A5100718942- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Molecular Sensors and Ion Detection
- Synthesis and Catalytic Reactions
- Axial and Atropisomeric Chirality Synthesis
- Catalytic Alkyne Reactions
- Click Chemistry and Applications
- Genomics, phytochemicals, and oxidative stress
- Molecular spectroscopy and chirality
- Biological Activity of Diterpenoids and Biflavonoids
- Crystal structures of chemical compounds
- Crystallography and molecular interactions
- Synthetic Organic Chemistry Methods
- Biopolymer Synthesis and Applications
- Analytical chemistry methods development
- Autophagy in Disease and Therapy
- Fungal Plant Pathogen Control
- Adsorption and biosorption for pollutant removal
- Bioactive natural compounds
- Phytochemical compounds biological activities
Army Medical University
2014-2024
Jiangsu Normal University
2010-2024
Army Medical College
2024
Second Hospital of Shanxi Medical University
2023
Shanxi Medical University
2023
Hangzhou Normal University
2021-2023
Henan Normal University
2022-2023
Shanghai Jiao Tong University
2008-2023
Beijing Technology and Business University
2023
Shenyang Agricultural University
2022
A newly developed Ar-BINMOL-Phos-controlled Rh/Cu-catalyzed (4+2) annulation of silacylcobutanes with arylpropiolate-type internal alkynes gave silicon-stereogenic 1-sila-2-cyclohexene derivatives good ee and excellent chemoselectivity.
Abstract Systemic inflammatory response syndrome (SIRS) is an overwhelming whole body inflammation caused by infectious diseases or sterile insults. Neutrophils are the dominant participants during inflammation, and their survival death determine initiation as well resolution of SIRS. Apoptosis autophagy two fundamental cellular processes that modulating cell fate, but correlation regulators in neutrophils under SIRS condition have not been elucidated. In this study, we demonstrated high...
Abstract Although asymmetric C−H functionalization has been available for the synthesis of structurally diverse molecules, catalytic dynamic kinetic resolution (DKR) approaches to change racemic stereogenic axes remain synthetic challenges in this field. Here, a concise palladium‐catalyzed DKR was combined with involving olefination and alkynylation highly efficient non‐biaryl‐atropisomer‐type (NBA) axially chiral oragnosilanes. The chemistry proceeded through two different distinct DKR:...
Abstract A highly chemoselective conjugate addition of alcohols in the presence amines is described. The cooperative nature catalyst enabled activation over amines, allowing to soft Lewis basic α,β‐unsaturated nitriles. Divergent transformation nitrile functionality highlights utility present catalysis.
A base-promoted cascade reaction for the regiospecific synthesis of substituted 3-hydroxyisoindolinones under transition-metal-free conditions is developed. The base-mediated C-C bond coupling and N-α-sp3C-H hydroxylation are involved in this procedure, which features high regioselectivity, efficiency, environmental friendliness. Various 3-hydroxyisoindolinones, including some bioactive molecules, were provided up to 93% yield 28 examples.
Tobacco smoke (TS) has been shown to cause gastric cancer. Epithelial–mesenchymal transition (EMT) is a crucial pathophysiological process in cancer development. Mitogen-activated protein kinase (MAPK) pathways play central roles tumorigenesis including EMT process. Curcumin promising chemopreventive agent for several types of cancers. In the present study, we investigated effects TS on MAPK pathway activation and alterations stomach mice, preventive effect curcumin was further examined....
A chemoselective functional group installation through catalytic hydroxy selective conjugate addition of amino alcohols to a variety functionalized α,β-unsaturated sulfonyl derivatives was developed. Azide for click chemistry and facile fluorescent labeling onto the less reactive demonstrated synthetic utility present catalysis. Moreover, chemo- regioselective reaction an unprotected diol achieved first time.
Bladder cancer (BC) is universally acknowledged as a significant public health issue, worldwide. Numerous studies have demonstrated that cigarette smoke the primary risk factor for BC. However, mechanism of smoke‑induced BC has not been fully elucidated. Sustained epithelial cell hyperplasia identified preneoplastic lesion during formation The aim present study was to investigate whether exposure extract (CSE) induced proliferation in normal human urothelial SV‑HUC‑1 cells. Furthermore, role...
Phenoxy acetophenones were usually employed as β-O-4′ lignin models for chemical conversion. Herein, an iridium-catalyzed dehydrogenative annulation between 2-aminobenzylalcohols and phenoxy was demonstrated to prepare valuable 3-oxo quinoline derivatives, which are hard using previous methods. This operationally simple reaction tolerated a wide scope of substrates enabled successful gram-scale preparation.
A base-catalysed [3 + 2] cycloaddition reaction using propargylamines as allenyl anion equivalents for the regiospecific synthesis of substituted furans under metal-free conditions is developed.
N-(o-methoxybenzamido)thioureas (2 X/2 Y) are found to show an enhanced anion binding affinity with constants over 10(7) mol(-1) L orders of magnitude for AcO(-) and a redshifted absorption the complexes in acetonitrile (MeCN) relative those N-benzamidothioureas (1) that bear no o-OMe N-benzamide moiety, despite electron-donating character o-OMe. Absorption anion-2 Y complex was shown be same charge-transfer nature as anion-1 complex, but its dependence on substituent X is interestingly...
Autophagy is increasingly being recognized as a critical determinant of vascular smooth muscle cell (VSMC) biology. Previously, we have demonstrated that c-Ski inhibits VSMC proliferation stimulated by transforming growth factor β (TGF-β), but it not clear whether has the similar protective role against other injury factors and regulation autophagy involved in its effects on VSMC. Accordingly, this study, rat aortic A10 VSMCs were treated with 40 µg/ml oxidized low-density lipoprotein...
Abstract A fluorine‐containing tetrasubstituted stereogenic center is a highly valued structural feature in medicinal chemistry. Herein, we describe the direct coupling of racemic α‐fluoronitriles and aldehydes promoted by chiral Cu I /Barton's base catalytic system, delivering α‐tetrasubstituted α‐fluoro‐β‐hydroxynitriles with satisfactory stereoselection. The stereochemical course was positively biased combined use asymmetrical achiral thiourea as supplementary ligand for , which...
A highly chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester using a soft Lewis acid/hard Brønsted base cooperative catalyst was developed. This catalysis achieved hydroxy group over an group. Moreover, metal alkoxide generation enabled hard transesterification. Various alcohols, including unprecedented cyclic β-amino alcohol, were applicable the present catalysis.
α-Trichloromethylation of tertiary amines with trimethyl(trichloromethyl)silane by oxidative coupling, using DDQ as an oxidant, has been realized. The reaction is instantaneous, scalable, and tolerates a broad range functional groups heteroarenes. trichloromethylated products can be easily converted into β,β-dichloroamines, enamines, α-amino acid esters under operationally simple conditions. This methodology provides efficient alternative to the poisonous cyanation reactions for synthesis...