A5082268791- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Breast Lesions and Carcinomas
- Endometrial and Cervical Cancer Treatments
- Head and Neck Cancer Studies
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastric Cancer Management and Outcomes
- Ovarian cancer diagnosis and treatment
- HER2/EGFR in Cancer Research
- Pleural and Pulmonary Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Risks and Factors
- Photodynamic Therapy Research Studies
- Metastasis and carcinoma case studies
National Yang Ming Chiao Tung University
2025
Shanghai Chest Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Northwest A&F University
2021-2024
Shanghai Children's Medical Center
2024
Nanjing Medical University
2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Sun Yat-sen University
2013-2023
Introduction: To assess the role of 21-gene recurrence score (RS) assay on decision-making postoperative radiotherapy (RT) following breast-conserving surgery (BCS) in elderly women with early-stage breast cancer. Methods: The RS for (≥65 years) stage T1–2N0M0 estrogen receptor-positive cancer who underwent BCS from 2004 to 2015 was obtained Surveillance, Epidemiology, and End Results program. We estimated association adjuvant RT related cancer-specific survival (BCSS) using propensity...
The aim is to diagnose COVID-19 earlier and improve its treatment by applying medical technology, the "COVID-19 Intelligent Diagnosis Treatment Assistant Program (nCapp)" based on Internet of Things. Terminal eight functions can be implemented in real-time online communication with "cloud" through page selection key. According existing data, questionnaires, check results, diagnosis automatically generated as confirmed, suspected, or suspicious 2019 novel coronavirus (2019-nCoV) infection. It...
Rationale: Ferroptosis, a newly identified form of regulated cell death, can be induced following the inhibition cystine-glutamate antiporter system XC- because impaired uptake cystine. However, outcome accumulation endogenous glutamate in lung adenocarcinoma (LUAD) has not yet been determined. Yes-associated protein (YAP) is sustained by hexosamine biosynthesis pathway (HBP)-dependent O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation), and glutamine-fructose-6-phosphate transaminase...
The prognostic significance of preoperative carcinoembryonic antigen (CEA) and cancer 15-3 (CA15-3) levels in breast is controversial. This study evaluated the value serum CEA CA15-3 Chinese patients. A total 470 patients with had concentrations measured. relationships between concentration clinicopathological factors outcomes were determined. increased 34 (7.2%) 58 (12.3%) patients, respectively. Elevations CA-15-3 correlated primary tumor size axillary lymph node status. lower...
Abstract Lessons Learned The findings of this prospective, single-arm, phase II study showed that neoadjuvant erlotinib was well tolerated and might improve the radical resection rate in patients with stage IIIA-N2 epidermal growth factor receptor mutation-positive non-small cell lung cancer (NSCLC). Erlotinib shows promise as a therapy option patient population. Next-generation sequencing may be useful for predicting outcomes preoperative tyrosine kinase inhibitors (TKIs) NSCLC. Large-scale...
Background Cryoablation is a minimally invasive option for patients with medically inoperable non-small cell lung cancer (NSCLC) and can trigger abscopal immune-regulatory effects. However, it remains unclear how cryoablation affects the host-level immune response in NSCLC. In this study, we investigated local systemic immunological effects of potential combining programmed death protein 1 (PD-1) blockade to boost immunotherapy efficacy Methods We first induced by early-stage Subsequently,...
Artificially aligned or positioned functional materials are essential building blocks for modern devices and nanoelectronics. Since the emergence of 2D materials, vertical stacking/integration exotic has garnered increasing attention. However, controlling homostructures, e.g. identical conjoined with varying crystalline orientations, magnetism, strain states, along lateral direction remains challenging. Leveraging on freestanding thin film growth techniques, concept twisted homostructures...
Introduction: Distant metastasis remains the major cause of treatment failure in esophageal cancer, though there have been few large-scale studies patterns distant different histological types. We investigated adenocarcinoma (AC) and squamous cell carcinoma (SCC) using a population-based approach. Methods: Patients with de novo stage IV cancer at diagnosis were identified Surveillance, Epidemiology, End Results database. Multivariable logistic regression was performed to identify potential...
