Abstract The central nervous system (CNS) is the most delicate in human body, with complex structure and function. It vulnerable to trauma, infection, neurodegeneration autoimmune diseases, activates immune system. An appropriate inflammatory response contributes defence against invading microbes, whereas an excessive can aggravate tissue damage. NLRP3 inflammasome was first one studied brain. Once primed activated, it completes assembly of (sensor NLRP3, adaptor ASC, effector caspase-1),...

Lactobacillus gasseri is a kind of facultative anaerobic lactic acid bacterium, and has been defined as GRAS microorganism by the US Food Drug Administration. We reported whole genome sequence L. LGZ1029. The complete LGZ1029 was 2,027,325 bp encoding 2005 genes with an average G + C content 35.06%. Based on analysis involved in antibiotic resistance, virulence factor, production harmful metabolites, we have speculated that safe. By mining tool, plnABCD operon present LGZ1029, indicating it...

Aims Epilepsy is a neurological disease occurring worldwide. Alterations in the gut microbial composition may be involved development of Epilepsy. The study aimed to investigate effects cannabidiol (CBD) on microbiota and metabolic profile epileptic rats. Materials methods results A temporal lobe epilepsy rat model was established using Li-pilocarpine. CBD increased incubation period reduced state Compared rats, M1/M2 ratio microglia group significantly decreased. expression IL-1β, IL-6,...

Lactobacillus delbrueckii is widely used in the fermentation industry. Previously, we identified DMLD-H1, a strain of subsp. bulgaricus, from traditional Chinese fermented milk. In this research, sequenced complete genome which contains 1836627 bp length with total 1947 genes and an average G + C content 49.86%. total, 103 carbohydrate metabolism are annotated KEGG database, it showed that DMLD-H1 has ability to transport lactose, glucose, fructose, mannose. Antibiotic resistance genes,...

A genome-based systematic analysis combined with phenotypic experiments was conducted to evaluate the safety properties and metabolic characteristics of Streptococcus thermophilus DMST-H2, isolated from Chinese traditional homemade yogurt in Inner Mongolia. Comparative genomic showed that DMST-H2 had a closer genetic relationship S. KLDS.3.1003 based on sequence similarities 1193 core-genes. No genes related antibiotic resistance virulence factor as well no complete biogenic amine...

In this study, a two-compartment biofilm reactor was designed for iturin A production. The consists of stirred-tank fermentor containing exclusively suspended cells and packing column where the is attached. Polyester fiber with sphere shape rough surfaces chosen as carrier in column. Batch, fed-batch, repeated-batch fermentation using Bacillus velezensis ND were studied. Compared to conventional cell fermentations, productivity batch fed-batch increased by 66.7% 63.3%, respectively. Maximum...

Here, Lacticaseibacillus rhamnosus LR-ZB1107-01, a facultative anaerobic lactic acid bacterium, was isolated from the feces of infant in Guangzhou. A systematic analysis whole genome sequence, combined with phenotype tests, undertaken to assess its safety properties and metabolic characteristics. The complete LR-ZB1107-01 2,961,421 bp 2830 genes an average G + C content 47.53%. Its genomic sequences excluded associated antibiotic resistance, harmful metabolite production, or virulence...

Dyschromatosis symmetrica hereditaria (DSH), characterized by a mixture of hyper- and hypopigmented macules on the skin, is rare pigmentary dermatosis autosomal dominant inheritance. The pathogenic gene adenosine deaminase acting RNA 1 (ADAR1), mutations in this also lead to Aicardi-Goutières syndrome type 6 (AGS 6), hereditary encephalopathy with isolated spastic paraplegia. pathomechanism ADAR1 inducing DSH has not been clarified yet. We report first case combined AGS caused homozygous...

Long non-coding RNAs (lncRNAs) larger than 200 nucleotides in length are eukaryotic RNAs, and do not encode proteins. lncRNAs considered to be important regulators many biological processes plants. In this review, the latest advances roles of rice were reviewed, functions further summarized classified. play crucial tolerance biotic abiotic stresses such as disease, drought, heat, cold, heavy metal, starvation nitrogen phosphorus rice. addition, also regulate various growth development...

Summary The fermented vegetable is a long‐history food, and the addition of probiotics in recent years has pushed it novel direction. This study explored impact direct‐vat set (DVS) starter, comprising Lactiplantibacillus plantarum MC14 Leuconostoc mesenteroides , on pickled radish (PR). DVS triggered rapid reduction pH titratable acidity, leading to lowered nitrite levels increased viable count. Textural analysis showed that springiness chewiness PR by about 55.07% 25.73%, respectively....

Polysaccharides have recently garnered interest for their possible biological activity in treating colitis. In this work, we isolated a novel polysaccharide EPS-1 from yogurt, which comprises galactose and glucose (molar ratio = 42.04:57.96) has molecular weight of 32.60 kDa on average. The structure characterization revealed that exhibits an amorphous sheet with smooth surface, comprising five distinct glycosidic bonds its repeating units. animal experiments showed might alleviate dextran...

Genetic manipulation of antagonists shows tremendous potential for improving biocontrol activity antagonists. Here, bivalent antibacterial peptide Cecropin A/PsdI gene was transformed and expressed in methylotrophic yeast, Pichia pastoris GS115. The yeast GS115/CEC-PSD showed a great ability delaying sour rot citrus fruit based on observations restrained growth geminated Geotrichum citri-aurantii spores relative to non-transformed strain. Although there no remarkable discrepancy between...

Abstract Host plants influence Cistanche germination through root secretions, and plant rhizosphere bacteria host growth. Therefore, investigating the distribution of microorganisms in these is crucial. Currently, good literature comparing soil fungi different salsa same habitat lacking. High-throughput sequencing was used here to reveal similarities differences structural composition microbial community C. from six (i.e., Halocnemum , Atriplex Kalidium Tamarix Anabasis Ceratoides ). We...

<p>Background: Genome-wide expression data of gene microarrays can be used to infer networks. At a cellular level, network provides picture the modules in which genes are densely connected, and hub genes, highly connected with other genes. A is useful identify involved same pathway, protein complex or that co-regulated. In this study, we different methods find networks ciliate Tetrahymena thermophila, describe some important properties network, such as hubs. Methodology/Principal...

Misato Mitochondrial Distribution and Morphology Regulator 1 (MSTO1) is a soluble cytoplasmic protein that regulates mitochondrial dynamics by promoting fusion. Variants in the MSTO1 gene cause rare disease characterized early-onset myopathy cerebellar ataxia, with almost 30 cases reported worldwide. Here we report case of 3-year-old boy novel heterozygous variants (c.1A>G (p.M1?) c.727G>C(p.Ala243Pro)). Sequencing data subsequent validation show two were inherited from mother father patient...