A5069701929- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Fluorine in Organic Chemistry
- CO2 Reduction Techniques and Catalysts
- Carbon dioxide utilization in catalysis
- Cyclopropane Reaction Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Molecular Sensors and Ion Detection
- Organoboron and organosilicon chemistry
- Chemical Synthesis and Analysis
- Hydrogels: synthesis, properties, applications
- Organic Chemistry Cycloaddition Reactions
- Plant-based Medicinal Research
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Synthesis and Reactions of Organic Compounds
- Chemical Synthesis and Reactions
- Per- and polyfluoroalkyl substances research
- Phosphorus compounds and reactions
- Oxidative Organic Chemistry Reactions
Henan University of Technology
2025
Hunan University
2025
State Key Laboratory of Chemobiosensing and Chemometrics
2025
Guangxi University
2024
Nanjing Agricultural University
2024
Columbia University
2021-2023
Beijing Institute of Technology
2016-2023
Institut Català d'Investigació Química
2016-2019
Universitat Rovira i Virgili
2018
Pharmaron (United Kingdom)
2016
Triplet ketone sensitizers are of central importance within the realm photochemical transformations. Although radical-type character triplet excited states diaryl ketones suggests viability for triggering hydrogen-atom transfer (HAT) and single-electron (SET) processes, among others, their use as multifaceted catalysts in C–C bond-formation via sp3 C–H functionalization alkane feedstocks still remains rather unexplored. Herein, we unlock a modular platform forging C(sp3)–C(sp2) C(sp3)–C(sp3)...
Give it a tweak: A novel oxidizing directing group was developed for rhodium(III)-catalyzed CH functionalization of N-phenoxyacetamides with alkynes. small change in the reaction conditions leads to either ortho-hydroxyphenyl-substituted enamides or cyclization deliver benzofurans high selectivity (see scheme; Cp*=C5 Me5 ).
A redox-neutral intermolecular dicarbofunctionalization of styrenes with CO2 at atmospheric pressure and carbon-centered radicals is described. This mild protocol results in multiple C-C bond-forming reactions from simple precursors the absence stoichiometric reductants, thus exploiting a previously unrecognized opportunity that complements existing catalytic carboxylation events.
By using an oxidizing directing group, a mild, efficient Rh(III) catalyzed C–H olefination reaction between N-phenoxyacetamides and alkenes was developed. This provided straightforward way for the synthesis of ortho-alkenyl phenols, group is traceless in product.
A visible-light-mediated atom transfer radical cyclization of unactivated alkyl iodides is described. This protocol operates under mild conditions and exhibits high chemoselectivity profile while avoiding parasitic hydrogen pathways. Preliminary mechanistic studies challenge the perception that a canonical photoredox catalytic cycle being operative.
Trialkylamines are widely found in naturally occurring alkaloids, synthetic agrochemicals, biological probes, and especially pharmaceuticals agents preclinical candidates. Despite the recent breakthrough of catalytic alkylation dialkylamines, selective α-C(sp3)–H bond functionalization available trialkylamine scaffolds holds promise to streamline complex synthesis, accelerate drug discovery, execute late-stage pharmaceutical modification with complementary reactivity. However, canonical...
Selektiver Feinschliff: Eine neuartige oxidierende dirigierende Gruppe wurde für die Rhodium(III)-katalysierte C-H-Funktionalisierung von N-Phenoxyacetamiden mit Alkinen entwickelt. Durch geringfügige Veränderung der Reaktionsbedingungen lassen sich entweder ortho-Hydroxyphenyl-substituierte Enamide oder Benzofurane hoher Selektivität erhalten (siehe Schema; Cp*=C5Me5). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such...
Abstract A redox‐neutral intermolecular dicarbofunctionalization of styrenes with CO 2 at atmospheric pressure and carbon‐centered radicals is described. This mild protocol results in multiple C−C bond‐forming reactions from simple precursors the absence stoichiometric reductants, thus exploiting a previously unrecognized opportunity that complements existing catalytic carboxylation events.
The diversity and wide availability of trialkylamines render them ideal sources for rapid construction complex amine architectures. Herein, we report that a nickel/photoredox dual catalysis strategy affects site-selective α-arylation various trialkylamines. Our catalytic system shows exclusive N-Me selectivity with range under mild conditions, even in the context late-stage arylation pharmaceutical compounds bearing this common structural motif. Mechanistic studies indicate unconventional...
