A5100621134- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Luminescence Properties of Advanced Materials
- Electrocatalysts for Energy Conversion
- Glass properties and applications
- Catalytic C–H Functionalization Methods
- Fullerene Chemistry and Applications
- Fuel Cells and Related Materials
- Liver Disease Diagnosis and Treatment
- Sulfur-Based Synthesis Techniques
- Periodontal Regeneration and Treatments
- Advanced biosensing and bioanalysis techniques
- Synthesis and Properties of Aromatic Compounds
- Electrochemical Analysis and Applications
- Hydrogels: synthesis, properties, applications
- Photorefractive and Nonlinear Optics
- Graphene research and applications
- Nanoparticle-Based Drug Delivery
- Titanium Alloys Microstructure and Properties
- Psoriasis: Treatment and Pathogenesis
- Spondyloarthritis Studies and Treatments
- Transgenic Plants and Applications
- Supramolecular Chemistry and Complexes
Hunan University of Science and Technology
2013-2025
Ministry of Education of the People's Republic of China
2024
Anhui Medical University
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2022
First People's Hospital of Chongqing
2022
Center for Excellence in Molecular Plant Sciences
2022
Chinese Academy of Sciences
2022
Xiangtan University
2021
Xiangya Hospital Central South University
2018
Central South University
2018
Excellent wound dressings maintain a warm and moist environment, thus accelerating healing. In this study, we cross-linked gelatin hyaluronic acid with ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride in different ratios (gelatin/hyaluronic = 8:2, gelatin/hyaluronic 5:5, 2:8), explored the effects mechanisms of gelatinhyaluronic hydrogels on This was done by examining dressing properties, such as fluid uptake ability, water vapor transmission rate, rate evaporation. We further...
Gelatin (Gel), sodium alginate (SA) and hyaluronic acid (HA) based various hydrogels for biomedical applications were prepared by freezing-drying method using 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) as a crosslinker. The physical properties including morphology, water vapor transmission rate hydrophilicity investigated. result showed the Gel/SA/HA composite successfully crosslinked crosslinking agent. All with different compositions had highly homogeneous interconnected pores,...
[n]Peri-acenes ([n]PA) have attracted great interest as promising candidates for nanoelectronics and spintronics. However, the synthesis of large [n]PA (n > 4) is extremely challenging due to their intrinsic open-shell radical character high reactivity. Herein, we report successful isolation a derivative (1) peri-hexacene in crystalline form. The structure 1 unequivocally confirmed by X-ray crystallographic analysis. Its ground state, aromaticity photophysical properties are systematically...
Purpose: PB is one of the most severe complications late stage prostate cancer and negatively impacts patient quality life. A major challenge for treatment bone metastasis management efficient drug delivery to metastatic lesion. We aimed explore use aptamers as promising tools develop a targeted system PBs. Materials methods: In vivo SELEX was applied identify targeting aptamer in mouse model with Results: The (designated "PB") highest frequency mice bearing PC3 selected further analysis....
A composite hydrogel based on, by introducing, polyvinyl alcohol, sodium alginate, and hyaluronic acid was fabricated using CaCl2 as a cross-linker. The physical properties including morphology, water vapor transmission rate, hydrophilicity were investigated. All PVA/SA/HA hydrogels with different compositions had highly homogeneous interconnected pores, the morphologies of ranged from fibrous structure to irregular increasing content SA. introduction alginate enhanced capacity hydrogel;...
Novel antitumor compounds featuring isoquinoline and indole moieties were synthesized by a silver nitrate promoted domino reaction involving intramolecular cyclization, nucleophilic addition of indole, subsequent N–N bond cleavage. The transformation from readily available starting materials into an interesting class indole-substituted isoquinolines was completed under mild conditions simple operations in moderate to good yields. activity these vitro significantly greater than that reference...
