A5060943396- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Phytochemistry and Biological Activities
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical Synthesis and Reactions
- Systemic Lupus Erythematosus Research
- Chemical Synthesis and Analysis
- COVID-19 Clinical Research Studies
- Synthesis and biological activity
- Cancer Cells and Metastasis
- Essential Oils and Antimicrobial Activity
- COVID-19 diagnosis using AI
- Nanoparticle-Based Drug Delivery
- Proteoglycans and glycosaminoglycans research
- Sesquiterpenes and Asteraceae Studies
- Biochemical Analysis and Sensing Techniques
- Autoimmune Bullous Skin Diseases
- Seaweed-derived Bioactive Compounds
- Traditional Chinese Medicine Analysis
- Synthesis of heterocyclic compounds
Hunan University
2019-2025
Hunan First Normal University
2020-2025
State Key Laboratory of Chemobiosensing and Chemometrics
2019-2025
Hunan University of Science and Technology
2024
Jiaxing University
2024
Jinan University
2024
Zhuhai People's Hospital
2024
Guangdong Medical College
2021-2022
Xiangtan University
2020
Shandong University of Traditional Chinese Medicine
2019-2020
Functional group substituted 1-naphthylamines, especially N-methylated ones, play important roles in numerous chemical and biological processes. However, these compounds' general step-economic syntheses are highly limited, which seriously restricts efforts to improve the properties develop new functions for this kind of compound. In report, we describe development an efficient, convenient, method synthesis valuable functionalized 1-naphthylamines directly from readily available terminal...
Amide and alkene moieties are frequently found in natural products privileged structures pharmaceuticals agrochemicals. Moreover, vinyl sulfoxonium ylide can be converted into a broad range of high-value compounds, thus they have been widely employed organic synthesis. However, the synthesis alkene-substituted amide-sulfoxonium ylides via intermolecular hydrocarbonation alkynes remains underexplored. This study describes development high-throughput approach to provide diverse functionalized...
An alternative thioesterification reaction via copper-catalyzed oxidative coupling of readily available aroylhydrazides with disulfides is developed, in which expulsion N2 overcomes the activation barrier between carboxylic acid derivatives and products. The produces various thioesters good to excellent yields functional group tolerance. In reaction, stable easily are used as acyl sources relatively odorless S sources. Mechanistic investigations demonstrate that copper salt oxidant...
A series of 5-substituted-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole derivatives were synthesized by nucleophilic substitution reaction 5-hydroxy-2-chloromethyl -4H-pyran-4-one with 5-substituted-3-mercapto-4-amino-1,2,4-triazole, and their inhibitory effects on mushroom tyrosinase evaluated. The results indicated that most the compounds exhibited significant activity. Specifically, 5-(4-chlorophenyl)-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole (6j)...
We prepared octreotide (OCT)-modified curcumin plus docetaxel micelles to enhance active targeting and inhibit tumor metastasis by destroying vasculogenic mimicry (VM) channels. Soluplus was applied as an amphiphilic material form via film dispersion. The cytotoxic effects, cellular targeting, inhibitory effects on were systematically evaluated in vitro using A549 cells, vivo antitumor xenograft tumor-bearing mice. In assays indicated that the OCT-modified showed robust cytotoxicity cells...
Selective condensation/bicycloaromatization of two different arylalkynes is firstly developed under ligand-free copper( i )-catalysis, which allows the direct synthesis C–N axial biaryl compounds in high yields with excellent selectivity and functional group tolerance.
In this work, the annulation of acyl nitrene with alkynes is reported under photoredox/iron dual-catalysis for synthesis a series isoquninalin-2-ones. The reaction featured high regioselectivity and good generality. particular, resulting isoquinalin-2-ones could be structurally elaborated into several biologically interesting scaffolds. Mechanism investigation suggests that was ascribed to formal [4 + 2] cyclization. It believed represents an initial example preparing isoquinolin-1-ones from...
Comprehensive Summary The activation of inert chemical bonds is an exciting area research in chemistry because it enables the direct utilization readily available starting materials and promotes atom‐ step‐economic synthesis. Undoubtedly, selectively activating transforming multiple even more intriguing demanding task synthetic chemistry. However, due to its inherent complexity extreme challenges, this endeavour rarely accomplished. We report a copper‐mediated complete cleavage selective...
The cyclization-coupling reaction of 2-bromoaryl ketones and terminal alkynes is first realized by copper catalysis, which produces polyfunctional naphthyl aryl ethers in moderate to excellent yields with broad substrate scope good functional group tolerance. This proceeds via 6-endo-dig cyclization C(sp2)-O coupling using green H2O as the unique solvent 5-bromopyrimidin-2-amine critical additive. Mechanistically, a Cu(III)-acetylide probably key intermediate, allows exclusive selectivity.
A copper(I)-catalyzed tandem reaction of 2-bromoaryl ketones, terminal alkynes, and CH3CN is developed, which combines N atom transfer three-component [3 + 2 1] cyclization, efficiently produces densely functionalized isoquinolines in a facile, highly selective, general manner. In the reaction, formation aromatic C–N bonds along with complete triple bond cleavage first realized; Cu(III)-acetylide species might serve as intermediates, allow selective 6-endo-dig cyclization.