A5100738422- Angiogenesis and VEGF in Cancer
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Tryptophan and brain disorders
- Chronic Kidney Disease and Diabetes
- Epigenetics and DNA Methylation
- Tea Polyphenols and Effects
- Respiratory Support and Mechanisms
- Retinal Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Cardiac Fibrosis and Remodeling
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related Molecular Pathways
- Metabolomics and Mass Spectrometry Studies
- Cancer Research and Treatments
- Hydrogen's biological and therapeutic effects
Changhua Christian Hospital
2019-2025
Chia Nan University of Pharmacy and Science
2014-2025
Tsinghua University
2008-2025
Center for Life Sciences
2025
Heilongjiang Provincial Hospital
2025
Kaohsiung Chang Gung Memorial Hospital
2015-2024
Chang Gung University
2015-2024
Longyan University
2022-2024
Fudan University
2022-2024
Soochow University
2024
The Internet is an important source of health information. Thus, the frequency searches may provide information regarding infectious disease activity. As example, we examined relationship between for influenza and actual occurrence. Using search queries from Yahoo! engine ( http://search.yahoo.com ) March 2004 through May 2008, counted daily unique originating in United States that contained influenza-related terms. Counts were divided by total number searches, resulting fraction was...
We tested the hypothesis that combined xenogenic (from mini-pig) adipose-derived mesenchymal stem cell (ADMSC) and ADMSC-derived exosome therapy could reduce brain-infarct zone (BIZ) enhance neurological recovery in rat after acute ischemic stroke (AIS) induced by 50-min left middle cerebral artery occlusion. Adult-male Sprague-Dawley rats (n = 60) were divided equally into group 1 (sham-control), 2 (AIS), 3 [AIS-ADMSC (1.2×106 cells)], 4 [AIS-exosome (100μg)], 5 (AIS-exosome-ADMSC). All...
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In this work, a new class of polyurethane based ionogels that can respond to external stimulus, e.g., temperature, has been synthesized. The are mechanically robust and undergo an LCST-type phase transition with no volume change upon heating accompanied by switching optical transmittance. temperature is tunable within wide range between subzero over 100 °C. Molecular dynamic simulation aided molecular design provided further mechanistic understanding. Apart from the transition, these absent...
Abstract Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, currently used drugs cannot reverse progress. Worse still, there are still challenges to be addressed fully decipher intricated pathogenesis. Thus, specifying essential mechanisms targets in silicosis progression then exploring anti-silicosis pharmacuticals desperately needed. In this work, multi-omics atlas was constructed depict pivotal abnormalities of develop targeted agents. By...
Dipeptidyl peptidase-IV (DPP-IV) is one of the main targets for blood sugar control. Some food protein-derived peptides are thought to have DPP-IV inhibitory (DPP-IVi) activity. In this study, chickpea protein hydrolysates (CPHs) obtained through Neutrase hydrolysis 60 min (CPHs-Pro-60) exhibited highest DPP-IVi activity after simulated in vitro gastrointestinal digestion was maintained at >60%. Peptide libraries established identification peptide sequences. Molecular docking verified that...
The mechanical properties of the human supraspinatus tendon (SST) are highly heterogeneous and may reflect an important adaptive response to its complex, multiaxial loading environment. However, these functional associated with a location-dependent structure composition that have not been fully elucidated. Therefore, objective this study was determine concentrations types I, II III collagen in six distinct regions SST compare changes concentration across local properties. We hypothesized...
Abstract We investigated the cardioprotective effect of melatonin (Mel) and exendin‐4 (Ex4) treatment in a rat model cardiorenal syndrome ( CRS ). Adult male SD rats (n=48) were randomly equally divided into sham control SC ), dilated cardiomyopathy DCM ) (doxorubicin 7 mg/kg i.p. every five days/4 doses), (defined as + CKD only, ‐Mel (20 mg/kg/d), ‐Ex4 (10 μg/kg/d), ‐Mel‐Ex4 groups. In vitro results showed protein expressions oxidative stress NOX ‐1/ ‐2/oxidized protein), DNA /mitochondrial...
