A5101925605- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Estrogen and related hormone effects
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Financial Reporting and Valuation Research
- Prenatal Screening and Diagnostics
- Hedgehog Signaling Pathway Studies
- Genomics and Chromatin Dynamics
- Viral Infectious Diseases and Gene Expression in Insects
- Immune cells in cancer
- Developmental Biology and Gene Regulation
- Glutathione Transferases and Polymorphisms
- Calpain Protease Function and Regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Kruppel-like factors research
- E-Government and Public Services
- Cancer Research and Treatments
- S100 Proteins and Annexins
Taizhou People's Hospital
2022
Nantong University
2022
Xuzhou Medical College
2020-2021
Central South University
2007-2019
Second Xiangya Hospital of Central South University
2019
Xiangya Hospital Central South University
2016
Nanjing Medical University
2014-2015
Xian Yang Central Hospital
2014
Wuxi People's Hospital
2014
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2012
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, precise mechanism by which metabolic reprogramming regulates inflammatory response is unclear. Here we show that aerobic glycolysis contributes modulating inflammasome activation macrophages. PKM2-mediated promotes EIF2AK2 phosphorylation Pharmacological genetic inhibition PKM2 or attenuates NLRP3 AIM2 inflammasomes activation,...
SUZ12 is a core component of the polycomb repressive complex 2 (PRC2), which could silence gene transcription by generating trimethylation on lysine 27 residue histone H3 (H3K27Me3). Meanwhile, has been found to be overexpressed in multiple cancers; however, clinical significance and molecular mechanisms controlling gastric cancer cell proliferation metastasis are unclear. In this study, we that expression was significantly increased 64 tumor tissues compared with normal tissues....
Homeobox genes, a superfamily of evolutionarily conserved developmental function as critical master regulatory factors in controlling body plan specification and cell fate determination. Recently, substantial evidence indicates that the aberrant (HOX) genes also play key roles development cancers. Many reports have shown not only HOX gene expression is upregulated or downregulated many cancers but specific tends to differ based on tissue type. A5 (HOXA5) regulator morphogenesis...
Serine hydroxymethyltransferase 2 (SHMT2) is the first rate-limiting enzyme for serine/glycine biosynthesis and one carbon metabolism. Here, we explore underlying mechanism of how SHMT2 functions in renal cell carcinoma (RCC) initiation.In this study, expression was assessed RCC tissues. In vitro experiments were performed to investigate functional role SHMT2. The detailed mechanisms SHMT2-mediated PPAT addressed.Increased facilitated proliferation by inducing G1/S phase transition. And...
High-mobility group protein B1 (HMGB1) has important functions in cancer cell proliferation and metastasis. However, the mechanisms of HMGB1 function non-small-cell lung (NSCLC) remain unclear. This study aimed to investigate underlying mechanism HMGB1-dependent tumor NSCLC Firstly, we found high expression showed that HMBG1 promoted proliferation, migration, invasion cells. could bind SNAI1 promoter activate SNAI1. In addition, transcriptionally regulate lncRNA RSF1-IT2. RSF1-IT2 was as...
Abstract Background Aneuploidy is the most frequent cause of early-embryo abortion. Any defect in chromosome segregation would fail to satisfy spindle assembly checkpoint (SAC) during mitosis, halting metaphase and causing aneuploidy. The mitotic complex (MCC), comprising MAD1, MAD2, Cdc20, BUBR1 BUB3, plays a vital role SAC activation. Studies have confirmed that overexpression MAD2 can facilitate correct embryo stability. Research also proves miR-125b negatively regulates MAD1 expression...
Hepatobiliary cystadenoma is a rare tumor which has malignant potential.The clinical symptoms of hepatobiliary were non-specific.The features computed tomography (CT) and magnetic resonance imaging (MRI) helpful for the diagnosis this disease.The data 4 patients with who admitted to second People's Hospital Wuxi from February 2010 2013 retrospectively analyzed.Cystic lesions,divisions nodules on wall are CT MRI cystadenoma.Enhanced important preoperative cystadenoma. Key words:...
Extracellular vesicles (EVs) are subcellular component secreted by paracellular mechanism, which essentially a group of nanoparticles. They bilayer membrane bound containing proteins, nucleic acids and other active components. EVs gain significant status the transfer signal molecules among cells. Recent studies on regulatory effects T cells both in vitro vivo have aroused extensive interest. In most investigations, stem been reported to suppress proliferation, activation differentiation...