This feature article systematically summarizes the development of fluorescent probes for selective detection chemical species inside mitochondria.

A new ratiometric fluorescence probe E1 based on an excited-state intramolecular proton transfer (ESIPT) mechanism for detection of hydrogen sulfide (H2S) is reported. responds to H2S quickly and showed a 30-fold enhancement in 2 minutes. Moreover, can detect quantitatively with limit as low 0.12 μM aqueous solution. Its potential biological applications was confirmed by employing it imaging living cells.

Two-dimensional vibrational spectroscopy is applied to investigate the dilution process of 1-ethyl-3-methyl-imidazolium tetrafluoroborate ([Emim][BF4]) in water. With increasing water content ionic liquid (IL)/water mixtures, C-H stretching vibration imidazolium cation showed systematic blue-shifts, which reflect weakening cohesion between and anion ILs. The two-dimensional IR results reveal that ILs sense quite different environments during whole process. First, three-dimensional network...

This work focuses on developing diketopyrrolopyrrole (DPP)‐based small molecular nonfullerene acceptors for bulk heterojunction (BHJ) organic solar cells. The materials, SF‐DPP s, have an X‐shaped geometry arising from four DPP units attached to a spirobifluorene (SF) center. spiro‐dimer of DPP‐fluorene‐DPP is highly twisted, which suppresses strong intermolecular aggregation. Branched 2‐ethylhexyl (EH), linear n ‐octyl (C8), and ‐dodecyl (C12) alkyl sides are chosen as substituents...

Arylsilanes are valuable organosilicon compounds and attract significant research interest due to their promising applications in organic synthesis. The development of aromatic C–Si cross-coupling reactions represents a major challenge both chemistry A number investigations focused on developing transition-metal-catalyzed Si–C coupling the associated high atom economy superior functional group compatibility. This review describes recent advances selective silylations aryl C–H C–X (X =...

Abstract A novel and unusual palladium‐catalyzed [4+2] annulation of cyclopropenes with benzosilacyclobutanes is reported. This reaction occurred through chemoselective Si−C(sp 2 ) bond activation in synergy ring expansion/insertion to form new C(sp )−C(sp 3 bonds. An array previously elusive bicyclic skeleton high strain, silabicyclo[4.1.0]heptanes, were formed good yields excellent diastereoselectivity under mild conditions. asymmetric version the a chiral phosphoramidite ligand furnished...

Abstract The synthesis of a series aromatic amide‐derived non‐biaryl atropisomers with phosphine group and multiple stereogenic centers is reported. novel ligands exhibit high diastereo‐ enantioselectivities (up to >99:1 d.r., 95–99 % ee ) as well yields in the silver‐catalyzed asymmetric [3+2] cycloaddition aldiminoesters nitroalkenes, which provides highly enantioselective strategy for optically pure nitro‐substituted pyrrolidines. In addition, experimental results regard carbon center...

Tetherball: A heterogeneous, mesoporous silica-tethered iridium catalyst (Ir-PN/SBA-15) containing a bidentate iminophosphine ligand is synthesized for the hydrogenation of CO2 to formic acid in aqueous solution. This new recyclable exhibits high activities production under mild conditions [60 °C, 4.0 MPa total pressure (H2/CO2=1:1)]. As service our authors and readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized...

This feature article comprehensively summarizes the development of small-molecule fluorescent probes for specific detection and imaging chemical species inside lysosomes.

The development of highly effective chiral ligands is a key topic in enhancing the catalytic activity and selectivity metal-catalyzed asymmetric synthesis. Traditionally, difficulty ligand synthesis, insufficient accuracy controlling stereoselectivity, poor universality systems often become obstacles this field. Using concept nonequivalent coordination to metal, our group has designed synthesized series new catalysts access various carbon/silicon and/or multiple stereogenic centers...