We tested the hypothesis that combined melatonin and autologous adipose-derived mesenchymal stem cells (ADMSC) was superior to either alone against small bowel ischemia-reperfusion (SBIR) injury induced by mesenteric artery clamping for 30 min followed reperfusion 72 hr. Male adult Sprague Dawley rats (n = 50) were equally categorized into sham-operated controls SC, SBIR, SBIR-ADMSC (1.0 × 10(6) intravenous 1.0 intrajejunal injection), SBIR-melatonin (intraperitoneal 20 mg/kg at after SI...
Abstract We tested the hypothesis that melatonin (Mel) enhances exogenous mitochondria (Mito) treatment against rodent hepatic ischemia–reperfusion (IR) injury. In vitro study utilized three groups of hepatocytes (i.e. nontreatment, menadione, and menadione–melatonin treatment, 4.0 × 10 5 each), while in vivo used adult male Sprague Dawley rats (n = 40) equally divided into sham‐control (SC), IR (60‐min left‐lobe ischemia + 72‐hr reperfusion), IR‐Mel (melatonin at 30 min/6/8 hr after IR‐Mito...
Thrombospondin 1 and thrombospondin 2 (THBS1 THBS2) share similar multifunctional domains, are known to be antiangiogenic. However, the expression pattern of THBS1 THBS2 is different, specific role in different subtypes lung cancer remains largely unclear. To evaluate significance development cancer, present study performed a microarray-based systematic-analysis determine transcript levels thrombospondins their relation prognosis cancer. was general underexpressed cancer; contrast, mRNA were...
Background The purpose of this study was to examine the relationship phthalates exposure with thyroid function in pregnant women and their newborns. Methods One hundred forty-eight Taiwanese maternal infant pairs were recruited from E-Da hospital southern Taiwan between 2009 2010 for analysis. One-spot urine samples blood third trimester cord at delivery collected. Nine phthalate metabolites determined by triple quadrupole liquid chromatography tandem mass spectrometry, whereas serum used...
The treatment of adhesive capsulitis (AC) is a well-known, complicated, and long process. Recent studies have shown that pulsed radiofrequency (PRF) lesioning the suprascapular nerve (SSN) using fluoroscopy- or computed tomography-guided technique can alleviate shoulder pain. However, there are no PRF SSN in patients with AC ultrasound-guided (UG) techniques, except for 2 case reports. In this study, we compared effect physical therapy alone UG technique.Sixty were included study. Patients...
This study aimed to evaluate the impact of small-for-gestational-age (SGA) on mortality and morbidity in very-low-birth-weight (VLBW) infants.We conducted a retrospective cohort VLBW infants registered at Premature Baby Foundation Taiwan between 2007 2011. All 21 neonatal departments participated data collection, total 4636 were during period. The SGA group (n = 560) was selected from database basis birth weight below 10(th) percentile for gestational age, whereas...
Abstract We tested the hypothesis that daily melatonin treatment protects endothelial lineage and functional integrity against aging process, oxidative stress/endothelial denudation (ED), toxic environment restored blood flow in murine critical limb ischemia (CLI). In vitro study using HUVECs, vivo models (ie, CLI through left femoral artery ligation ED carotid wire injury), model of lipopolysaccharide‐induced aortic injury young (3 months old) aged (8 mice were used to elucidate effects on...
The skin is the first line of defense for human body and vulnerable to injury. Various topical or systemic diseases facilitate inflammation, when intensity duration injury exceeds ability tissue repair, fibrosis, an outcome a dysregulated tissue-repair response, begins dominate repair process. However, existing methods reducing fibrosis are insufficient cause side effects, highlighting need drugs that effectively inhibit reduce immunogenicity, apoptosis, pyroptosis. Tetrahedral framework...