A5100393551- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Hematopoietic Stem Cell Transplantation
- Osteoarthritis Treatment and Mechanisms
- Platelet Disorders and Treatments
- Heavy Metal Exposure and Toxicity
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Natural product bioactivities and synthesis
- Acute Myeloid Leukemia Research
- Blood properties and coagulation
- T-cell and B-cell Immunology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Spondyloarthritis Studies and Treatments
- Mesenchymal stem cell research
- Lipid metabolism and disorders
- Folate and B Vitamins Research
- Immunotherapy and Immune Responses
- Heavy metals in environment
- Trace Elements in Health
- Monoclonal and Polyclonal Antibodies Research
Shanghai Micro Satellite Engineering Center
2024
Guangxi Medical University
2023-2024
Shanghai Jiao Tong University
2014-2024
Anhui Medical University
2024
First Affiliated Hospital of Anhui Medical University
2024
Shanghai Ninth People's Hospital
2019-2024
Shenzhen Second People's Hospital
2021-2024
Shenzhen University
2023-2024
City of Hope
2018-2024
Beckman Research Institute
2023-2024
Abstract Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, currently used drugs cannot reverse progress. Worse still, there are still challenges to be addressed fully decipher intricated pathogenesis. Thus, specifying essential mechanisms targets in silicosis progression then exploring anti-silicosis pharmacuticals desperately needed. In this work, multi-omics atlas was constructed depict pivotal abnormalities of develop targeted agents. By...
Exposure to heavy metals alone or in combination can promote systemic inflammation. The aim of this study was investigate potential associations between multiple plasma and markers immune
Observational studies found associations between ankylosing spondylitis (AS) and iridocyclitis (IC), but the causality remained unconfirmed.
CYP4B1 belongs to the mammalian CYP4 enzyme family and is predominantly expressed in lungs of humans. It responsible for oxidative metabolism a wide range endogenous compounds xenobiotics. In this study, using data from The Cancer Genome Atlas (TCGA) project Gene Expression Omnibus (GEO) database, secondary analysis was performed explore expression profile , as well its prognostic value patients with lung adenocarcinoma (LUAD). Based on obtained results, significantly decreased discovered...
Lymphoplasmacytic lymphoma (LPL) is an incurable low-grade with no standard therapy. Nine asymptomatic patients treated a first-in-human, neoantigen DNA vaccine experienced dose limiting toxicities (primary endpoint, NCT01209871). All achieve stable disease or better, one minor response, and median time to progression of 72+ months. Post-vaccine single-cell transcriptomics reveal dichotomous antitumor responses, reduced tumor B-cells (tracked by unique B cell receptor) their survival...
Purpose: NK/T-cell neoplasms are rare, highly aggressive, and insensitive to chemotherapy. These lymphomas have a poor prognosis, with patients being vulnerable relapse. Hence, there is need for alternative treatments. The purpose of this study investigate whether anti-PD1 takes effect on NK/T cell lymphoma. Methods: expression PD-L1 in lines was investigated by flow cytometry Western blot. In vivo, overall survival median time mice bearing an line tumor assessed. Tumor-infiltrating T cells...
Osteoarthritis (OA) is a chronic joint disease characterized by the deterioration of cartilage and subchondral bone in joints. Currently, there no complete cure for OA, only treatments designed to temporarily relieve pain improve function. Compared with high cost surgical treatment, medical treatment OA more acceptable cost-effective. Rutin, as flavonoid, has been shown have anti-OA properties. We evaluated effects rutin on chondrocytes lipopolysaccharide (LPS)-induced rats induced anterior...
Abstract Background We aimed to analyse the oral health status of adolescents in Shandong province, including dental caries and gingivitis, their associated factors. Methods Adolescents aged 12–15-years province were recruited. Caries gingival assessed following World Health Organisation diagnostic criteria. Information sociodemographic, hygiene knowledge, attitudes practices collected through questionnaire. Chi-square test multivariate logistic regression analysis used investigate diseases...
Abstract Background For hypertensive patients without a history of stroke or myocardial infarction (MI), the China Stroke Primary Prevention Trial (CSPPT) demonstrated that treatment with enalapril-folic acid reduced risk primary compared enalapril alone. Whether folic therapy is an affordable and beneficial strategy for prevention in from Chinese healthcare sector perspective has not been thoroughly explored. Methods We performed cost-effectiveness analysis alongside CSPPT, which randomized...
B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that mediates the escape of tumor cells from immunosurveillance. Consequently, BTLA its ligand herpesvirus entry mediator (HVEM) are potentially immunotherapeutic targets. However, potential effects on remain incompletely unknown. Here, we show expressed across a broad range cells. The depletion or HVEM promotes cell proliferation colony formation, which reversed by overexpression in knockout In contrast, inhibits...
<title>Abstract</title> <bold>Backgroud</bold>: Acute myocardial infarction is mainly caused by a lack of blood flood in the coronary artery. Angiopoietin-like protein 2 (ANGPTL2) induces platelet activation and thrombus formation vitro through binding with immunoglobulin-like receptor B, an immunoglobulin superfamily receptor. However, mechanism which it regulates function vivo remains unclear. <bold>Methods</bold>: In this study, we investigated role ANGPTL2 during thrombosis relationship...
BackgroundHeart failure (HF) and idiopathic pulmonary fibrosis (IPF) are global public health concerns. The relationship between HF IPF is widely acknowledged. However, the interaction mechanisms these two diseases remain unclear, early diagnosis particularly difficult. Through integration of bioinformatics machine learning, our work aims to investigate common gene features, putative molecular causes, prospective diagnostic indicators HF.MethodsThe Gene Expression Omnibus (GEO) database...
Human acute myeloid leukemia (AML) is a fatal hematologic malignancy characterized with accumulation of blasts and differentiation arrest. The development AML associated serial genetic epigenetic alterations mainly occurred in hematopoietic stem progenitor cells (HSPCs), which change HSPC state at the molecular cellular levels transform them into (LSCs). LSCs play critical roles initiation, progression, relapse, need to be eradicated achieve cure clinic. Key successfully targeting fully...