A5100423858- Microtubule and mitosis dynamics
- Endoplasmic Reticulum Stress and Disease
- Hippo pathway signaling and YAP/TAZ
- melanin and skin pigmentation
- Plant Pathogens and Fungal Diseases
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Photosynthetic Processes and Mechanisms
- Cellular transport and secretion
- RNA regulation and disease
- Pancreatic function and diabetes
- Olfactory and Sensory Function Studies
- Cellular Mechanics and Interactions
- Biotin and Related Studies
- Mitochondrial Function and Pathology
- Zebrafish Biomedical Research Applications
- Plant-Microbe Interactions and Immunity
- Biochemical Analysis and Sensing Techniques
- Plant Disease Management Techniques
- Proteoglycans and glycosaminoglycans research
- Protist diversity and phylogeny
- Nematode management and characterization studies
- Pharmacological Effects of Natural Compounds
- Skin and Cellular Biology Research
- Aldose Reductase and Taurine
University of Southern California
2025
Gansu Agricultural University
2022-2024
University of Arizona
2024
John Wiley & Sons (United States)
2018-2023
Jinan University
2023
Hudson Institute
2018-2023
Chongqing Three Gorges Academy of Agricultural Sciences
2023
Liechtenstein Institute
2023
University of Iowa
2021-2023
Southern Medical University
2021-2023
The metabolic sensor AMP-activated protein kinase (AMPK) regulates several transport proteins, potentially coupling activity to cellular stress and energy levels. creatine transporter (CRT; SLC6A8) mediates uptake into cell types, including kidney epithelial cells, where it has been proposed that CRT is important for reclamation of filtered creatine, a process critical total body homeostasis. Creatine phosphocreatine provide an intracellular, high-energy phosphate-buffering system essential...
Objective Individuals with Parkinson disease are more likely to develop melanoma, and melanoma patients reciprocally at higher risk of developing disease. Melanoma is strongly tied red hair/fair skin, a phenotype loss‐of‐function polymorphisms in the MC1R (melanocortin 1 receptor) gene. Loss‐of‐function variants have also been linked increased The present study investigate role dopaminergic neurons vivo. Methods Genetic pharmacological approaches were employed manipulate MC1R, nigrostriatal...
Abstract Hippo signaling functions to limit cellular growth, but the aberrant nuclear accumulation of its downstream YAP1 leads carcinogenesis. YAP1/TEAD complex activates oncogenic transcription, such as CTGF and c-Myc. How is protected in cytoplasm from ubiquitin-mediated degradation remains elusive. In this study, a member Angiomotin (Motin) family, AMOTL1 (Angiomotin Like 1), was screened out only one promote by several clinical cohorts, which further confirmed functional assays. The...
Abstract Colorectal cancer (CRC) is one of the most common cancers worldwide. The tumor microenvironment exerts crucial effects in driving CRC progression. Cancer‐associated fibroblasts (CAFs) serve as important components promoting This study aimed to elucidate novel molecular mechanisms CAF‐secreted insulin‐like growth factor (IGF) 2 colorectal carcinogenesis. Our results indicated that IGF2 was a prominent upregulated CAFs compared with normal fibroblasts. CAF‐derived conditioned media...
A series of 5-substituted-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole derivatives were synthesized by nucleophilic substitution reaction 5-hydroxy-2-chloromethyl -4H-pyran-4-one with 5-substituted-3-mercapto-4-amino-1,2,4-triazole, and their inhibitory effects on mushroom tyrosinase evaluated. The results indicated that most the compounds exhibited significant activity. Specifically, 5-(4-chlorophenyl)-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole (6j)...
Lung cancer is the leading cause of cancer-related death worldwide. The development epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immune checkpoint (ICIs) has brought favorable survival benefits to patients with non-small-cell lung (NSCLC); unfortunately, acquired drug resistance remains a major barrier treatment NSCLC. Recent studies have demonstrated that transcriptional co-activator PDZ-binding motif (TAZ, also called WWTR1) induces tumor evasion by directly...
