A5001835655- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Sulfur-Based Synthesis Techniques
- Luminescence and Fluorescent Materials
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Chemical synthesis and alkaloids
- Synthesis and Biological Activity
- Advanced Synthetic Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Advanced biosensing and bioanalysis techniques
- Synthesis of Organic Compounds
- Crystallography and molecular interactions
- Synthesis and biological activity
- Radical Photochemical Reactions
- Organoselenium and organotellurium chemistry
- Chemical Synthesis and Reactions
- Synthesis of Indole Derivatives
- Catalytic Cross-Coupling Reactions
Hunan University of Science and Technology
2016-2025
Southwest Petroleum University
2022
Chinese Academy of Sciences
2007-2020
Shanghai Institute of Organic Chemistry
2007-2020
Xiangtan University
2015-2020
Zhengzhou University
2016-2020
Ministry of Education of the People's Republic of China
2014
Fudan University
2012-2013
State Key Laboratory of Synthetic Chemistry
2012
Tongji University
2011
A DCP-mediated oxidative dual C–H selenation radical reaction of imidazoheterocycles with ethers or alkanes using selenium powder was developed.
An efficient and convenient copper-catalyzed chalcogenation of imidazoheterocycles with sulfur/selenium powder coumarinyl triflates has been described. This procedure provides a wide range structurally diverse coumarinylthio-/coumarinylseleno-substituted in good yields functional group tolerance. Biological evaluation showed that the newly synthesized compound 6d possesses significant vitro antiproliferative activities against human-derived esophageal, breast, stomach, prostate cancer cell...
Development of a facile but high-efficient small organic molecule-based photothermal therapy (PTT) in the vivo transparent window (800-900 nm) has been regarded as minimally invasive and most promising strategy for potential clinical cancer treatment. Phthalocyanine (Pc) molecules with remarkable photophysical photochemical properties well high extinction coefficients near-infrared region are highly desirable PTT, far satisfying single-component Pc-based PTT within very rarely reported....
Dual C-H sulfenylation was used to obtain 3-vulcanized imidazoheterocycles using odorless elemental sulfur under catalyst- and additive-free conditions. activation of both arylamines/arenols/indoles realized by a practical protocol in which DMSO served as solvent an internal oxidant.
A hitherto unreported catalyst-free ring expansion reaction of tetrahydroisoquinolines with o -alkynylarylaldehydes for the construction dibenzo[ b , d ]azepine skeleton is described.
An unprecedented synergistic copper- and amine-catalyzed cyclization of enynone is reported. This reaction features an efficient straightforward construction multisubstituted tetralone through amine-assisted regioselective oxygen atom transfer process stereoselective intramolecular Michael addition cyclization. Under dehydrative conditions, the synthesis tetrahydronaphthylimine derivatives with ketone group tolerance achieved, which could be challenging via traditional methods. The utility...
An effective palladium-catalyzed oxidative C-H/C-H cross-coupling of imidazopyridines with azoles using air as the oxidant has been developed. This protocol provides a straightforward and operationally simple method for synthesis 3-azolyl-imidazopyridines in moderate to good yields functional group tolerance. The biological evaluation revealed that newly synthesized compounds 3e 3h exhibit significant vitro antiproliferative activities against human-derived lung cancer cell lines compared...
Novel antitumor compounds featuring isoquinoline and indole moieties were synthesized by a silver nitrate promoted domino reaction involving intramolecular cyclization, nucleophilic addition of indole, subsequent N–N bond cleavage. The transformation from readily available starting materials into an interesting class indole-substituted isoquinolines was completed under mild conditions simple operations in moderate to good yields. activity these vitro significantly greater than that reference...
A series of 5-substituted-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole derivatives were synthesized by nucleophilic substitution reaction 5-hydroxy-2-chloromethyl -4H-pyran-4-one with 5-substituted-3-mercapto-4-amino-1,2,4-triazole, and their inhibitory effects on mushroom tyrosinase evaluated. The results indicated that most the compounds exhibited significant activity. Specifically, 5-(4-chlorophenyl)-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole (6j)...
An unprecedented silver nitrate mediated novel transformation of aromatic hydrazones into various isoquinolines has been developed. This method involves a promoted cyclization followed by N–N bond cleavage, and wide substrate scope under mild conditions.
Abstract A new fluorescent chemosensor 2,2′‐((1E,1′E)‐hydrazine‐1,2‐diylidenebis(methanylylidene))bis(4‐(1,2,2‐triphenylvinyl)phenol) TPESAA incorporated with salicylaldehyde azine motif was developed based on aggregation‐induced emission (AIE). The probe prepared from 4‐hydroxy tetraphenyl ethylene which underwent formylation followed by condensation hydrazine hydrate. It showed ratiometric fluorescence quenching behavior to Cu 2+ , could induce naked‐eye color changes colorless pale...
This study describes an iron-catalyzed divergent oxidation of styrene into β-hydroxylmethylketone and ketone under photo-irradiation. divergence is ascribed to the use with various substituents. More importantly, methanol oxidized formaldehyde in reaction serves as a C1 synthon. Mechanism investigations show that initiated by oxidative SET transfer cation radical. The pathway undergoes HAT β-hydride elimination well concerted cyclization. Particularly, several drug-like molecules, such...
Open-shell diradicaloids have been intensively investigated recently due to their attractive and unique optical, electronic magnetic properties. However, open-shell with non-planar conjugated frameworks are less studied, especially helical-shaped π systems. In this work, we synthesized tetraindeno-based singlet biradicals in a helical geometry, bridged by curved cyclobutenyl o-quinodimethane molecule. Large diradical characters extremely small singlet-triplet energy gaps, as well unusual...
ABSTRACTA small library of benzoxazine-fused isoquinolines has been synthesized under microwave irradiation (MW) via CuI-catalyzed domino reactions o-alkynyl aldehydes and amines having embedded nucleophiles. This strategy offers a operationally simple, environmentally acceptable route to synthesize in moderate good yields. All new compounds were characterized by 1H NMR, 13C infrared, high-resolution mass spectrometry techniques.KEYWORDS: Benzoxazine-fused isoquinolinescopper(I) iodidedomino...