A5000009437- Occupational and environmental lung diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurological Disease Mechanisms and Treatments
- Vascular Anomalies and Treatments
- Genetic Associations and Epidemiology
- Medicinal Plants and Neuroprotection
- Ginger and Zingiberaceae research
- Renal function and acid-base balance
- Air Quality and Health Impacts
- Pleural and Pulmonary Diseases
- Cardiovascular Issues in Pregnancy
- Alzheimer's disease research and treatments
- Antimicrobial Peptides and Activities
- Gut microbiota and health
- Neuroscience of respiration and sleep
- Cardiac tumors and thrombi
- Asthma and respiratory diseases
- Saffron Plant Research Studies
- Cardiovascular Function and Risk Factors
- Traditional Chinese Medicine Analysis
- Occupational exposure and asthma
- Inhalation and Respiratory Drug Delivery
- Helicobacter pylori-related gastroenterology studies
First Hospital of Shanxi Medical University
2024-2025
Shanxi Medical University
2024-2025
State Key Laboratory of Respiratory Disease
2025
Nanjing University of Chinese Medicine
2011-2019
The bidirectional relationship between pulmonary hypertension (PH) and sleep disorders has attracted significant research attention. concept of the lung-brain axis further highlighted need for a holistic approach to managing these diseases. This study used two-sample Mendelian Randomization (MR) explore genetic-level causal relationships PH, disorders, structural brain changes. GWAS data PH were pooled from four cohorts; on disorder subtypes sourced FinnGen database; 15 changes obtained...
Coal worker's pneumoconiosis (CWP) is characterized by chronic inflammation and pulmonary fibrosis. The key factor contributing to the incurability of CWP unclear pathogenesis. This study explored characteristic changes in proteomics metabolomics early advanced patients through techniques. Proteomics identified proteins that change with progression CWP, significant enrichment TGF-β signaling pathway autoimmune disease pathways. Metabolomics revealed metabolic characteristics at different...
Objectives To investigate the mediating role of activation degree arginine-proline metabolism in association coal dust and decreased lung function. Methods Cumulative exposure (CDE) represented exposure, whereas hydroxyproline-to-arginine concentration ratio (Hyp/Arg) bronchoalveolar lavage fluid gauged activation. Pulmonary function indicators, including predicted value forced vital capacity (FVC%pred), expiratory volume 1 second/forced (FEV1/FVC%), actual to FEV1 (FEV1%pred), diffusing...
ABSTRACT Coal workers’ pneumoconiosis (CWP) is a severe occupational disease resulting from prolonged exposure to coal dust. However, its pathogenesis remains elusive, compounded by lack of early detection markers and effective treatments. Although the impact gut microbiota on lung diseases acknowledged, specific role in CWP unclear. This study aims explore changes microbiome metabolome CWP, while also assessing correlation between microbes alterations function. Fecal specimens 43 patients...
Abstract Background Fibrosing mediastinitis (FM) is a rare yet fatal condition, caused by different triggers and frequently culminating in the obstruction of pulmonary vasculature airways, often leading to hypertension right heart failure. Percutaneous transluminal venoplasty (PTPV) an emerging treatment for vein stenosis (PVS) FM. Our previous study showed as high 24% in-stent restenosis (ISR) However, predictors ISR are elusive. Objectives We sought identify patients with PVS extraluminal...
Jia-Wei-Kai-Xin-San (JWKXS) is a Chinese medicine formula applied for treating morbid forgetfulness in ancient China. Today, this frequently Alzheimer's disease and vascular dementia (VD) clinic. Here, we developed it as granules aimed to evaluate its anti-AD effect on amyloid protein 1-42 (A1-42) induced cognitive deficit mice reveal the possible molecular mechanisms. Firstly, daily intra-gastric administration of chemically standardized JWKXS seven days significantly ameliorated...
Abstract A fast, sensitive, and reliable ultra‐high performance liquid chromatography coupled with tandem mass spectrometry method has been developed validated for simultaneous quantification of geniposide, polygalaxanthone III, 3,6′‐disinapoyl sucrose, α‐asarone, β‐asarone, poricoic acid A, B, dehydrotumulosic acid, deoxyschizandrin, schizandrin kaempferide in plasma after oral administration extracts Jia‐Wei‐Kai‐Xin‐San normal vascular dementia rats. The was precise accurate within the...
Purpose: Smoking is a major risk factor for the group 3 PH. NT-proBNP biomarker stratification in This study aims to investigate effects of smoking status and index (SI) on PH evaluate value SI combined with early diagnosis prediction disease severity. Patients Methods: Four hundred patients at First Hospital Shanxi Medical University between January 2020 December 2021 were enrolled divided into two groups: mild (30 mmHg ≤ pulmonary artery systolic pressure (PASP)≤ 50 mmHg) non-mild (PASP >...
Abstract Background and Purpose Pneumoconiosis, especially silicosis, is a prevalent occupational disease with substantial global economic implications lacks definitive cure. Both pneumoconiosis idiopathic pulmonary fibrosis (IPF) are interstitial lung diseases, which share many common physiological characteristics. Because pirfenidone nintedanib approved to treat IPF, their potential efficacy as antifibrotic agents in advanced silicosis deserves further exploration. Thus, we aimed evaluate...
To investigate the stability and conversion rules of cantharidin cantharidic acid contained in Mylabris aqueous solution under different conditions. The contents conditions (pH, temperature light) were determined by HPLC-TQ-MS. results showed that content was gradually decreased with rising pH value, while on contrary, increased gradually; after values placed at 25, 40 ℃ 25 respectively for lighting 90 days, samples collected analysis. changed greatly first 10 mainly including decrease...
Summary Baihe Zhimu Tang (BZT) is a widely used traditional Chinese medicinal formula for the treatment of various diseases; however, its active components have remained unknown. In this study, high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS) methods were developed analysis metabolic BZT. The HPLC experiments reversed-phase Shim-Pack VP-ODS C18 column with temperature at 35°C and mobile phase system consisting aqueous formic acid (0.05%, υ/υ)...