A5016714642- Pulmonary Hypertension Research and Treatments
- Aortic aneurysm repair treatments
- Advanced Combustion Engine Technologies
- Hepatocellular Carcinoma Treatment and Prognosis
- Catalytic Processes in Materials Science
- Synthesis and properties of polymers
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Flame retardant materials and properties
- Dermatologic Treatments and Research
- Single-cell and spatial transcriptomics
- Fire dynamics and safety research
- RNA modifications and cancer
- Electrospun Nanofibers in Biomedical Applications
- Catalysis and Oxidation Reactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dementia and Cognitive Impairment Research
- High-Temperature Coating Behaviors
- Adipose Tissue and Metabolism
- High Entropy Alloys Studies
- Aortic Disease and Treatment Approaches
- Occupational and environmental lung diseases
- Cardiac Fibrosis and Remodeling
- Evacuation and Crowd Dynamics
- Epoxy Resin Curing Processes
Sichuan University
2023-2025
Jichi Medical University
2024-2025
Jilin University
2024-2025
State Key Laboratory of Oral Diseases
2025
Taiyuan University of Technology
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Hunan Normal University
2022-2024
Hunan Provincial People's Hospital
2022-2024
Division of Cancer Epidemiology and Genetics
2024
Ocean University of China
2024
Abstract Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, currently used drugs cannot reverse progress. Worse still, there are still challenges to be addressed fully decipher intricated pathogenesis. Thus, specifying essential mechanisms targets in silicosis progression then exploring anti-silicosis pharmacuticals desperately needed. In this work, multi-omics atlas was constructed depict pivotal abnormalities of develop targeted agents. By...
Pulmonary hypertension (PH) is a progressive cardiopulmonary disease with high mortality rate. Although growing evidence has revealed the importance of dysregulated energetic metabolism in pathogenesis PH, underlying cellular and molecular mechanisms are not fully understood. In this study, we focused on ME1 (malic enzyme 1), key linking glycolysis to tricarboxylic acid cycle. We aimed determine role mechanistic action PH.
Abstract Bone repair is intricately correlated with vascular regeneration, especially of type H vessels. Sirtuin 1 (SIRT1) expression closely associated endothelial function and regeneration; however, the role SIRT1 in enhancing coupling vessel formation osteogenesis to promote bone needs be investigated. A co‐culture system combining human umbilical vein cells osteoblasts was constructed, a agonist used evaluate effects activity. The angiogenic osteogenic capacities were examined using...
The lack of sufficient uniform deformation ability body-centered cubic (BCC) high-entropy alloys (HEAs) is the obstacle to their applications as structural materials. Here we present a grain refinement strategy achieve excellent ductility BCC non-equal atomic ratio Ti-Zr-V-Nb-Al (TZ) alloy. elongation and yield strength fine-grained TZ alloy with size 15 µm are high ~12% 840 MPa, respectively. outstanding deformability due frequent cross-slip events abundant dislocation tangles. Grain can...
The apolipoprotein E (APOE) e4 genotype is a powerful risk factor for late-onset Alzheimer's disease (AD). In the Disease Neuroimaging Initiative (ADNI) cohort, we previously reported significant baseline structural differences in APOE carriers relative to non-carriers, involving left hippocampus more than right—a difference pronounced homozygotes heterozygotes. We now examine longitudinal effects of on hippocampal morphometry at 6-, 12- and 24-months, ADNI cohort. employed new automated...
A P/N flame-retardant TBD based on a pyrimidine ring was devised and developed by reacting 2,4,6-triaminopyrimidine, benzaldehyde, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide to create less toxic, low-smoke, mechanically improved the epoxy resin (EP). The EP modified using exhibited good transparency, which attributed outstanding compatibility of with EP. With phosphorus content only 0.65%, EP/TBD10 passed V-0 rating UL-94 test, limited oxygen index increased from 27.1% (pure EP)...
Apolipoprotein E (APOE) e4 is the major genetic risk factor for late-onset Alzheimer's disease (AD). The dose-dependent impact of this allele on hippocampal volumes has been documented, but its influence general morphology in cognitively unimpaired individuals still elusive. Capitalizing study a large number late middle aged and older adults with two, one no APOE-e4 alleles, current aims to characterize ability our automated surface-based morphometry algorithm distinguish between these three...
Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary inflammation, fibrosis and lung dysfunction. Currently, the pathophysiological process silicosis has not been well studied. Here, we defined progression as four stages unsupervised clustering analysis: normal stage, inflammatory progressive stage fibrotic stage. Specifically, in function was normal, no inflammation or detected tissue. Inflammatory showed a remarkable but mild In significant...
Pulmonary hypertension (PH) is a fatal disorder characterized by pulmonary vascular remodeling and obstruction. The phosphodiesterase 4 (PDE4) family hydrolyzes cyclic AMP (cAMP) comprised of four subtypes (PDE4A–D). Previous studies have shown the beneficial effects pan-PDE4 inhibitors in rodent PH; however, this class drugs associated with side owing to broad inhibition all PDE4 isozymes. Here, we demonstrate that PDE4B predominant PDE isozyme lungs it was upregulated human PH lung...
Purpose: PB is one of the most severe complications late stage prostate cancer and negatively impacts patient quality life. A major challenge for treatment bone metastasis management efficient drug delivery to metastatic lesion. We aimed explore use aptamers as promising tools develop a targeted system PBs. Materials methods: In vivo SELEX was applied identify targeting aptamer in mouse model with Results: The (designated "PB") highest frequency mice bearing PC3 selected further analysis....
Abstract A phosphorous/silicon/triazine‐containing flame retardant named DTD is synthesized and provides epoxy resin with enhanced retardancy mechanical properties simultaneously. The modified the content of 18.1 wt% shows excellent retardancy, manifested in limited oxygen index (LOI) value 36.6% UL‐94 V‐0 rating obtained. In cone calorimeter test, its peak heat release rate (PHRR), total (THR) average effective combustion (av‐EHC) are reduced by 43.7%, 45.0%, 38.1% compared neat resin,...
This study investigates the maximum temperature in tunnel fires under forced ventilation conditions by constructing a 1:10 scale experimental model and using numerical simulations. A dimensionless derivation of is provided for case where fire source at end excavation tunnel. correction factor prediction coefficient suggested situations when situated center The results highest FDS simulation different have good fitting performance, correlation 0.899 0.913. effect outlet distance on was...
ABSTRACT Inferior alveolar nerve lateralization (IANL) is a viable treatment option for managing severely atrophic posterior mandibles with dental implants. However, this approach frequently accompanied by postoperative neurosensory disturbance (NSD). This report described procedure bilateral IANL simultaneous implant placement using 3D printing in preoperative planning and concentrated growth factor (CGF). printed models enabled surgeons to gain detailed understanding of the underlying...
Abdominal aortic aneurysm (AAA) is a permanent expansion of the abdominal aorta that has high mortality but limited treatment options. Phosphodiesterase (PDE) 4 family members are cAMP-specific hydrolyzing enzymes and have four isoforms (PDE4A-PDE4D). Several pan-PDE4 inhibitors used clinically. However, regulation function PDE4 in AAA remain largely unknown. Herein, we showed PDE4D expression upregulated human angiotensin II-induced mouse tissues using RT-PCR, western blotting,...
Abdominal aortic aneurysm (AAA) is potentially life-threatening in aging population due to the risk of rupture and a lack optimal treatment. The roles different vascular immune cells AAA formation pathogenesis remain be future characterized. Single-cell RNA sequencing was performed on an angiotensin (Ang) II-induced mouse model AAA. Macrophages, B cells, T fibroblasts, smooth muscle endothelial were identified through bioinformatic analyses. discovery multiple subtypes macrophages, such as...
In order to develop a liquid oxygen-compatible (LOX-compatible) matrix resins for polymer-based fiber-reinforced composites, novel phosphorus-containing imidazole derivative called VAD containing multifunctional groups was synthesized and used as co-curing agent epoxy resin (EP) with simultaneous LOX-compatibility mechanical improvement. A phosphorus group introduced into the EP capture free radicals generated during pyrolysis of polymer improve LOX compatibility, trimethylene flexible...