Abstract The rational integration of chemotherapy and hydroxyl radical (·OH)‐mediated chemodynamic therapy (CDT) holds great potential for cancer treatment. Herein, a smart biocompatible nanocatalyst based on porous core–shell cuprous oxide nanocrystals (Cu 2 O‐PEG (polyethylene glycol) NCs) is reported acid‐triggered chemo/chemodynamic synergistic therapy. in situ formed high density hydrophilic PEG outside greatly improves the stability compatibility NCs. porosity Cu NCs shows admirable...

Photodynamic therapy (PDT) as a noninvasive mode has attracted considerable attention in the field of oncotherapy. However, PDT efficacy is restricted either by tumor hypoxia environment or inherent properties photosensitizers (PSs) including bad water solution, photobleaching, and easy aggregation. Herein, we designed synthesized new two-dimensional (2D) metal–organic framework, Sm-tetrakis(4-carboxyphenyl)porphyrin (TCPP) nanosheets, assembling transition metal ions (Sm3+) PSs (TCPP), on...

Abstract Owing to the critical roles it plays for both structure and functionality, hydrogen bonding has high hopes orientated applications in hydrogen‐bonded organic frameworks (HOFs). Here this work, a hydrogen‐bonding strategy is performed adjusting functionality of heme‐like ligand meso‐tetra(carboxy‐phenyl)‐porphyrin (TCPP) with co‐former 1,3‐di(4‐pyridyl) propane (1,3‐DPP). A 3D dynamic HOF TCPP‐1,3–DPP, permanent porosity obtained. For HOF, two components form novel robust 1D porous...

Herein, a biocompatible 2D metal-organic frameworks (Cu-TCPP(Fe)) based on TCPP(M) (TCPP = tetrakis (4-carboxyphenyl) porphyrin, M Fe) and copper ion were synthesized as novel drug carrier. Sequentially, the cisplatin was loaded merge of carboxyl-rich Cu-TCPP(Fe) through forming favorable carboxyl-drug interactions. The prepared Pt/Cu-TCPP(Fe) showed highly enhanced cytotoxicity than that free in human pulmonary carcinoma A549 cells, whereas inverse inhibitory effects observed normal BEAS-2B...

Until now, ferroptotic therapeutic strategies remain simple, although ferroptosis has aroused extensive interest owing to its escape from the biocarriers of conventional modalities. Herein, we construct a photothermal (PT)- and autophagy-enhanced modality based on MnO2@HMCu2–xS nanocomposites (HMCMs) for efficient tumor ablation. The HMCMs possess PT-enhanced glutathione (GSH) depletion capability, thereby inducing via reinforced inactivation peroxidase 4 (GPX4). Thereafter, GSH-responsed...

Trifluoroacetic acid (TFA) is a ubiquitous and persistent environmental pollutant with significant human health impacts. To the best of our knowledge, no study has reported use porous organic polymers to adsorb TFA vapor. In this study, we successfully synthesized polymer (POPSP-4) that exhibits both physical chemical adsorption for efficient capture, can occur at sulfur sites. With assistance bases, capacity increases from 2.3 g·g–1 over 4 in 1 h effectively prevents escape polymer. This...

Magnetism of a complex [Fe(H2Bpz2)2(bipy-NH2)] (H2Bpz2 = dihydrobis(1-pyrazolyl)borate, bipy-NH2 4,4′-diamino-2,2′-bipyridine) has been altered from paramagnetic to spin-crossover (SCO) behavior, through protonation one amino group with CF3SO3H. Complete SCO transition, both in solid state and solution, occurs at ambient temperature.

Through a facile-operating ultrasonic force-assisted liquid exfoliation technology, the single-layered two-dimensional (2D) [Co(CNS)2(pyz)2]n (pyz = pyrazine) nanosheets, with thickness of sub-1.0 nm, have been prepared from bulk precursors. The atomically and presence abundant sulfur atoms high electronegativity arrayed on double surfaces sheets are making this kind 2D MOF (metal–organic framework) nanosheets highly sensitive to intermolecular interactions. As result, it can be well...

The currently involved two-dimensional materials (2DMs) are referred to as atomically thin-layered materials, which composed of in-plane covalent or coordinated crystalline sheets with different chemical compositions and crystal structures. However, if the supported by noncovalent intermolecular interactions, such hydrogen-bonding, van der Waals, etc., can be exfoliated into stable thin nanosheets, then category members 2DM family will expanded significantly extensively. Here we demonstrate...