Interferon (IFN)-stimulated genes (ISGs) play crucial roles in the antiviral immune response; however, IFNs also induce negative regulators that attenuate response. Here, we show both viral and bacterial invasion downregulate Nuclear Dbf2-related kinase 1 (NDR1) expression via type I IFN signaling pathway. NDR1 promotes virus-induced production of IFN, proinflammatory cytokines ISGs a kinase-independent manner. deficiency renders mice more susceptible to infections. Mechanistically, enhances...
Aurora kinases are highly conserved proteins with important roles in mitosis. Metazoans contain two kinases, A and B, which contribute distinct functions at the spindle poles equatorial region respectively. It is not currently known whether specialized of arose after their duplication animal cells or were already present ancestral kinase. We show that Dictyostelium discoideum contains a single kinase, DdAurora, displays characteristics both B. Like A, DdAurora has an extended N-terminal...
Abstract We previously reported that three point mutations in SASH 1 and mutated promote melanocyte migration dyschromatosis universalis hereditaria ( DUH ) a novel p53/ POMC /Gαs/ autoregulatory positive feedback loop is regulated by to induce pathological hyperpigmentation phenotype. However, the underlying mechanism of molecular regulation cause this disorder still remains unclear. In study, we aimed investigate undergirding disorder. Our results revealed binds with MAP 2K2 induced p53‐ ‐...
Background Ethanol (EtOH) exposure during pregnancy may result in fetal alcohol spectrum disorders ( FASD ). One of the most deleterious consequences EtOH is neuronal loss developing brain. Previously, we showed that induced neuroapoptosis brain postnatal day 4 PD 4) mice but not 12 mice. This differential susceptibility from an insufficient cellular stress response system such as unfolded protein (also known endoplasmic reticulum [ ER ] stress) In this study, compared effect on and...
Renal fibrosis features exaggerated inflammation, extracellular matrix (ECM) deposition, and peritubular capillary loss. We previously showed that IL-10 stimulates high–molecular weight hyaluronan (HMW-HA) expression by fibroblasts, we hypothesize HMW-HA attenuates renal reducing inflammation ECM remodeling. studied the effects of overexpression on HA production scarring in mouse models unilateral ureteral obstruction (UUO) ischemia/reperfusion (I/R) to investigate whether antifibrotic are...
Context Saposhnikovia divaricata (Turcz.) Schischk (Apiaceae) (SD) has various pharmacological activities, but its effects on type I allergy (TIA) have not been comprehensively studied.Objective This study evaluates the treatment and molecular mechanisms of SD against TIA.Materials methods The effective components action targets were screened using TCMSP database, allergy-related predicted GeneCards OMIM database. obtained target intersections imported into David database for GO analysis,...
Endoplasmic reticulum stress is associated with insulin resistance and the development of nonalcoholic fatty liver disease. Deficiency endoplasmic response T-cell death–associated gene 51 (TDAG51) (<i>TDAG51</i><sup>−/−</sup>) in mice promotes high-fat diet (HFD)-induced obesity, liver, hepatic resistance. However, whether this effect due specifically to TDAG51 deficiency unknown. Here, we report that protein levels are consistently reduced multiple mouse models steatosis injury as well...
Abstract Alcohol exposure has detrimental effects on both the developing and mature brain. Endoplasmic reticulum (ER) stress is one of mechanisms that contributes to alcohol‐induced neuronal damages. Mesencephalic astrocyte‐derived neurotrophic factor (MANF) an ER stress‐responsive protein neuroprotective in multiple injury neurodegenerative disease models. MANF deficiency been shown exacerbate neurodegeneration. However, it unknown whether supplement sufficient protect against alcohol...
Lanzhou Lily(Lilium davidii) var. unicolor, which is also known as sweet lily in China, used a type of food. This distributed narrow regions, propagates asexually, cultivates perennially, and commonly serious consecutive replant problems (CRPs). Soil fumigation to control soil-borne disease alleviate crops' However, due the improper application, it common cause chemical hazard crops. In this study, we designed two-factor experiment explore bacterial fungal community structure some specific...