Using an oxidizing directing group, a mild RuII-catalyzed direct coupling of N-phenoxypivalamide with internal alkynes was developed, generating the benzofurans in moderate to high yields.
N-Demethylation of trialkylamines is a useful transformation, but typically requires harsh reaction conditions and stepwise procedures, as well judicious protection labile functional groups. Herein we report mild, catalytic approach for the demethylation by utilizing photoinduced nickel catalysis wherein C(sp2)–bromides serve hydrogen-atom transfer (HAT) reagents. This method achieves direct with wide group compatibility, making it highly suitable late-stage derivatization complex molecules....
Comprehensive Summary Herein, we report a photo‐induced, metal‐/additive‐free protocol for the difluoromethylation of N ‐heteroaromatics with [bis(difluoroacetoxy)iodo]benzene as reagent. The affords difluoromethylated in moderate to good yield (up 91%). transformation is compatible wide range substrates and has tolerance towards various functional groups. Moreover, synthetic value this method further demonstrated by applications gram‐scale synthesis late‐stage functionalization biologically...
Abstract A base‐catalyzed reaction that enables stereoselective 1,1‐silaboration of terminal alkynes is described. This method not only offers a new strategy to functionalize simple and readily accessible beyond 1,2‐difunctionalization, but also provides an unconventional atom‐ step‐economical approach rapidly reliably access versatile geminal silylboranes in the absence transition metals with exquisite stereoselectivity.
A base-mediated protocol that allows for the site-selective sp2 C–H silylation of azines is described. This method distinguished by its mild conditions, simplicity and excellent modulation a diverse set azines, even in context late-stage functionalization, while exhibiting orthogonal reactivity with classical reactions.
In recent years, supramolecular chirality has been greatly developed in asymmetric synthesis, chiral sensing and other research fields, but its application molecular recognition not extensively studied. this paper, L-Boc-tyrosine methoxyester phosphorus chloride salts were introduced into the framework of pillar[n]arene, a pillar[5]arene-based polymer L-TPP-P was constructed. The had stable properties could be used as solvation reagent for mandelic acid MA. molar ratio method Scatchard plot...
Abstract A mild and facile Wittig reaction between N ‐substituted maleimides aldehydes has been developed. Various synthetically valuable alkylidenesuccinimides were obtained from this one‐pot in high yields (up to 99%). The product was by simple filtration no extra purification necessary. Ethanol, an environment‐benign solvent, found be a suitable medium.
A batchwise, multigram preparation of 2-azabicyclo-[2.1.1]hexane hydrochloride (<b>1</b>·HCl) was developed, delivering a total 195 grams material. The key synthetic step involves an intramolecular displacement primary alkyl chloride with <i>tert</i>-butylsulfinamide to forge the [2.1.1]-bicyclic ring system.
Four kinds of poly( N ‐isopropylacrylamide)‐grafted silicas with different grafting ratios and the same density were prepared by atom transfer radical polymerization. The chemical groups in stationary phase was verified FTIR spectroscopy, content elements measured elemental analysis. ratio thermoresponsive chromatographic materials thermogravimetric analysis 2.36–21.10% mg/m 2 . retention behaviors evaluated separating five steroids ten hydrophobic properties compounds. With increase ratio,...
Abstract A base‐catalyzed reaction that enables stereoselective 1,1‐silaboration of terminal alkynes is described. This method not only offers a new strategy to functionalize simple and readily accessible beyond 1,2‐difunctionalization, but also provides an unconventional atom‐ step‐economical approach rapidly reliably access versatile geminal silylboranes in the absence transition metals with exquisite stereoselectivity.
A strategy for trifluoroacetylation of quinoxaline-2(1 H )-ones has been investigated.
Trialkylamines are widely found in naturally-occurring alkaloids, synthetic agrochemicals, biological probes, and especially pharmaceuticals agents pre-clinical candidates. Despite the recent breakthrough of catalytic alkylation dialkylamines, selective a-C(sp3 )–H bond functionalization available trialkylamine scaffolds holds promise to streamline complex synthesis, accelerate drug discovery execute late-stage pharmaceutical modification with complementary reactivity. However, canonical...