A5102024220- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Airway Management and Intubation Techniques
- Cardiovascular and Diving-Related Complications
- Extracellular vesicles in disease
- COVID-19 diagnosis using AI
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Adipose Tissue and Metabolism
- Macrophage Migration Inhibitory Factor
- Hydrogen's biological and therapeutic effects
- Fungal Infections and Studies
- Asthma and respiratory diseases
- Advanced Radiotherapy Techniques
- Pneumothorax, Barotrauma, Emphysema
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
Guangdong Academy of Medical Sciences
2013-2025
Guangdong Provincial People's Hospital
2019-2025
Southern Medical University
2016-2025
Beijing Normal University
2024
Guangdong General Hospital
2009-2018
Peking University First Hospital
2018
Peking University
2018
University of Science and Technology of China
2016
North China Electric Power University
2009
Abstract Background Computed tomography (CT) is essential for pulmonary nodule detection in diagnosing lung cancer. As deep learning algorithms have recently been regarded as a promising technique medical fields, we attempt to integrate well-trained algorithm detect and classify nodules derived from clinical CT images. Materials Methods Open-source data sets multicenter used this study. A three-dimensional convolutional neural network (CNN) was designed them into malignant or benign diseases...
Chronic obstructive pulmonary disease (COPD) has become a leading cause of morbidity and mortality in China, with tobacco smoke, air pollution, occupational biohazards being the major risk factors.
Obstructive sleep apnea (OSA) is much more prevalent in older people than middle-aged or young populations, and has been associated with cardiovascular disease. Continuous positive airway pressure (CPAP) the first-line therapy for OSA, but its long-term clinical benefit elderly unclear. Here, we carried out a prospective cohort study to explore survival rate incidence of events patients moderate severe OSA who did not receive CPAP treatment. The included 130 (104 male, 26 female; mean age:...
Obstructive sleep apnea (OSA) is recognized to increase the risk of dyslipidemia; however, specific traits in OSA that influence dyslipidemia are poorly understood. This study sought determine which independently associated with and serum lipid profiles patients OSA. In this cohort study, 5239 participants were included from Sleep Heart Health Study. Further, was diagnosed via polysomnography an AHI ≥ 5 events/h. assessed using polysomnographic data questionnaires. Then, logistic regression...
The incidence of severe Chlamydia psittaci ( C. ) pneumonia and coinfections is increasing. Early detection this condition needed to prevent negative outcomes, along with detailed descriptions its associated clinical characteristics. Our study contributes by undertaking etiological analysis patients C . based on metagenomic next-generation sequencing (mNGS). A retrospective 30 was undertaken confirmed mNGS or polymerase chain reaction (PCR). Clinical manifestations the non-severe groups were...
Abstract Purpose Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), compromises immune surveillance through the upregulation programmed cell death-1 ligand (PD-L1). Tumor-released extracellular vesicles (EVs) have been reported to modulate immunosuppressive activities. We investigated whether or not EVs derived from intermittent hypoxic lung cancer cells can alter expression PD-L1 in macrophages. Methods The + monocytes 40 patients with newly diagnosed non-small-cell...
Most patients with comorbid sleep apnea (OSA), cardiovascular (CV) disease, and/or cerebrovascular (CeV) disease simultaneously take medications. Whether OSA and continuous positive airway pressure (CPAP) interact CV/CeV medications remains unknown. This study aimed to determine the interaction among OSA, CPAP, medications; effects of on major adverse cardiac events, survival in CV/CeV.
COVID-19 has become a major global threat. The present study aimed to develop nomogram model predict the survival of patients based on their clinical and laboratory data at admission.
Skeletal muscle dysfunction (SMD) is one of the most prominent extrapulmonary effects chronic obstructive pulmonary disease (COPD). Myostatin negatively regulates growth skeletal muscle. We confirmed that myostatin expression significantly increased in quadriceps femoris tissue rats with COPD and involved development SMD COPD, but mechanism by which this occurs has yet to be uncovered. Dynamin-related protein 1 (Drp-1) been shown promote apoptosis affect cellular energy metabolism mediating...
Because of the high incidence and poor prognoses lung adenocarcinoma (LUAD), it is essential to identify cost-effective treatment options accurate reliable prognostic biomarkers. CDCA4 upregulation has been identified in many cancers. However, importance its role LUAD remain unknown.CDCA4 expression was assessed through IHC, Western blotting (WB) RT-PCR. The Cancer Genome Atlas (TCGA) provided data from 513 patients study relevance LUAD. This used gene set enrichment analyses (GSEA),...
