A5100344791- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Sulfur Compounds in Biology
- Luminescence and Fluorescent Materials
- Catalytic C–H Functionalization Methods
- Electrochemical sensors and biosensors
- Sulfur-Based Synthesis Techniques
- Luminescence Properties of Advanced Materials
- Epigenetics and DNA Methylation
- Glass properties and applications
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Analytical Chemistry and Chromatography
- Photochemistry and Electron Transfer Studies
- Nanoplatforms for cancer theranostics
- Protein Interaction Studies and Fluorescence Analysis
- Biosensors and Analytical Detection
- Click Chemistry and Applications
- Molecular Junctions and Nanostructures
- Radiation Detection and Scintillator Technologies
- Molecular spectroscopy and chirality
- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Advanced Biosensing Techniques and Applications
- Cyclopropane Reaction Mechanisms
Harbin University
2025
Ministry of Education of the People's Republic of China
2024
Hunan University of Arts and Science
2015-2024
Nankai University
2021-2024
State Key Laboratory of Medicinal Chemical Biology
2023-2024
Tianjin Medical University
2023-2024
Tianjin Medical University Eye Hospital
2023-2024
George Washington University
2023
Tianjin University
2021-2022
Hebei University of Engineering
2017-2021
The possibility that membrane fusion events in the postsynaptic cell may be required for change synaptic strength resulting from long-term potentiation (LTP) was examined. Introducing substances into block at a number of different steps reduced LTP. SNAP, protein promotes fusion, cells enhanced transmission, and this enhancement significantly less when generated synapses expressed Thus, events, which could involved either retrograde signaling or regulating receptor function both, contribute to
Although self-assembly has emerged as an effective tool for fabricating biomaterials, achieving precise control over the morphologies and functionalities of resultant assemblies remains ongoing challenge. Inspired by copper peptide naturally present in human plasma, this study, we designed a synthetic precursor, FcGH. FcGH can self-assemble via two distinct pathways: spontaneous Cu
Derivatives of the azoalkane 2,3-diazabicyclo[2,2,2]oct-2-ene (1a) with bridgehead 1,4-dialkyl (1b), 1,4-dichloro (1c), 1-hydroxymethyl (1d), 1-aminomethyl (1e), and 1-ammoniummethyl (1f) substituents form host−guest inclusion complexes β-cyclodextrin. They were employed as probes to assess substituent effects on kinetics thermodynamics this complexation by using time-resolved steady-state fluorimetry, UV spectrophotometry, induced circular dichroism (ICD) measurements, 1H NMR spectroscopy....
The stoichiometries and binding constants of the host−guest complexes between bicyclic azoalkanes 1−6 α-, β-, γ-cyclodextrins (CDs) induced circular dichroism (ICD) were analyzed. Assisted by proximity relationships obtained from 2D ROESY NMR spectra, signs intensities ICD spectra are interpreted in terms solution structures (co-conformations) CD complexes. assignments based on orientation-intensity rules Harata Kodaka, which relate to relative orientation electric dipole transition moment...
The exploration of highly efficient visible-light-driven photocatalysts for dye degradation has received great concerns in wastewater treatment. Here, molybdenum disulfide (MoS 2 ) and cadmium sulfide–manganese (CdS-Mn) were sequentially assembled onto titanium dioxide (TiO nanotube by a simple hydrothermal method coupled with successive ionic layer adsorption reaction. A zinc sulfide (ZnS) was introduced as potential barrier performance improvement; the resultant material exhibits prominent...
In the general population, acute myocardial infarction (AMI) represents a significant cause of mortality. This study is aimed at identifying novel diagnostic biomarkers to aid in treating and diagnosing AMI.The Gene Expression Omnibus (GEO) database was explored extract two microarray datasets, GSE66360 GSE48060, which were subsequently merged into single cohort. Both AMI control samples analyzed for differentially expressed genes (DEGs), subjected weighed gene coexpression network analysis...
We reported the synthesis of a tris(triazolylmethyl)amine (TTA)-bridged organosilane, functioning as Cu(I)-stabilizing ligands, and installation this building block into backbone mesoporous organosilica nanoparticles (TTASi) by sol–gel way. Upon coordinating with Cu(I), CuI-TTASi, restricted metal active center inside pore, functions molecular-sieve-typed nanoreactor to efficiently perform Cu(I)-catalyzed alkyne–azide cycloaddition (CuAAC) reactions on small-molecule substrates but fails...
Cancer immunotherapies based on cytotoxic CD8+ T lymphocytes (CTLs) are highly promising for cancer treatment. The specific interaction between T-cell receptors and peptide-MHC-I complexes (pMHC-I) cell membranes critically determines their therapeutic outcomes. However, the lack of appropriate endogenous antigens MHC-I presentation disables tumor recognition by CTLs. By devising three antigen-loaded self-assembling peptides pY-K(Ag)-ERGD, pY-K(Ag)-E, Y-K(Ag)-ERGD to noncovalently generate...
The noncovalent interactions in host–guest complexes of α-cyclodextrin (α-CD) with a series benzoic acid derivatives (RBA) were investigated by electrospray ionization tandem mass spectrometry and density functional theory (DFT) calculations. 1:1 stoichiometry the anionic was unequivocally confirmed their mass-to-charge ratios (m/z) isotope patterns. Collision-induced dissociation experiments revealed exclusive fragmentation into [α-CD]− neutral RBA afforded gas-phase kinetic stability trend...
A new and simple fluorescent probe bearing 7-nitrobenz-2-oxa-1,3-diazole N,N-bis(thiophen-2-ylmethyl)ethane-1,2-diamine was developed as a chemosensor with high selectivity sensitivity toward Hg2+ over other cations tested. The signaling is due to the coordination of S N atoms Hg2+. Upon addition 30 equivalents Hg2+, 45-fold increase in fluorescence emission intensity observed. Moreover, further successfully used image MCF-7 cells.