancies, including limited clinical efficacy, high toxicity, and complex autologous product manufacturing. Despite efforts to improve CAR outcomes, there is a growing interest in utilizing alternative immune cells develop cells. These offer several advantages, such as major histocompatibility (MHC)-independent function, tumor...