Catalytic hydrosilylation of alkenes ranks as one the most important academic and industrial synthetic reactions in homogeneous catalysis organosilicon chemistry. In this work, a highly enantioselective Rh-catalyzed desymmetric reaction 1,1-disubstituted cyclopropenes with promotion chiral DTBM-SEGPHOS is described. It allows for straightforward access to potentially valuable compounds bearing carbon quaternary stereocenter high yields good diastereo- enantioselectivities (up >99:1 d.r. >99%...

Abstract Hydrosilylation of unsaturated carbon-carbon bonds with hydrosilanes is a very important process to access organosilicon compounds and ranks as one the most fundamental reactions in organic chemistry. However, catalytic asymmetric hydrosilylation activated alkenes internal has proven elusive, due competing reduction double bond or isomerization processes. Herein, we report highly enantioselective Si-C coupling by carbonyl-activated using palladium catalyst chiral TADDOL-derived...

Abstract Strategies on the construction of enantiomerically pure silicon‐stereogenic silanes generally relies desymmetrization prochiral and symmetric substrates. However, dynamic kinetic asymmetric transformations organosilicon compounds have remained underdeveloped unforeseen owing to a lack an effective method for deracemization static silicon stereocenters. Here we report first Rh‐catalyzed intramolecular hydrosilylation (DyKAH) with “silicon‐centered” racemic hydrosilanes that enables...

Abstract A Cu‐catalyzed asymmetric synthesis of silicon‐stereogenic benzoxasiloles has been realized via intramolecular Si−O coupling [2‐(hydroxymethyl)phenyl]silanes. Cu(I)/difluorphos is found to be an efficient catalytic system for enantioselective Si−C bond cleavage and formation. In addition, kinetic resolution racemic substituted [2‐(hydroxymethyl)phenyl]silanes using Cu(I)/ PyrOx (pyridine‐oxazoline ligands) as the developed afford carbon‐ benzoxasiloles. Ring‐opening reactions chiral...

A copper catalyst system derived from TaoPhos and CuF2 was used successfully for catalytic asymmetric Huisgen [3+2] cycloaddition of azides alkynes to give optically pure products containing succinimide- triazole-substituted quaternary carbon stereogenic centers. The desired were obtained in good yields (60-80 %) 85:15 >99:1 enantiomeric ratio (e.r.) this click reaction.

An enantioselective Pd-catalyzed silicon–carbon bond-forming silylation reaction of aryl iodides with hydrosilanes for the synthesis silicon-stereogenic silanes has been developed good enantioselectivity under mild conditions.

A naphthalimide-based fluorescent probe for selectively detecting His in aqueous solution, living cells, and<italic>C. elegans</italic>has been developed.

Abstract A palladium‐catalyzed enantioselective intramolecular σ‐bond cross‐exchange between C−I and C−C bonds is realized, providing chiral indanones bearing an alkyl iodide group all‐carbon quaternary stereocenter. Pd/TADDOL‐derived phosphoramidite found to be efficient catalytic system for both bond cleavage reductive elimination. In addition aryl iodides, bromides can also used this transformation in the presence of KI. Density‐functional theory (DFT) calculation studies support...

Chirality widely exists in a diverse array of biologically active molecules and life forms, the catalytic constructions chiral have triggered heightened interest fields chemistry materials pharmaceutical sciences. However, synthesis silicon-stereogenic organosilicon compounds is generally recognized as much more difficult task than that carbon-stereogenic centers because no abundant organosilicon-based sources nature. Herein, we reported highly enantioselective rhodium-catalyzed...

A palladium-catalyzed ketoxime-chelation-assisted C–H olefination was developed to afford axially chiral vinyl arenes with excellent enantioselectivities.

The Sonogashira-type cross-coupling reaction is one of the most significant alkynylation transformations in organic chemistry. However, highly enantioselective via rather limited, mainly due to difficulties matching stereoselective induction chiral ligands with combinational behavior Pd/Cu-based bimetallic catalysts. We herein report novel palladium/copper-catalyzed alkyl cyclobutanones terminal alkynes tandem C-C bond activation/Sonogashira-type cross coupling reaction, which a...