A5023456340- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Atherosclerosis and Cardiovascular Diseases
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Genetics, Aging, and Longevity in Model Organisms
- Cardiovascular Disease and Adiposity
- Single-cell and spatial transcriptomics
- Autophagy in Disease and Therapy
- Nuclear Receptors and Signaling
- Chemotherapy-induced cardiotoxicity and mitigation
- Coronary Interventions and Diagnostics
Harbin Medical University
2021-2023
Second Affiliated Hospital of Harbin Medical University
2021-2023
Heilongjiang University of Chinese Medicine
2021
Current therapies cannot completely reverse advanced atherosclerosis. High levels of amino acids, induced by Western diet, stimulate mTORC1 (mammalian target rapamycin complex 1)-autophagy defects in macrophages, accelerating atherosclerotic plaque progression. In addition, autophagy-lysosomal dysfunction contributes to necrotic core enlargement and lipid accumulation. Therefore, it is essential investigate the novel mechanism molecules acid-mTORC1-autophagy signaling macrophages patients with
Background and Aims: Acute coronary syndrome (ACS) is a group of clinical syndromes characterized by rupture or erosion atherosclerotic unstable plaques. Effective intervention for vulnerable plaques (VP) great significance to reduce adverse cardiovascular events. Methods: Fbn1 C1039G+/− mice were crossbred with LDLR −/− obtain novel model VP. After the fed high-fat diet (HFD) 12 24 weeks, pathological staining immunohistochemistry analyses employed evaluate lesions. Results: Compared...
Aim: To identify differential mRNA and ncRNA expression profiles competing endogenous RNA-associated regulatory networks during the progression of atherosclerosis (AS). Materials & methods: We systematically analyzed whole-transcriptome sequencing samples from different stages AS to evaluate their long noncoding RNA (lncRNA), circular (circRNA), miRNA profiles. Results: constructed three AS-related differentially expressed circRNAs, lncRNAs, miRNAs mRNAs. Gene Ontology Kyoto Encyclopedia...
Abstract Aging and cellular senescence are characterized by a progressive loss of physiological integrity, which could be triggered aging factors such as physiological, pathological external factors. Numerous studies have shown that gene regulatory events play crucial roles in aging, increasing the need for comprehensive repository relationships during aging. Here, we established manually curated database (AgingReG, https://bio.liclab.net/Aging-ReG/), focusing on with experimental evidence...