A5053412071- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- COVID-19 diagnosis using AI
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Computational Drug Discovery Methods
- Gastrointestinal Tumor Research and Treatment
- Bioinformatics and Genomic Networks
- Biomarkers in Disease Mechanisms
- Topic Modeling
- Cerebrovascular and Carotid Artery Diseases
- Occupational exposure and asthma
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Inflammasome and immune disorders
- Asthma and respiratory diseases
- Bone health and treatments
- Autophagy in Disease and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Seismology and Earthquake Studies
- Microbial Natural Products and Biosynthesis
- Bone and Joint Diseases
- Thyroid Cancer Diagnosis and Treatment
- Cardiomyopathy and Myosin Studies
Harbin Medical University
2014-2024
Second Affiliated Hospital of Harbin Medical University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
China-Japan Friendship Hospital
2019-2021
Beijing University of Chinese Medicine
2019-2021
Peking Union Medical College Hospital
2021
National Clinical Research Center for Digestive Diseases
2020
Beijing Anzhen Hospital
2018
Capital Medical University
2018
East China Normal University
2014-2015
Silicosis caused by inhalation of silica particles leads to more than ten thousand new occupational exposure-related deaths yearly. Exacerbating this issue, there are currently few drugs reported effectively treat silicosis. Tetrandrine is the only drug approved for silicosis treatment in China, and despite decades use, its efficacy mechanisms action remain largely unknown. Here, study, we established mouse models investigate effectiveness tetrandrine early late therapeutic administration....
Abstract Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, currently used drugs cannot reverse progress. Worse still, there are still challenges to be addressed fully decipher intricated pathogenesis. Thus, specifying essential mechanisms targets in silicosis progression then exploring anti-silicosis pharmacuticals desperately needed. In this work, multi-omics atlas was constructed depict pivotal abnormalities of develop targeted agents. By...
Rationale: Silicosis is a severe occupational lung disease. Current treatments for silicosis have highly limited availability (i.e., transplantation) or, do not effectively prolong patient survival time lavage). There thus an urgent clinical need effective drugs to retard the progression of silicosis. Methods: To systematically characterize molecular changes associated with and discover potential therapeutic targets, we conducted transcriptomics analysis human tissues acquired during...
Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide, but the molecular basis underlying its development remains unclear. An accumulating body evidence supports gasdermin D (GSDMD)-mediated pyroptosis as key component in various pulmonary diseases. However, there little experimental connecting silicosis GSDMD-driven pyroptosis. In this work, we investigated role GSDMD-mediated silicosis. Single-cell RNA sequencing healthy human murine lung tissues...
Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary inflammation, fibrosis and lung dysfunction. Currently, the pathophysiological process silicosis has not been well studied. Here, we defined progression as four stages unsupervised clustering analysis: normal stage, inflammatory progressive stage fibrotic stage. Specifically, in function was normal, no inflammation or detected tissue. Inflammatory showed a remarkable but mild In significant...
Previous research on vascular calcification has mainly focused the intima and media. However, we show here that may also occur in adventitia. The purpose of this work is to help elucidate pathogenic mechanisms underlying calcification. calcified lesions were examined by Von Kossa staining ApoE−/− mice which fed high fat diets (HFD) for 48 weeks human subjects aged 60 years older had died coronary heart disease, failure or acute renal failure. Explant cultured fibroblasts smooth muscle cells...
Abstract Multiterritorial atherosclerosis has dramatically increased annual risk of adverse cardiovascular events than atherosclerotic disease with single‐artery affected. Serum uric acid (SUA) is an important predictor stroke and atherosclerosis; however, which supported by few direct evidence based on cohort studies. A prospective study including 2644 North Chinese adults aged ≥40 years was performed in 2010‐2012 to investigate the association between SUA multiterritorial vascular...
Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, may not perfectly reflect nature human progression. A comprehensive profiling molecular changes in lungs urgently needed. Here, we conducted RNA sequencing (RNA-seq) on tissues 10 patients and 7 non-diseased donors. total 2,605 differentially expressed genes (DEGs) critical pathway were...
Silicosis is one of the most important occupational diseases worldwide, caused by inhalation silica particles or free crystalline silicon dioxide. As a disease with high mortality, it has no effective treatment and new therapeutic targets are urgently needed. Recent studies have identified FCER1A, encoding α-subunit immunoglobulin E (IgE) receptor FcεRI, as candidate gene involved in biological pathways leading to respiratory symptoms. FcεRI known be allergic asthma, but its role silicosis...