Organic–inorganic hybrid perovskite materials have attracted much attention because they combine the advantages of organic and inorganic components at molecular level. both structural variability flexibility components, as well magnetic, electrical, thermal properties components. A novel one-dimensional organic–inorganic halide material [Et3NCH2Br][PbBr3] (compound 1) undergoes a high-temperature phase transition around 429.3 K, which is triggered by order–disorder change cations....

Fine tuning of the structures and properties hydrogen-bonded organic frameworks (HOFs) has been considered to be a huge challenge. Herein, we reported controlled synthesis meso-tetrakis(carboxyphenyl)porphyrin (TCPP)-based HOFs via "counterstrategy" blocking strong building units on TCPP backbones. Mediated by temperatures, both kinetically thermodynamically favored HOF products TCPP-2(DMF), TCPP-4(DMF), TCPP-6(DMF) can obtained under 120, 130, 140 °C, respectively. Results revealed that...

Phototherapy is considered a promising alternative to conventional tumor treatments due its noninvasive modality and effective therapeutic effect. However, designing photosensitizer with satisfactory effect high security remains considerable challenge. Herein, series of dimeric heptamethine cyanine photosensitizers an aromatic diphenol linker at the meso position developed improve photothermal conversion efficiency (PCE). Thanks extended conjugate system steric hindrance, screened 26NA-NIR...

Integrated multichannel response switches, characterized by their simple and compact structure, have a wide range of applications in the fields smart temperature sensors, communication devices. Starting from N,N-dimethylpropan-2-amine, this paper reports on three new perovskite materials introducing groups -OH -OMe through chemical design. All materials, namely, (DMIPA)PbBr3, (DMIPA-OH)PbBr3, (DMIPA-OMe)PbBr3, possess both enthalpic dielectric switching characteristics, with (DMIPA)PbBr3...

Ferroelectric materials have broad application prospects in photovoltaics, energy storage, information storage and other fields, it is always a challenge to obtain ferroelectric through rational molecular design. Noncentrosymmetric...

Biodegradable polymeric nanoparticles have received growing interest as one of the most promising agents for drug delivery. In present work, functional and core-crosslinked poly(ethylene glycol) with poly(ϵ-caprolactone) (PEG5k -PCL10k ) block copolymer lecithin biodegradable polymer doped polyaniline was used to assemble which were prepared targeted delivery controlled release cisplatin. The morphology determined by dynamic light scattering showed a size 83(±1) nm uniform spherical shape....

Combination therapy with multiple drugs through a multi-pronged assault as strategy to combat cisplatin resistance shows great potential in biochemical for cancer. However, inherent issues such low drug loading and the poor synergistic effects of partially limit further application combination therapy. Here, we synthesized new compound, ART-Chol, by coupling artemisinin cholesterol base material combined cyclic (Arg-Gly-Asp-d-Phe-Lys)]-poly(ethylene glycol) distearoylphosphatidylcholine...

Cisplatin is a potent antitumor drug, which widely applied in clinical cancer treatment. However, cisplatin can hardly distinguish between healthy tissue and tumor tissue, resulting serious toxic side effects. Indocyanine green (ICG) FDA-approved near-infrared (NIR) fluorescence dye has been used photothermal therapy optically mediated diagnostic, but the application of ICG limited by its concentration-dependent aggregation, poor aqueous stability vitro, lack target specificity rapid...

Organic–inorganic hybrid phase-transition materials have attracted widespread attention in energy storage and sensor applications due to their structural adaptability facile synthesis. However, increasing the temperature (Tc) effectively remains a formidable challenge. In this study, we employed strategy regulate intermolecular interactions (different types of hydrogen bonds other weak interactions), utilizing bismuth chloride as an inorganic framework azetidine, 3,3-difluoro 3-carboxyl...

[Gd(DMF)2(H2O)3Cr(CN)6]·H2O is the first lanthanide−transition metal array with a flat two-dimensional brick-wall-like molecular structure. The antiferromagnetic coupling between adjacent Gd−Cr ions leads to intralayer ferrimagnetic correlation due noncancellation of spins. long-range magnetic ordering (TN = 3.5 K) was observed for time in low-dimensional cyano-bridged 4f−3d coordination polymers. Metamagnetic behavior at 1.8 K arising from layers.