Abstract The treatment of infected pressure ulcers (IUPs) requires addressing diverse microenvironments. A pressing challenge is to effectively enhance the regenerative microenvironment at different stages healing process, tailoring interventions as needed. Here, a dual enzyme mimetic and bacterial responsive self‐activating antimicrobial hydrogel designed IPUs introduced. This incorporates pH‐responsive enzyme‐active nanoplatforms (HNTs‐Fe‐Ag) encapsulated within methacrylate‐modified silk...
AbstractTo evaluate the biological safety of composite materials based on gelatin (Gel), hyaluronic acid (HA), and nano-bioactive glass (NBG), which has a potential application in tissue engineering, in-vivo properties were investigated by hemolysis behavior, micronucleus, skin irritation acute toxicity test. Scanning electron microscopy (SEM) morphology demonstrated that Gel-HA/NBG scaffolds had interconnected pores with mean diameters 50–500 μm. The test suggested scaffold, ratio 1.11%,...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), represents a significant global human health threat. The most effective way to end pandemic is through timely vaccination. In this study, receptor-binding domains (RBDs) Spike protein initial strain SARS-CoV-2 and its variants, B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617.1 (Kappa), were successfully displayed on surface Saccharomyces cerevisiae for development as vaccine...
The present assessments of potential toxicity metal ions (Al, Ni, Cr, V, and Ag) that construct the metallic biomaterials were carried out in vitro. By measurements cell alkaline phosphatase (ALP) activity reduction ability methyl tetrazolium (MTT), cytotoxicity prevalence has been investigated. Furthermore, poison erosion atoms on human tissue are discussed. Research results indicated trace Cr(VI) showed serious Ni as well V cytotoxic if ion concentration culture medium is over 100 micromol...
The in-vitro biocompatibility of degradable and bioactive composites consisting poly(lactide-co-glycolide) (PLGA), β-tricalcium phosphate (β-TCP), nature bone (NB) was investigated by culturing fibroblasts on the PLGA/β-TCP/NB substrates, cell morphology, proliferation, alkaline phosphatase (ALP) activity, von Kossa mineralization were evaluated. results showed that incorporation β-TCP NB benefited attachment cultured composite substrates spread better as compared to those pure PLGA after...
Abstract Polypropylene/Polyamide 6 (PP/PA6) blends-TiO2 nanocomposites have been prepared via melt blending PP/PA6 with TiO2 nanoparticles, which were pretreated toluene-2,4-di-isocyanate. The functionalized-TiO2 can react the terminal amino and carboxyl groups at PA6, interfacial interaction compatibility between matrix greatly improved resulted in higher tensile impact strength than that of those filled pristine or pure blends, they strong antimicrobial abilities against Bacillus subtilis,...
To evaluate the biological safety of composite materials based on poly(L-lactide-co-glycolide) (PLGA) and bioactive glass (BG), which have a potential application in tissue engineering, in-vivo properties were investigated by applying micronucleus test, acute systemic toxicity haemolytic test pyrogen measurement. The results indicated that PLGA/BG showed no genetic toxicity; there was toxicosis or death observed test. suggested composite, with index 0.281%, did not an obvious reaction. In...
Abstract A peroxide‐mediated oxidation/radical addition/cyclization cascade reaction for the construction of isoquinoline skeleton is reported. The mild metal‐free promoted conditions this allowed us to synthesize a library aromatic heterocycle‐substituted isoquinolines with broad substrate scope, good functional group tolerance, and high atom economy in moderate yields. radical intermediate system was captured by TEMPO confirmed mass spectrometry (TOF‐MS). Further In vitro antiproliferative...
Duhuo Jisheng Decoction (DHJSD) is an ancient compound widely used in the treatment of ankylosing spondylitis (AS). However, its efficacy controversial, and mechanism action not clear enough. Using meta-analysis network pharmacology, our study evaluated clinical DHJSD AS explored mechanisms action.We searched medical databases, including Embase, PubMed, China National Knowledge Infrastructure Wanfang, Chinese Scientific Journal Database, to identify studies that met inclusion criteria....