Introduction: Intermittent hypoxia (IH), an important feature of obstructive sleep apnea, enhances the function lung cancer cell-derived extracellular vesicles (EVs) to exacerbate immunosuppressive properties macrophages. Herein, we investigated effects EVs obtained from adenocarcinoma cells cultured under IH on macrophage polarization. Methods: The M1-type and M2-type tumor-associated macrophages (TAMs) in tissues cases with (n = 10) or without 12) OSA were assessed by immunohistochemical...
Echinoderm microtubule associated protein like 4 gene (EML4)–ALK receptor tyrosine kinase (ALK) and ROS1 rearrangements have been demonstrated to be driver genes in NSCLCs that can benefit from crizotinib. ALK rearrangement occurs approximately 5% of all lung adenocarcinomas 1.3% squamous cell cancer (SqCC), whereas accounts for 1% 3% rarely, has reported SqCC.1,2
Dieulafoy's disease of the bronchus is an arterial abnormality characterized by enlarged mucosal branches that are susceptible to lethal bleeding. To date, this rarely reported in literature. We recently encountered three patients from February 2010 March 2017, each with such a vascular anomaly massive hemoptysis. This paper describes clinical characteristics and treatments for disease. report cases recurrent Bronchoscopic examination was performed on two patients, one non-pulsating polypoid...
To identify protein biomarkers capable of early prediction regarding the distinguishing malignant pleural effusion (MPE) from benign (BPE) in patients with lung disease. A four-dimensional data independent acquisition (4D-DIA) proteomic was performed to determine differentially expressed proteins samples 20 adenocarcinoma MPE and 30 BPE. The significantly differential were selected for Gene Ontology (GO) enrichment Kyoto Encyclopaedia Genes Genomes (KEGG) pathway analysis. Protein high...
Abstract Background In allergic asthma, Th2 lymphocytes are believed to play important roles in orchestrating airway eosinophilia and inflammation. Resetting the Th1/Th2 imbalance may have a therapeutic role asthma. The mycobacterium tuberculosis 30-kilodalton major secretory protein (antigen 85B, Ag85B) can protect animals from M. infection by inducing Th1-dominant response. Methods this study, Ag85B gene was cloned into pMG plasmids yield pMG-Ag85B plasmid. expression of murine bronchial...
Primary pulmonary non-Hodgkin's lymphoma (PP-NHL) is a rare entity with non-specific symptoms and radiographic findings, as well difficult preoperative diagnosis. A limited number of studies have described PP-NHL in Chinese patients. The goal the present study was to improve early diagnosis by examining prognostic factors patients PP-NHL. Therefore, total 29 were included between January 2001 June 2017, including 14 aggressive-type 15 indolent-type lymphomas (10 male, 19 female; median age,...
Abstract Background Small peripheral pulmonary nodules, which are usually deep-seated with no visual markers on the pleural surface, often difficult to locate during surgery. At present, CT-guided percutaneous techniques used but this method has many limitations. Thus, we aimed evaluate accuracy and feasibility of electromagnetic navigational bronchoscopy (ENB) dye small nodules before video-associated thoracic surgery (VATS). Methods The ENB localisation procedure was performed under...
The adverse reaction of Black Hairy Tongue (BHT) caused by linezolid is rare. We reports a case linezolid-induced BHT, and reviews relevant literatures at home abroad. It aims to provide safe reasonable basis for clinical medication use. A 14-year-old adolescent with pneumonia methicillin-resistant Staphylococcus aureus (MRSA) developed rash pruritus due Vancomycin. Instead, the patient was given 600mg q12h in injection during hospitalization tablet after discharge. On 14th day second oral...
The REACH study is the first multicenter randomized controlled trial conducted in China assessing safety and effectiveness of endobronchial valve treatment for severe emphysema patients with complete fissures. objectives were target lobe volume reduction (TLVR) significant improvement lung function. 101 subjects, 66 35 control, enrolled at 12 sites. Target selection, based on visual HRCT identified an upper 55% a lower 45% patients. Treatment consisted occlusion utilizing Spiration Valve...
The Water Cherenkov Detector Array (WCDA) is one of the major components Large High Altitude Air Shower Observatory (LHAASO). In WCDA, 3600 Photomultiplier Tubes (PMTs) and Front End Electronics (FEEs) are scattered over a 90000 m2 area, while high precision time measurements (0.5 ns RMS) required in readout electronics. To meet this requirement, clock has to be distributed FEEs with precision. Due ``triggerless'' architecture, speed data transfer based on TCP/IP protocol. simplify...