Although some circRNAs have been found to regulate the progression of malignancies, their functions and coupled molecular mechanisms are still unclear. In our study, we sought assess underlying in breast cancer therefore explored differentially expressed co-expression networks, followed by vitro experiments.High-throughput RNA sequencing was performed obtain an unbiased profile circRNA expression. CircRNA-miRNA-mRNA networks were predicted, sequence analyses carried out. The MTT, transwell...
Anlotinib has been demonstrated in clinical trials to be effective prolonging the progression-free survival (PFS) and overall (OS) of refractory advanced nonsmall cell lung cancer (NSCLC) patients. However, underlying molecular mechanisms predictive biomarkers anlotinib are still unclear.A retrospective analysis administered 294 NSCLC patients was performed screen for anlotinib-responsive Transcriptome functional assays were understand antitumour anlotinib. Changes serum CCL2 levels analysed...
To investigate the effect of distant metastases sites on survival in patients with de novo stage-IV breast cancer. From 2010 to 2013, a diagnosis cancer were identified using Surveillance, Epidemiology, and End Results database. Univariate multivariate Cox regression analyses performed analyze cancer-specific overall survival. A total 7575 identified. The most common metastatic bone, followed by lung, liver, brain. Patients hormone receptor+/human epidermal growth factor receptor 2- 2+...
The aim of this study was to investigate the survival patients with signet ring cell carcinoma (SRCC) based on primary tumor location. Patient data were obtained from Surveillance, Epidemiology, and End Results database (1988-2012) ≥200 cases per Cox regression analysis used prognostic factors cause-specific (CSS). We identified 24,171 patients. Of patients, 63.4% had gastric SRCC, followed by colon (18.2%), esophageal (5.0%), rectal (3.5%), lung (3.1%), pancreatic (1.8%), breast (1.5%),...
The study aimed to search and identify genes that were differentially expressed in breast cancer, their roles cancer growth progression.The Gene Expression Omnibus (Oncomine) Cancer Genome Atlas databases (https://cancergenome.nih.gov/) screened for closely related a poor prognosis. expressions verified by quantitative real-time polymerase chain reaction, knocked down lentivirus-based system. Cell motility evaluated vivo nude mice used confirm the vitro of genes. Markers...
Automated airway segmentation is a prerequisite for pre-operative diagnosis and intra-operative navigation pulmonary intervention. Due to the small size scattered spatial distribution of peripheral bronchi, this hampered by severe class imbalance between foreground background regions, which makes it challenging CNN-based methods parse distal airways. In paper, we demonstrate that problem arisen gradient erosion dilation neighborhood voxels. During back-propagation, if ratio while local,...
Lung cancer is the leading cause of cancer-related deaths worldwide and in China. Screening for lung by low dose computed tomography (LDCT) can reduce mortality but has resulted a dramatic rise incidence indeterminate pulmonary nodules, which presents major diagnostic challenge clinicians regarding their underlying pathology lead to overdiagnosis. To address significant gap evaluating we conducted prospective study develop prediction model individuals at intermediate high risk developing...
Abstract Base editors (BEs) are a recent generation of genome editing tools that couple cytidine or adenosine deaminase activity to catalytically impaired Cas9 moiety (nCas9) enable specific base conversions at the targeted genomic loci. Given their strong application potential, BEs under active developments toward greater levels efficiency and safety. Here, previously overlooked nCas9‐centric strategy is explored for enhancement BE. Based on cytosine BE (CBE), 20 point mutations associated...
We have recently developed a flexible catheter electrode used for bronchoscopic radiofrequency ablation (RFA). Two patients with nonsurgical stage IA peripheral lung cancer and 1 metastasis underwent treatment RFA utilizing navigation bronchoscopy. Chest computed tomography (CT) positron emission tomography/CT (PET/CT) were performed before after to assess the response of patients. One patient's tumor had no prior PET uptake therefore follow-up was obtained. The first third patient obtained...