A5101992945- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Animal Nutrition and Physiology
- Food Quality and Safety Studies
- Probiotics and Fermented Foods
- Fermentation and Sensory Analysis
- Protein Hydrolysis and Bioactive Peptides
- Asymmetric Hydrogenation and Catalysis
- Surface Chemistry and Catalysis
- Catalytic C–H Functionalization Methods
- Biochemical effects in animals
- ZnO doping and properties
- Meat and Animal Product Quality
- GABA and Rice Research
- Cyclopropane Reaction Mechanisms
- Biochemical Analysis and Sensing Techniques
- melanin and skin pigmentation
- MXene and MAX Phase Materials
- Receptor Mechanisms and Signaling
- Conducting polymers and applications
- Sulfur-Based Synthesis Techniques
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Estrogen and related hormone effects
- Catalysis for Biomass Conversion
East China Normal University
2021-2025
Shanghai Normal University
2025
Fujian Academy of Agricultural Sciences
2019-2025
Nanchang University
2020-2025
State Key Laboratory of Food Science and Technology
2020-2025
State Key Laboratory of Chemical Engineering
2025
Green Chemistry
2025
Hainan University
2020-2025
Jilin University
2023-2024
Sichuan University
2024
A series of MnI complexes containing lutidine-based chiral pincer ligands with modular and tunable structures has been developed. The complex shows unprecedentedly high activities (up to 9800 TON; TON=turnover number), broad substrate scope (81 examples), good functional-group tolerance, excellent enantioselectivities (85-98 % ee) in the hydrogenation various ketones. These aspects are rare earth-abundant metal catalyzed hydrogenations. utility protocol have demonstrated asymmetric synthesis...
Activation of the serine-threonine kinase Akt promotes survival and proliferation various cancers. Hypoxia resistance tumor cells to specific therapies. We therefore explored a possible link between hypoxia activity. found that was prolyl-hydroxylated by oxygen-dependent hydroxylase EglN1. The von Hippel-Lindau protein (pVHL) bound directly hydroxylated inhibited In lacking oxygen or functional pVHL, activated promote cell tumorigenesis. also identified cancer-associated mutations impair...
Abstract A Mn‐catalyzed diastereo‐ and enantioselective hydrogenation of α‐substituted β‐ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti ‐α‐Substituted β‐hydroxy amides, which are useful building blocks synthesis bioactive molecules chiral drugs, were prepared in high yields with excellent selectivity (up to >99 % dr ee ) unprecedentedly activity (TON up 10000). The origin stereoselectivity was clarified by DFT calculations.
A facile approach for the synthesis of enantiopure γ-amino nitriles by copper-catalyzed aminocyanation arylcyclopropanes is disclosed, which undergoes highly enantioselective ring-opening reaction cyclopropanes. The strategy utilizes N-fluorobenzenesulfonimide as nucleophilic nitrogen source well oxidant and trimethylsilyl cyanide other nucleophile, it probably operates via a key radical cation intermediate. This provides an efficient platform asymmetric 1,3-difunctionalization
The repair of mandibular defects is a challenging clinical problem, and associated infections often hinder the treatment, leading to failure in bone regeneration. Herein, multifunctional platform designed against shortages existing therapies for infected deficiency. 2D Ti
Abstract A series of Mn I complexes containing lutidine‐based chiral pincer ligands with modular and tunable structures has been developed. The complex shows unprecedentedly high activities (up to 9800 TON; TON=turnover number), broad substrate scope (81 examples), good functional‐group tolerance, excellent enantioselectivities (85–98 % ee ) in the hydrogenation various ketones. These aspects are rare earth‐abundant metal catalyzed hydrogenations. utility protocol have demonstrated...
Photoredox/nickel-catalyzed enantioconvergent acyl cross-coupling of carboxylic derivatives with racemic secondary organotrifluoroborate was developed for the synthesis an enolizable chiral α-aryl ketone under mild neutral conditions. Moderate to high yields and good enantioselectivities were achieved.
DETQ, an allosteric potentiator of the dopamine D1 receptor, was tested in therapeutic models that were known to respond agonists. Because a species difference affinity for all rodent experiments used transgenic mice expressing human receptor (hD1 mice). When given alone, DETQ reversed locomotor depression caused by low dose reserpine. also acted synergistically with L-DOPA reverse strong hypokinesia seen higher These results indicate potential as both monotherapy and adjunct treatment...
Various classes of plant pathogenesis-related (PR) proteins have been identified in the past several decades. PR-Q, a member PR3 family encoding chitinases, has played an important role regulating resistance and preventing pathogen infection. In this paper, we functionally characterized NtPR-Q tobacco plants found that overexpression Yunyan87 resulted higher to R. solanacearum inoculation. Surprisingly, led activation many defense-related genes, such as SA-responsive genes NtPR1a/c, NtPR2...
Heat stress (HS) is a critical factor affecting the health and performance of poultry. This study investigated effects varying durations HS on antioxidant capacity intestinal damage in Jinding ducks. The ducks were exposed to an environment at 40°C for 1 h, 3 6 12 h simulate conditions. impact was assessed by measuring expression small heat shock proteins, inflammatory factors, digestive enzyme activity, permeability, pathomorphological changes jejunum. results showed that with prolonged HS,...
A new and simple fluorescent probe bearing 7-nitrobenz-2-oxa-1,3-diazole N,N-bis(thiophen-2-ylmethyl)ethane-1,2-diamine was developed as a chemosensor with high selectivity sensitivity toward Hg2+ over other cations tested. The signaling is due to the coordination of S N atoms Hg2+. Upon addition 30 equivalents Hg2+, 45-fold increase in fluorescence emission intensity observed. Moreover, further successfully used image MCF-7 cells.
Grape seed proanthocyanidin (GSP), a major polyphenol in grape seed, has several remarkable physiological activities beneficial to human health. However, the hydrophilicity of GSP hampers its cellular absorption and thus limits bio-efficiency vivo. In order enhance lipophilicity for improved bio-efficiency, lipophilic (LGSP) was synthesized by enzymatic esterification GSP. The anti-inflammatory activity LGSP evaluated lipopolysaccharides-stimulated RAW 264.7 cells vitro zebrafish...
Abstract A Mn‐catalyzed diastereo‐ and enantioselective hydrogenation of α‐substituted β‐ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti ‐α‐Substituted β‐hydroxy amides, which are useful building blocks synthesis bioactive molecules chiral drugs, were prepared in high yields with excellent selectivity (up to >99 % dr ee ) unprecedentedly activity (TON up 10000). The origin stereoselectivity was clarified by DFT calculations.