Inhalation of crystalline silica dust induces incurable lung damage, silicosis and pulmonary fibrosis. However, the mechanisms injury remain poorly understood, with limited therapeutic options aside from transplantation. Post-translational modifications can regulate function proteins play an important role in studying disease mechanisms. To investigate changes post-translational silicosis, combined quantitative proteome, acetylome, succinylome analyses were performed tissues silica-injured...
Predicting new drug–pathway interactions from heterogeneous biological data is important not only for the understanding of various drug response and molecular interaction processes, but also development novel drugs therapy human diseases. In this paper, three different learning methods including Bipartite Local Models method (BLM), Gaussian Interaction Profiles kernels (GIP) Graph-based Semi-supervised Learning (GBSSL) were used to predict interactions. To realize purpose, firstly...
Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate ATP in glycolysis plays a role regulating cell metabolism. It reported activity increased cancers. Phosphoribosyl amidotransferase (PPAT) be crucial regulator for lung cancer. However, its thyroid cancer remains largely unknown.Immunohistochemical analysis qRT-PCR were used detect expression PPAT samples. Both gain-of-function loss-of-function models constructed lines biological functions on...
Idiopathic pulmonary fibrosis (IPF) is an age-related disease. Failure of the proteostasis network with age, including insufficient autophagy, contributes to pathology IPF. Mechanisms underlying autophagy disruption in IPF are unclear and may involve regulation USP (ubiquitin-specific protease) by post-translational modifications. To expand our previous observation low USP13 expression IPF, this study evaluated role lung fibrosis. Here, we demonstrated that Usp13-deficient aged mice...
Bone metastases occur in 50-70% of patients with breast cancer (BC) and result high mortality. Platelet distribution width (PDW), a commonly used parameter activated platelets, has been associated poor prognosis BC. We aim to investigate the prognostic role PDW for bone metastasis BC patients.
Emergence of compound molecular data coupled to pathway information offers the possibility using machine learning methods for compound-pathway associations' inference. To provide insights into global relationship between compounds and their affected pathways, a improved Rotation Forest ensemble method called RGRF (Relief & GBSSL - Forest) was proposed predict potential associations. The main characteristic lies in Relief algorithm feature extraction regarding Graph-Based Semi-Supervised...
Progressive fibrosing interstitial lung diseases (PF-ILDs) result in high mortality and lack effective therapies. The pathogenesis of PF-ILDs involves macrophages driving inflammation irreversible fibrosis. Fc-γ receptors (FcγRs) regulate inflammation, but their roles remain unclear. We characterized the expression FcγRs found upregulated FcγRIIB human mouse lungs after exposure to silica. deficiency aggravated dysfunction, fibrosis silica-exposed mice. Using single-cell transcriptomics...
We compared the clinical effects and prognosis of patients receiving lymph node dissection after surgical removal thyroid tissues those not it removal. A total 80 diagnosed with differentiated carcinoma (DTC) by our hospital from March 2012 to 2014 were successively included in study. The cases divided into control group (n=36 cases) observation (n=44 cases), two groups underwent or subtotal resection thyroid. In group, preoperative high-frequency color ultrasonography, most suspicious was...
Abstract Background and Purpose Pneumoconiosis, especially silicosis, is a prevalent occupational disease with substantial global economic implications lacks definitive cure. Both pneumoconiosis idiopathic pulmonary fibrosis (IPF) are interstitial lung diseases, which share many common physiological characteristics. Because pirfenidone nintedanib approved to treat IPF, their potential efficacy as antifibrotic agents in advanced silicosis deserves further exploration. Thus, we aimed evaluate...
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive condition characterized by the impairment of alveolar epithelial cells. Despite continued research efforts, effective therapeutic medication still absent due to an incomplete understanding underlying etiology. It has been shown that rhythmic alterations are significant importance in pathophysiology IPF. However, comprehensive how metabolite level changes with circadian rhythms individuals IPF lacking. Here, we constructed...
Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of stomach, and their malignant potential has been demonstrated. In present study, we evaluated mucin phenotypes GHPs investigated relationships among clinical-pathological factors, proliferative activity p53 expression in GHPs.The CD10, MUC2, MUC5AC MUC6 patterns 238 were examined by immunohistochemical staining. The GHP divided into 4 subtypes: gastric phenotype (G-type), intestinal (I-type), mixed or gastrointestinal...