A5100439965- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Mechanisms of cancer metastasis
- Radiomics and Machine Learning in Medical Imaging
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Gastric Cancer Management and Outcomes
- Wheat and Barley Genetics and Pathology
- Extracellular vesicles in disease
- Advanced X-ray and CT Imaging
- Cancer-related gene regulation
- Colorectal Cancer Surgical Treatments
- PI3K/AKT/mTOR signaling in cancer
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Auditing, Earnings Management, Governance
- Pancreatic function and diabetes
- Cancer Mechanisms and Therapy
- Acupuncture Treatment Research Studies
- Adipose Tissue and Metabolism
- Planarian Biology and Electrostimulation
Zhengzhou University
2016-2025
Henan Cancer Hospital
2013-2025
Nanjing University of Chinese Medicine
2017-2024
Anhui Medical University
2024
University of Toronto
2024
Hospital for Sick Children
2024
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
Zhengzhou Children's Hospital
2020-2024
Institute of Information Engineering
2024
Overexpression of HOTAIR (HOX antisense intergenic RNA) is significantly correlated with tumor progression and poor prognosis in human ovarian cancer. However, the underlying mechanisms are largely unknown. In present study, we investigated roles initiation chemoresistance As our data show, overexpression promoted cell cycle (and thus proliferation) by activating wnt/β-catenin signaling pathway. Likewise, knockdown suppressed proliferation arrested at G1 phase via inhibition signaling....
This study aims to clarify the underlying mechanism for tumor suppressive function of lnc TUSC7 in chemotherapy resistance esophageal squamous cell carcinoma (ESCC).TUSC7, miR-224 and DESC1 expressions ESCC tissues cells were detected by qRT-PCR. Protein level DESC1, EGFR p-AKT observed Western blot. Overall survival was calculated using Kaplan-Meier method. Dual-luciferase reporter gene assay RIP used comfirm binding miR-224, DESC1. Cell proliferation, apoptosis, colony formation MTT, Flow...
MicroRNAs (miRNAs) have been found to play important regulatory roles in various physiological and pathological processes. MiRNAs also exhibit high stability are present at concentrations human bodily fluids. Consequently, miRNAs may represent attractive novel diagnostic biomarkers for certain clinical conditions. Recently, the capacity extracellular vesicles, including microvesicles exosomes, carry that participate cell-to-cell communication has described. In study, miRNA expression...
Abstract HOTAIR is an important carcinogenic lncRNA and involves in tumorigenesis, invasion. MiR‐34a‐5p functions as a tumour suppressor. However, the underlying mechanism of regulation especially association with miR‐34a‐5p non‐small‐cell lung cancer (NSCLC) has not been explored. Herein, we performed series vitro experiments, including viability, migration, invasion, apoptosis vivo xenograft model, identified that was remarkably elevated NSCLC cells. Enforced expression promoted migration...
Immune cell migration is a fundamental process that enables immunosurveillance and immune responses. Understanding the mechanism of not only importance to biology cells, but also has high relevance trafficking mediated physiological processes diseases such as embryogenesis, wound healing, autoimmune cancers. In addition well-known chemical concentration gradient based guiding (i.e.chemotaxis), recent studies have shown lymphocytes can respond applied physiologically relevant direct current...
MicroRNAs, non-coding 20–22 nucleotide single-stranded RNAs, result in translational repression or degradation and gene silencing of their target genes, significantly contribute to the regulation expression. In current study, we report that miR-182 expression was upregulated prostate cancer tissues four cell lines, compared benign prostatic hyperplasia normal epithelial (RWPE-1) cells. Ectopic overexpression promotes proliferation, increases invasion, G1/S cycle transition reduces early...
Computed tomography (CT) imaging is the most common modality for diagnosis and staging of gastric cancer. The aim this study was to prospectively explore ability quantitative spectral CT parameters in detection cancer its histologic types. A total 87 adenocarcinoma (43 poorly 44 well-differentiated) patients 36 with benign wall lesions (25 inflammation 11 normal), who underwent dual-phase enhanced examination, were retrospectively enrolled study. Iodine concentration (IC) normalized iodine...
Abstract Megakaryocytic leukemia 1 (MKL1) is a key transcription factor involved in non-small cell lung cancer (NSCLC) growth and metastasis. Yet, its downstream target genes, especially long non-coding RNA (lncRNA) targets, are poorly investigated. In this study, we employed lncRNA array technology to identify differentially expressed lncRNAs NSCLC cells with or without overexpression of MKL1. Candidate were further explored for their clinical significance function NSCLC. The results showed...
Immune escape of renal cell carcinoma (RCC) impacts patient survival. However, the molecular mechanism long noncoding RNA (lncRNA) small nucleolar host gene 1 (SNHG1) in RCC immune remains unclear. Quantitative real-time PCR and western blotting results revealed that expression lncRNA SNHG1 STAT3 were upregulated tissues cells miR-129-3p was downregulated. Enzyme-linked immunosorbent assay increased levels immune-related factors (interferon-γ, tumour necrosis factor α, interleukin-2)...
Background: Acute myeloid leukemia (AML) is the most common type of blood cancer in adults. Emerging evidence establishing a connection between AML and aberrant alternative splicing pre-mRNA, which may result from expression factors, mediators reactions. Material Methods: Using quantitative real-time polymerase chain reaction, we measured mRNA 7 factors belonging to serine/arginine-rich (SR) protein family, SRSF1 (SF2/ASF), SRSF2 (SC35), SRSF3 (SRp20), SRSF4 (SRp75), SRSF5 (SRp40), SRSF6...
VX680 is a potent and selective inhibitor that targets the Aurora kinase family. The p38 mitogen-activated protein (MAPK) regulates large number of cellular pathways plays an important role in regulation cell survival apoptosis. This study aimed to evaluate effect on cervical cancer cells investigate whether effects apoptosis are enhanced by ablation MAPK activation. results suggested inhibited proliferation causing G2/M phase arrest endoreduplication apoptotic was attenuated activation...
We recently demonstrated that overexpression of HOTAIR (Hox transcript antisense intergenic RNA ) was associated with tumor progression and radio‐resistance in human cervical cancer. Considering the single nucleotide polymorphism ( SNP rs920778 (C>T) could influence expression cancer predisposition other malignancies, we herein investigated association between status susceptibility a Chinese population. Using specific TaqMan PCR assay, genotyped 215 patients 430 age‐matched healthy...
Abstract Background The present study aimed to investigate the expression level, biological function, and underlying mechanism of transmembrane protein 176B (TMEM176B) in gastric cancer (GC). Methods TMEM176B was detected by quantitative real-time polymerase chain reaction (qRT-PCR) western blotting (WB). function determined various vitro assays including colony formation, 5-ethynyl-2ʹ-deoxyuridine (EdU), Transwell, flow cytometry. Bioinformatics techniques were then used elucidate signaling...