A5082864358- Extracellular vesicles in disease
- Circular RNAs in diseases
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Neurological Complications and Syndromes
- Systemic Lupus Erythematosus Research
- Acute Lymphoblastic Leukemia research
- S100 Proteins and Annexins
- Nail Diseases and Treatments
- Acute Myeloid Leukemia Research
- Moyamoya disease diagnosis and treatment
- Platelet Disorders and Treatments
- Antifungal resistance and susceptibility
- Circadian rhythm and melatonin
- Adenosine and Purinergic Signaling
- Hair Growth and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects and Toxicity Studies
- Cell Adhesion Molecules Research
- Gut microbiota and health
- T-cell and B-cell Immunology
- Immune cells in cancer
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
Second Xiangya Hospital of Central South University
2020-2025
Central South University
2020-2025
Abstract The central nervous system (CNS) is the most delicate in human body, with complex structure and function. It vulnerable to trauma, infection, neurodegeneration autoimmune diseases, activates immune system. An appropriate inflammatory response contributes defence against invading microbes, whereas an excessive can aggravate tissue damage. NLRP3 inflammasome was first one studied brain. Once primed activated, it completes assembly of (sensor NLRP3, adaptor ASC, effector caspase-1),...
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems. Immunopathology believes that abnormal T cell function and excessive production of autoantibodies by B cells are involved in multi-organ damage. Human umbilical cord mesenchymal stem (hUCMSCs) therapies have endowed with promise SLE, while the MSC-derived extracellular vesicles (MSC-EVs) was still unclear. Extracellular (EVs) subcellular components secreted a paracellular mechanism essentially...
This study investigated the management and clinical outcomes along with associated factors of posterior reversible encephalopathy syndrome (PRES) in childhood hematologic/oncologic diseases. We present data from children diseases who developed PRES after treatment primary disease chemotherapy hematopoietic stem cell transplantation (HSCT) at 3 medical centers Changsha, China 2015 to 2020, review all previously reported cases aim determining whether this neurologic manifestation affects...
To analyze the efficacy, safety, and economy of RIF compared with intravenous arsenic trioxide (ATO) for induction consolidation therapy pediatric APL.In this randomized control clinical trial (NCT02200978), children newly diagnosed APL from June 2013 to December 2017 were randomly divided into ATO groups. The groups treated or in combination all-trans retinoic acid (ARTA) conventional chemotherapeutic drugs during therapy.Ninteen patients enrolled, including eight group 11 group. After...
Extracellular vesicles (EVs) are subcellular component secreted by paracellular mechanism, which essentially a group of nanoparticles. They bilayer membrane bound containing proteins, nucleic acids and other active components. EVs gain significant status the transfer signal molecules among cells. Recent studies on regulatory effects T cells both in vitro vivo have aroused extensive interest. In most investigations, stem been reported to suppress proliferation, activation differentiation...
Abstract At present, human umbilical cord mesenchymal stem cells(hUCMSCs) have been used in the clinical treatment of systemic lupus erythematosus(SLE), However, detailed mechanism MSCs remains unclear. In this study, we investigated whether hUCMSCs derived extracellular vesicles (hUCMSC-EVs) could regulate abnormal immune responses T cells or B SLE.We isolated splenic mononuclear from MRL/lpr mice , a classical animal model SLE.PBS(Phosphate-buffered saline), 2×10 5 hUCMSCs, 25µg/ml...