A5000254862- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Aortic Disease and Treatment Approaches
- Circular RNAs in diseases
- Nutrition and Health in Aging
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Liver Disease and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Asthma and respiratory diseases
- Breast Cancer Treatment Studies
- Aortic aneurysm repair treatments
- Intensive Care Unit Cognitive Disorders
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Enhanced Recovery After Surgery
- Clinical Nutrition and Gastroenterology
- Cancer, Lipids, and Metabolism
Nanjing Drum Tower Hospital
2021-2025
Shandong University of Traditional Chinese Medicine
2025
Southern Illinois University Edwardsville
2025
Central South University
2006-2025
Renji Hospital
2025
Shanghai Jiao Tong University
2025
Third Xiangya Hospital
2025
Nanjing Medical University
2014-2024
Jiangsu Province Hospital
2014-2024
Shanxi Medical University
2009-2024
<p>We develop a mechanistic model that classifies individuals both in terms of epidemiological status (SIR) and vaccination attitude (Willing or Unwilling/Unable), with the goal discovering how disease spread is influenced by changing opinions about vaccination. Analysis identifies existence stability criteria for disease-free endemic equilibria. The analytical results, supported numerical simulations, show changes induced prevalence can destabilize equilibria, resulting limit cycles.</p>
Pyruvate kinase type M2 (PKM2) has been reported to be involved in aerobic glycolysis and cell growth various tumors. However, the expression pattern of PKM2 colorectal cancer (CRC) correlation between CRC remains unclear. The aim this study is investigate its possible role CRC. We found that was increased associated with later stage lymph metastasis Knockdown suppressed decreased lactate production colon RKO cells. repressed proliferation migration Inhibition xenograft tumor cells vivo....
Urothelial cancer associated 1 (UCA1) is an example of functional long noncoding RNAs involved in many biologic processes. However, little known about the association between UCA1 expression and metastasis epithelial ovarian (EOC). Findings this study confirmed that not only was aberrantly upregulated EOC tissues cells, but also correlated with status lymph node FIGO stage. Furthermore, univariate multivariate analyses showed a prognostic factor for overall survival patients. In vitro,...
Endometrial cancer (EC) is the fourth most common malignancy of female genital tract worldwide. MicroRNAs are important gene regulators with critical roles in diverse biological processes, including tumorigenesis. Several study’s show that miR-139-5p involved tumorigenesis and metastasis various cancers. However, its expression potential biologic role endometrial remain to be determined. This study aimed investigate analyze function underlying molecular mechanism cancer. Expression was...
Circulating tumor cells (CTCs) have been described as a population of that may seed metastasis, which is reliable target for the prevention metastases in lung cancer patients at early stage. The culturing CTCs vitro can be used to study mechanism metastasis and screen antimetastasis drugs. This aims establish CTC cell line explore potential its metastasis. A mixture EpCAM- EGFR-coated immunomagnetic microbeads microfluidic Herringbone-Chip was capture CTCs. CTCs, 95-D A549 evaluated by...
Chronic inflammation is a well-known etiological factor for colorectal cancer (CRC) and cells are known to preferentially metabolize glucose through aerobic glycolysis. However, the connection between chronic glycolysis in development of CRC largely unexplored. The present study investigated whether interleukin-6 (IL-6), pro-inflammatory cytokine, promotes by regulating underlying molecular mechanisms. In colitis-associated mouse, anti-IL-6 receptor antibody treatment reduced incidence...
Little is known about the changes in allergen sensitization China secondary to environmental variations over past decade. We aimed at investigating among asthma and/or rhinitis patients between 2008 and 2018.This study analyzed cross-sectional data from national surveys conducted 2018. After finishing questionnaire, participants underwent serum specific IgE measurements. A total of 2322 2798 were enrolled 2018, respectively. The significance differences rates four regions assessed....
Background: Type A aortic dissection (TAAD) remains a significant challenge in cardiac surgery, presenting high risks of adverse outcomes such as permanent neurological dysfunction and mortality despite advances medical technology surgical techniques. This study investigates the use quantitative electroencephalography (QEEG) to monitor predict during perioperative period TAAD patients. Methods: prospective observational was conducted at hospital, involving patients undergoing surgery from...
Purpose Using deep learning model to observe the blinking characteristics and evaluate changes their correlation with tear film in children long-term use of orthokeratology (ortho-K). Methods 31 (58 eyes) who had used ortho-K for more than 1 year age gender-matched controls were selected follow-up our ophthalmology clinic from 2021/09 2023/10 this retrospective case-control study. Both groups underwent comprehensive ophthalmological examinations, including Ocular Surface Disease Index (OSDI)...
Background Gastrointestinal bleeding is a serious adverse event of coronary artery bypass grafting and lacks tailored risk assessment tools for personalized prevention. Objective This study aims to develop validate predictive models assess the gastrointestinal after (GIBCG) guide Methods Participants were recruited from 4 medical centers, including prospective cohort Medical Information Mart Intensive Care IV (MIMIC-IV) database. From an initial 18,938 patients, 16,440 included in final...
Précis: 240° and 360° goniotomy (GT) demonstrated similar efficacy in intraocular pressure reduction, both outperforming 120°GT juvenile open-angle glaucoma (JOAG) patients at postoperative 6 months follow-up. Purpose: To compare the surgical safety of 120-, 240-, 360-degree for with (JOAG). Patients Methods: This multicenter retrospective study included 102 eyes JOAG patients, who underwent GT a follow up least months. were categorized into three groups: (1) 120°GT, (2) 240°GT, (3) 360°GT....
Abstract The density of tumor-infiltrating lymphocytes (TILs) serves as a valuable indicator for predicting anti-tumor responses, but its broad impact across various types cancers remains underexplored. We introduce TILScout, pan-cancer deep-learning approach to compute patch-level TIL scores from whole slide images (WSIs). TILScout achieved accuracies 0.9787 and 0.9628, AUCs 0.9988 0.9934 in classifying WSI patches into three categories—TIL-positive, TIL-negative, other/necrotic—on...
Liver ischemia and reperfusion (I/R) injury is characterized by defective liver autophagy accompanied alterations to the endogenous defense system. Dihydromyricetin (DHM) a natural flavonoid that demonstrates wide range of physiological functions, has been implicated as regulator autophagy. This study investigates protective effects DHM pretreatment on caused ischemia/reperfusion elucidates potential mechanism DHM-mediated protection. Mice were subjected 60 minutes followed 5 hours...
Abstract Cervical cancer is the fourth most common malignancy in women worldwide and cervical squamous cell carcinoma (CESC) histological type of cancer. The dysregulation genes plays a significant role In present study, we screened out differentially expressed (DEGs) CESC GSE63514 data set from Gene Expression Omnibus database. An integrated bioinformatics analysis was used to select hub genes, as well investigate their related prognostic signature, functional annotation, methylation...